Results 71 to 80 of about 1,949,500 (369)

Mothering, substance use disorders and intergenerational trauma transmission : an attachment-based perspective [PDF]

, 2019
Background: A growing body of research underlines that interpersonal trauma in childhood leads to heightened susceptibility for substance use disorders (SUDs) in later life.
De Pauw, Sarah, Meulewaeter, Florien, Vanderplasschen, Wouter   +2 more
core   +2 more sources

OMAD: On-device Mental Anomaly Detection for Substance and Non-Substance Users [PDF]

arXiv, 2022
Stay at home order during the COVID-19 helps flatten the curve but ironically, instigate mental health problems among the people who have Substance Use Disorders. Measuring the electrical activity signals in brain using off-the-shelf consumer wearable devices such as smart wristwatch and mapping them in real time to underlying mood, behavioral and ...
arxiv  

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Defining Substance Use Disorders: Do We Really Need More Than Heavy Use? [PDF]

, 2017
Aims: The aim of the study was to explore whether the concept of heavy substance use over time can be used as definition of substance use disorder. Methods: Narrative review.
Anderson, P., Gmel, G., Gual, A., Kraus, L., Marmet, S., Nutt, D.J., Rehm, J., Room, R., Samokhvalov, A.V., Scafato, E., Trapencieris, M., Wiers, R.W.   +11 more
core  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Substance use disorders and risk of suicide in a general US population: a case control study

Addiction Science & Clinical Practice, 2020
Background Prior research suggests that substance use disorders (SUDs) are associated with risk of suicide mortality, but most previous work has been conducted among Veterans Health Administration patients.
Frances L. Lynch, Edward L. Peterson, Christine Y. Lu, Yong Hu, Rebecca C. Rossom, Beth E. Waitzfelder, Ashli A. Owen-Smith, Samuel Hubley, Deepak Prabhakar, L. Keoki Williams, Arne Beck, Gregory E. Simon, Brian K. Ahmedani   +12 more
doaj   +1 more source

The prevalence of subthreshold psychiatric symptoms and associations with alcohol and substance use disorders: from a nationally representative survey of 36,309 adults

BMC Psychiatry, 2022
Background Our aim was to describe a broad number of subthreshold psychiatric symptoms (SPS) in a nationally representative population and evaluate associations with substance use.
Jeremy C. S. Johnson, Gerard J. Byrne, Anita M. Pelecanos   +2 more
doaj   +1 more source

Continuing care groups: long term treatment of substance use disorders [PDF]

, 2014
Master's Project (M.Ed.) University of Alaska Fairbanks, 2014Substance use disorders are chronic diseases that affect individuals, families, and communities. These illnesses frequently require several courses of treatment to achieve abstinence. Inpatient
Foote, Olivia
core  

Words Matter: Reducing Stigma in Online Conversations about Substance Use with Large Language Models [PDF]

In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing (EMNLP); pages 9139 - 9156
Stigma is a barrier to treatment for individuals struggling with substance use disorders (SUD), which leads to significantly lower treatment engagement rates. With only 7% of those affected receiving any form of help, societal stigma not only discourages individuals with SUD from seeking help but isolates them, hindering their recovery journey and ...
arxiv   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source