Results 121 to 130 of about 73,544 (253)

Lactoperoxidase is a candidate for mediating neuromelanin formation in the human substantia nigra. [PDF]

Proc Natl Acad Sci U S A
Tóth ZE, Baráth M, Pape VFS, Sípos K, Boros AP, Durst M, Várnai P, Sirokmány G, Geiszt M.   +8 more
europepmc   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Chronic Methamphetamine Administration Increases Mitochondrial Density and Impairs Mitochondrial Function in the Substantia Nigra Pars Compacta. [PDF]

J Neurochem
Bhowmik A, Wilking JA, Alshareef D, Campbell C, Graves SM.   +4 more
europepmc   +1 more source

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

Brain Pathology, EarlyView.
This is the first report of neuropathology in biallelic RFC1 expansion‐associated Parkinson’s disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bilateral Vestibular Areflexia) features were absent.
Jussi Sipilä, Tuomas Rauramaa, Laura Kytövuori, Kari Majamaa   +3 more
wiley   +1 more source

Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt–Jakob disease cohort

Brain Pathology, EarlyView.
Systematic neuropathological screening of 212 patients with Creutzfeldt–Jakob disease (55% women) identified chronic traumatic encephalopathy in three cases (1.4%), all men with a history of contact sports. These findings represent the first neuropathologically confirmed chronic traumatic encephalopathy cases reported in Spain.
Lluc Bertran, Iban Aldecoa, Arlène Sindikubwabo, Núria Vidal, Rafael Blesa, Mercè Martínez‐Corral, Carlos Nos, Verónica Santiago, Andrea González, Álex Iranzo, Christopher J. Nowinski, Ann C. McKee, Raquel Sánchez Valle, Laura Molina‐Porcel   +13 more
wiley   +1 more source

High molecular weight insoluble parkin in the substantia nigra of patients with idiopathic Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Tremblay C, Pshevorskiy L, Cottez RJ, Denis HL, Emond V, Morissette M, Rajput AH, Di Paolo T, Rajput A, Calon F.   +9 more
europepmc   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

One-Year Substantia Nigra R 2 * Changes across Parkinson's Disease Stages. [PDF]

Mov Disord
Coussediere C, Pereira B, Devos D, Lehéricy S, Peran P, Durand E, Chassain C, Houeto JL, Benatru I, Colin O, Rascol O, Ory-Magne F, Brefel-Courbon C, Maindreville AD, Vidailhet M, Corvol JC, Frismand S, Schmitt E, Defebvre L, Carriere N, Meissner WG, Boraud T, Remy P, Moro E, Thobois S, Geny C, Bonny JM, Durif F, Marques A, MPI‐R2* study group.   +29 more
europepmc   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function. [PDF]

Brain Commun
Krohn F, Sarkar M, Schütze H, Iliopoulos P, Penalba-Sánchez L, Hämmerer D, Yakupov R, Lüsebrink F, Spottke A, Schneider A, Roy N, Incesoy E, Heneka M, Kilimann I, Kleineidam L, Teipel SJ, Brosseron F, Goerss D, Glanz W, Schmid M, Rostamzadeh A, Wagner M, Fliessbach K, Jessen FO, Düzel E, Betts MJ.   +25 more
europepmc   +1 more source