Results 131 to 140 of about 73,544 (253)

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Radiomic Signature of the Substantia Nigra on Neuromelanin-Sensitive MRI Distinguishes Bipolar II Disorder From Unipolar Depression. [PDF]

Brain Behav
Kuai X, Shao D, Wang S, Zhang F, Zhang S, Wang X, Wang J.   +6 more
europepmc   +1 more source

7 Tesla MRI with Quantitative Susceptibility Mapping: qualitative grading and quantitative focal measurements of the substantia nigra as a potential biomarker for Parkinson's disease. [PDF]

Neuroradiology
Unsgård RG, Stige KE, Kristoffersen AL, Goa PE, Tzoulis C, Berntsen EM.   +5 more
europepmc   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Motor cortex directly excites the substantia nigra pars reticulata, the basal ganglia output nucleus. [PDF]

Nat Commun
Thompson WS, Wekwejt P, Grillner S, Silberberg G.   +3 more
europepmc   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

Sustained activity of human substantia nigra neurons reflect prior rewards. [PDF]

iScience
Imtiaz Z, Kato A, Kopell BH, Qasim SE, Davis AN, Martinez LN, Heflin M, Kulkarni K, Morsi A, Charney AW, Gu X, Saez I.   +11 more
europepmc   +1 more source

Knowledge Work as a Condition of Accumulation in the Pesticide Industry: Syngenta's Defence of Paraquat

Journal of Agrarian Change, EarlyView.
ABSTRACT What do pesticide companies do to keep their products on the market despite strong societal and scientific critiques of their environmental and health risks? This paper examines the herbicide paraquat, one of the most controversial pesticides, from the early 1960s to the present.
Kees Jansen
wiley   +1 more source

Tissue Effects of the Mitochondrial Division Inhibitor Mdivi-1 on the Substantia Nigra in a Laboratory Model of Dopaminergic System Damage. [PDF]

Int J Mol Sci
Egorova AV, Voronkov DN, Ryabova MS, Stavrovskaya AV, Olshansky AS, Pavlova AK, Baranich TI, Kharlamov DA, Sukhorukov VS.   +8 more
europepmc   +1 more source

Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications

Experimental Physiology, EarlyView.
Abstract Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking brain, behaviour and autonomic responses.
Denisa Adina Zamfira, Tommaso Fassina, Kamil Zaworski, Elisa Carlino, Giacomo Rossettini   +4 more
wiley   +1 more source