Results 131 to 140 of about 86,799 (302)

Effect of Electroacupuncture Intervention on Levels of SOD,GSH,GSH-Px,MDA,and Apoptosis of Dopaminergic Neurons in Substantia Nigra in Rats with Parkinson's Disease

针刺研究, 2014
Objective To observe the effect of electroacupuncture(EA)on superoxide(SOD),glutathione peroxidase(GSH-Px)activity,contents of glutathione(GSH)and malondiadehyde(MDA),and expression of tyrosine hydroxylase(TH)and apoptosis of Dopaminergic(DA)neurons in ...
LI Jing, WANG Li-na, XIAO Hong-ling, LI Xia, YANG Ji-jun   +4 more
doaj  

Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies

Scientific Reports
Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) in the substantia nigra, from MRI-based quantitative
Oliver C. Kiersnowski, Pietro Mattioli, Lucia Argenti, Laura Avanzino, Francesco Calizzano, Andrea Diociasi, Laura Falcitano, Chunlei Liu, Mattia Losa, Federico Massa, Silvia Morbelli, Beatrice Orso, Elisa Pelosin, Stefano Raffa, Matteo Pardini, Dario Arnaldi, Luca Roccatagliata, Mauro Costagli   +17 more
doaj   +1 more source

Reduced Dopamine Transporter Uptake in Dentatorubral‐Pallidoluysian Atrophy

Movement Disorders Clinical Practice, EarlyView.
Kei Okuba, Shugo Fujita, Hitoshi Kawasaki, Genko Oyama   +3 more
wiley   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Substantia nigra degeneration in motor neurone disease: a quantitative study.

, 1992
There is increasing evidence of degeneration of nerve cells other than motor neurones in sporadic motor neurone disease (MND). Sporadic MND is occasionally associated with Parkinsonism.
Blumbergs, P C, Burrow, J N
core  

Dopamine and dopamine-quinones toxicity in Parkinson's disease: cellular models revealing a possible role for superoxide dismutases [PDF]

, 2013
Parkinson’s disease is a widespread neurodegenerative disorder that affect 2% of the population above the age of 60. The hallmark of the pathology is the preferential degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the ...
Cappellini, Rekha
core  

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

POLG‐Related Parkinsonism with Good Response to Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Evdokia Efthymiou, Fabian Büchele, Sujitha Mahendran, Lennart Stieglitz, Bettina Balint   +4 more
wiley   +1 more source

Disease‐Duration–Specific Percentiles for Prospective Subtyping of Parkinson's Disease: A PPMI‐Based Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is clinically heterogeneous, with variable progression rates that complicate clinical trial design. The data‐driven diffuse malignant (DM), intermediate (IM), and mild‐motor predominant (MMP) subtyping model has prognostic value but lacks disease duration–specific thresholds for prospective use in disease ...
Ahmed Negida, Nitai Mukhopadhyay, Brian D. Berman, Seyed‐Mohammad Fereshtehnejad, Matthew J. Barrett   +4 more
wiley   +1 more source

The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2019
Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress.
Toraj Mohammad zamani, Ahmadreza Movahedi, Elahe Arab ameri   +2 more
doaj