Results 91 to 100 of about 129,849 (338)

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, EarlyView.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

The subcortical cocktail problem; mixed signals from the subthalamic nucleus and substantia nigra.

PLoS ONE, 2015
The subthalamic nucleus and the directly adjacent substantia nigra are small and important structures in the basal ganglia. Functional magnetic resonance imaging studies have shown that the subthalamic nucleus and substantia nigra are selectively ...
Gilles de Hollander, Max C Keuken, Birte U Forstmann   +2 more
doaj   +1 more source

Untersuchung eines möglichen neuroprotektiven Effektes der Kainsäure- und Chinolinsäureläsion des Nucleus subthalamicus auf dopaminerge Neurone der Substantia nigra im 6-Hydroxydopamin- und im 3-Nitropropionsäure-Parkinson-Tiermodell der Ratte. [PDF]

, 2005
Das idiopathische Parkinson-Syndrom zählt zu den häufigsten neuro¬logischen Erkrankungen. Der ihm zugrundeliegende progressive Verlust dopaminerger nigrostriataler Neurone in der Pars compacta der Substantia nigra und das daraus resultierende ...
Oertel, W.-H., Prof. Dr. med., Schiel, Sebastian Julius   +1 more
core   +1 more source

Acute Effects of the 5‐Hydroxytryptamine Type 4 Receptor Agonist Mosapride on Pharyngeal Swallowing Physiology in Adults

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The 5‐hydroxytryptamine type 4 receptor agonist mosapride is known to modulate esophageal peristalsis and enhance lower esophageal sphincter compliance. However, its impact on oropharyngeal swallowing physiology remains insufficiently characterized.
Shu‐Wei Liang, Jui‐Sheng Hung, Taher Omari, Ming‐Wun Wong, Wei‐Yi Lei, Tso‐Tsai Liu, Chih‐Hsun Yi, Chien‐Lin Chen   +7 more
wiley   +1 more source

Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson’s disease models

Neural Regeneration Research, 2018
Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson’s disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition ...
Lan-Xiang Liu, Dan Du, Zhan-Qiu Wang, Yuan Fang, Tao Zheng, Yan-Chao Dong, Qing-Lei Shi, Min Zhao, Fang Xiao, Juan Du   +9 more
doaj   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease

npj Parkinson's Disease
Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons. Exercise has been reported to slow the clinical progression of PD.
Bart de Laat, Jocelyn Hoye, Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan, Dustin W. Wooten, Xiaomeng Zhang, Thanh D. Nguyen, Jose Key, Giulia Colonna, Yiyun Huang, Nabeel Nabulsi, Amar Patel, David Matuskey, Evan D. Morris, Sule Tinaz   +16 more
doaj   +1 more source

Intracerebroventricularly-administered 1-methyl-4-phenylpyridinium ion and brain-derived neurotrophic factor affect catecholaminergic nerve terminals and neurogenesis in the hippocampus, striatum and substantia nigra

Neural Regeneration Research, 2018
Parkinson's disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra. A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
Jun-Fang Chen, Man Wang, Ying-Han Zhuang, Thomas Behnisch   +3 more
doaj   +1 more source

Parkinsonism and Dystonia Are Prevalent and Concomitant Movement Disorders in a Cohort of Patients with Rett Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Rett syndrome (RTT) is a rare neurodevelopmental disorder linked with MECP2 variants, frequently presenting with movement disorders (MDs). Objectives This study examined the frequency, types, and associations of MDs with RTT characteristics and severity.
Silvia Boeri, Giulia Prato, Maria Grazia Calevo, Silvia Casabona, Lino Nobili, Elisa De Grandis   +5 more
wiley   +1 more source