Results 101 to 110 of about 86,799 (302)

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Angiogenin is expressed in TH-positive neurons in the substantia nigra after viral injection.

, 2013
A. An AAV2-Ang injected mouse was sacrificed eight weeks after injection and stained with a primary antibody against the V5 tag fused to angiogenin and a CY3-conjugated secondary antibody, demonstrating overexpression of angiogenin in the substantia ...
Trent U. Steidinger (284605), Huiping Ding (284607), David G. Standaert (177034), Sunny R. Slone (284606), Talene A. Yacoubian (284608)   +4 more
core   +1 more source

Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain

Frontiers in Endocrinology
Glucocorticoids are key executors of the physiological response to stress. Previous studies in mice showed that the androgen receptor (AR) influenced the transcriptional outcome of glucocorticoid treatment in white and brown adipocytes and in the liver ...
Jorge Miguel Amaya, Jorge Miguel Amaya, Hetty C. M. Sips, Hetty C. M. Sips, Eva M. G. Viho, Eva M. G. Viho, Jan Kroon, Jan Kroon, Onno C. Meijer, Onno C. Meijer   +9 more
doaj   +1 more source

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders

JCPP Advances, EarlyView.
Abstract Background Evidence indicates substantial genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder‐specific genetic architecture and patterns of comorbidity. Methods We applied genomic structural equation modeling to genome‐wide association study summary statistics from 11 ...
Engin Keser, Wangjingyi Liao, Andrea G. Allegrini, Kaili Rimfeld, Thalia C. Eley, Robert Plomin, Margherita Malanchini   +6 more
wiley   +1 more source

Reduction of alpha-synuclein oligomers in preclinical models of Parkinson’s disease by electrical stimulation in vitro and deep brain stimulation in vivo

Brain Stimulation
Background: Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD).
Eun Jung Lee, David Hernán Aguirre-Padilla, Anton Fomenko, Grishma Pawar, Minesh Kapadia, Jimmy George, Andres M. Lozano, Clement Hamani, Lorraine V. Kalia, Suneil K. Kalia   +9 more
doaj   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

Oxytocin Receptor Binding in the Substantia Nigra in Schizophrenia

, 2023
Schizophrenia is a chronic, psychiatric disorder characterized by hallucinations, delusions, cognitive deficits, and social cognitive impairments. Although antipsychotic drugs are typically effective in treating psychotic symptoms in schizophrenia, the ...
Snowden, Ariel
core   +1 more source

Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis

npj Parkinson's Disease
Parkinson’s disease is a highly heterogeneous disorder, encompassing a complex spectrum of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms.
Joshua Harvey, Adam R. Smith, Luke S. Weymouth, Rebecca G. Smith, Isabel Castanho, Leon Hubbard, Byron Creese, Catherine Bresner, Nigel Williams, Ehsan Pishva, Katie Lunnon   +10 more
doaj   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance

, 2019
In Parkinson's disease, degeneration of substantia nigra dopaminergic neurons is accompanied by damage on other neuronal systems. A severe denervation is for example seen in the locus coerulean noradrenergic system.
Pelegrina-Hidalgo, Noelia,, Gerhardt, Greg A, Stenmark Persson, Rasmus,, Strömberg, Ingrid,, af Bjerkén, Sara,, Karalija, Nina,, Barkander, Anna,, Virel, Ana,   +7 more
core   +1 more source