Disease modifying therapy for multiple system atrophy – Parkinsonian Type [PDF]
, 2017 BACKGROUND: Multiple System Atrophy –Parkinsonian Type (MSA-P) is a rare, rapidly progressive neurodegenerative disease without any current treatment.
Dwyer, Sean Sullivan
core
Differential Effects of Tau Stage, Lewy Body Pathology, and Substantia Nigra Degeneration on18F-FDG PET Patterns in Clinical Alzheimer Disease [PDF]
, 2022 Jesús Silva‐Rodríguez +6 more
openalex +1 more source
Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances
Mass Spectrometry Reviews, EarlyView.Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley +1 more source
Immunocytochemical localization of glutamate decarboxylase in rat substantia nigra [PDF]
, 1976 l-Glutamate decarboxylase (GAD, EC 4.1.1.15), the enzyme which catalyzes the α-decarboxylase of l-glutamate to form γ-aminobutyric acid (GABA), was localized both light and electron microscopically in rat substantia nigra by an immunoperoxidase method ...
Barber, R +4 more
core +1 more source
Movement Disorders Associated with 22q11.2 Microdeletion: A Scoping Review
Movement Disorders Clinical Practice, EarlyView.Abstract Background Movement disorders have recently emerged as important neurologic manifestations of the 22q11.2 microdeletion that affects nearly one in every 2000 live births. Objective We aimed to map the existing evidence regarding the spectrum, diagnosis and treatment, and etiopathogenesis of movement disorders associated with 22q11.2 ...
Nikolai Gil D. Reyes +6 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's Disease (PD) is a progressive neurodegenerative disorder primarily characterized by motor symptoms such as tremors, rigidity, and bradykinesia. Structural brain changes, including atrophy in the midbrain, basal ganglia, and cortical regions such as the frontal and temporal lobes, are observed in advanced stages.
Suraiya Mangra +5 more
wiley +1 more source
Auditory oddball responses in the human subthalamic nucleus and substantia nigra pars reticulata
Neurobiology of DiseaseThe auditory oddball is a mainstay in research on attention, novelty, and sensory prediction. How this task engages subcortical structures like the subthalamic nucleus and substantia nigra pars reticulata is unclear.
Dallas Leavitt +8 more
doaj +1 more source
GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease. [PDF]
, 2019 While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated.
Aras, Radha +5 more
core +1 more source
A Cognitive Architecture for the Implementation of Emotions in Computing Systems
, 2016 In this paper we present a new neurobiologically-inspired affective cognitive architecture: NEUCOGAR (NEUromodulating COGnitive ARchitecture). The objective of NEUCOGAR is the identification of a mapping from the influence of serotonin, dopamine and ...
Distefano, Salvatore +5 more
core +1 more source