Results 121 to 130 of about 1,878,278 (369)

Frequency of Parental Psychopathology in Children with Attention Deficit Hyperactivity Disorder [PDF]

open access: yes, 2012
Parental mental health concerns place children at a significantly greater risk of lower social, psychological and physical health than children in families not affected by mental illness.
Bhat, SM, Latha, KS, Nair, RB
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Neighborhood Conditions, Youth Exposure to Violence, and Substance Use [PDF]

open access: yes, 2020
Vast research has been conducted on exposure to violence and its consequences. Among the many consequences of exposure to violence is substance use. Using the Pathways to Desistance data, this study seeks to examine whether exposure to violence impacts ...
Jimenez, Ashley
core   +1 more source

Research on Etiological aspects of Dual Pathology [PDF]

open access: yes, 2010
Introducción: Es importante evaluar la interacción entre los antecedentes psicopatológicos familiares (AF), la dinámica familiar (DF), los trastornos de conducta, los trastornos por uso de sustancias y los trastornos de personalidad (TP).
Barea, Juan   +6 more
core   +1 more source

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Tunguska similar impacts and origin of life [PDF]

open access: yesarXiv, 2013
The author suggests new vision of mechanism of initiation of life on the planets after Tunguska similar impacts. This mechanism takes into consideration not only incoming cosmic organic substance but also information, which is connected to this substance.
arxiv  

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Substance Use Disorders in High‐Risk Adolescent Offspring [PDF]

open access: bronze, 1999
Sharon Milberger   +4 more
openalex   +1 more source

Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy

open access: yesFrontiers in Pharmacology, 2023
Scott John   +4 more
doaj   +1 more source

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