Results 101 to 110 of about 1,878,278 (369)

Effectiveness of Seeking Safety for Co-Occurring Posttraumatic Stress Disorder and Substance Use [PDF]

, 2016
The authors evaluated the Seeking Safety program\u27s effectiveness for treating posttraumatic stress disorder (PTSD) and substance use symptoms across 12 between‐groups studies (N = 1,997 participants).
Callender, Karisse A., Henesy, Rachel, Lenz, A. Stephen   +2 more
core   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Predicting Individual Substance Abuse Vulnerability using Machine Learning Techniques [PDF]

arXiv, 2020
Substance abuse is the unrestrained and detrimental use of psychoactive chemical substances, unauthorized drugs, and alcohol. Continuous use of these substances can ultimately lead a human to disastrous consequences. As patients display a high rate of relapse, prevention at an early stage can be an effective restraint.
arxiv  

Generalized Cubic Model for BaTiO$_3$-like Ferroelectric Substance [PDF]

, 2006
We propose an order-disorder type microscopic model for BaTiO$_3$-like Ferroelectric Substance. Our model has three phase transitions and four phases. The symmetry and directions of the polarizations of the ordered phases agree with the experimental results of BaTiO$_3$.
arxiv   +1 more source

Cariprazine in Bipolar Disorder and Substance Use: A Dual Approach to Treatment?

Pharmaceuticals
Bipolar disorder (BD) is characterized by recurrent episodes of mania, hypomania, and depression and is often complicated by comorbid substance use disorders (SUDs).
Simone Pardossi, Alessandro Cuomo, Despoina Koukouna, Mario Pinzi, Andrea Fagiolini   +4 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Externalizing disorders and substance use: empirically derived subtypes in a population-based sample of adults. [PDF]

, 2014
PURPOSE: Attention-deficit/hyperactivity disorder (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD) are common externalizing disorders of childhood. The common effects of these disorders on substance abuse need further investigation.
Ajdacic-Gross, V., Castelao, E., Müller, M., Preisig, M., Rodgers, S., Rössler, W.   +5 more
core   +2 more sources

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Perception, experience, and practice of Iraqi community pharmacists towards customers with substance use disorder

SAGE Open Medicine
Background: Pharmacists are healthcare professionals who frequently encounter individuals struggling with addiction in their day-to-day practice. Studies critique pharmacists’ competence in the detection, prevention, and management of substance use ...
Ehab Mudher Mikhael, Nisreen Jumaah Jebur, Mohammed Yawuz Jamal, Tabarak Arkan Hameed   +3 more
doaj   +1 more source

Preventable hospitalizations among adult Medicaid beneficiaries with concurrent substance use disorders

Preventive Medicine Reports, 2015
Objective: We aim to examine the relationships between substance use disorders and preventable hospitalizations for Ambulatory Care Sensitive Conditions among adult Medicaid beneficiaries.
Kit Sang Leung, Joe Parks, James Topolski   +2 more
doaj   +1 more source