Results 111 to 120 of about 134,010 (347)

Spiked human substantia nigra proteome data set for use as a spectral library for protein modelling and protein mapping

Data in Brief, 2019
This article describes a mass spectrometric data set generated from human substantia nigra tissue that was spiked with iRT peptides. The data set can be used as a spectral library for analysis of the human brain; especially for analysis of human ...
Simone Steinbach, Bettina Serschnitzki, Manfred Gerlach, Katrin Marcus, Caroline May   +4 more
doaj   +1 more source

Extended Anatomical Grading in Diffuse Axonal Injury Using MRI: Hemorrhagic Lesions in the Substantia Nigra and Mesencephalic Tegmentum Indicate Poor Long-Term Outcome [PDF]

, 2016
Sami Abu Hamdeh, Niklas Marklund, Marianne Lannsjö, Tim Howells, Raili Raininko, Johan Wikström, Per Enblad   +6 more
openalex   +1 more source

Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson’s disease [PDF]

, 2022
Anand Tekriwal, Gidon Felsen, Steven Ojemann, Aviva Abosch, John A. Thompson   +4 more
openalex   +1 more source

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine, Melissa N. Veendijk, Jessie Nijman, Mieneke C. M. Luijendijk, Inge G. Wolterink‐Donselaar, Frank J. Meye, Roger A. H. Adan   +6 more
wiley   +1 more source

Intracerebroventricularly-administered 1-methyl-4-phenylpyridinium ion and brain-derived neurotrophic factor affect catecholaminergic nerve terminals and neurogenesis in the hippocampus, striatum and substantia nigra

Neural Regeneration Research, 2018
Parkinson's disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra. A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ...
Jun-Fang Chen, Man Wang, Ying-Han Zhuang, Thomas Behnisch   +3 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

Frontiers in Endocrinology
Glucocorticoids are key executors of the physiological response to stress. Previous studies in mice showed that the androgen receptor (AR) influenced the transcriptional outcome of glucocorticoid treatment in white and brown adipocytes and in the liver ...
Jorge Miguel Amaya, Jorge Miguel Amaya, Hetty C. M. Sips, Hetty C. M. Sips, Eva M. G. Viho, Eva M. G. Viho, Jan Kroon, Jan Kroon, Onno C. Meijer, Onno C. Meijer   +9 more
doaj   +1 more source

Differences in brain pathological changes between rotenone and 6-hydroxydopamine Parkinson’s disease models

Neural Regeneration Research, 2018
Rotenone and 6-hydroxydopamine are two drugs commonly used to generate Parkinson’s disease animal models. They not only achieve degenerative changes of dopaminergic neurons in the substantia nigra, but also satisfy the requirements for iron deposition ...
Lan-Xiang Liu, Dan Du, Zhan-Qiu Wang, Yuan Fang, Tao Zheng, Yan-Chao Dong, Qing-Lei Shi, Min Zhao, Fang Xiao, Juan Du   +9 more
doaj   +1 more source

Teaching NeuroImages: Parkinsonism Secondary to a Metastatic Lesion Involving the Substantia Nigra [PDF]

, 2020
Kosei Hirata, Takanori Yokota, Yoshiharu Miura   +2 more
openalex   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source