Annals of Neurology, EarlyView.Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng +3 more
wiley +1 more source
Effect of ghrelin gene knockout on the postsynaptic potential of dopaminergic neurons in the substantia nigra of mice [PDF]
精准医学杂志Objective To study the effect of ghrelin gene knockout on the postsynaptic potential of dopaminergic neurons in the substantia nigra of mice. Methods Substantia nigra tissue was taken from 10-week-old ghrelin-/- male mice (ghrelin-/- group) and their ...
LIU Jing, LI Huanhuan, JIAO Qian, CHEN Xi, JIANG Hong, DU Xixun
doaj +1 more source
The substantia Nigra pars compacta and temporal processing [PDF]
, 2006 The basal ganglia and cerebellum are considered to play a role in timing, although their differential roles in timing remain unclear. It has been proposed that the timing of short milliseconds-range intervals involves the cerebellum, whereas longer ...
Dirnberger, G. +3 more
core
Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models [PDF]
, 2009 This study demonstrates the application of quantitative elemental bio-imaging for the determination of the distribution Cu, Mn, Fe and Zn in Parkinsonism mouse model brains.
Bush, AI +9 more
core +1 more source
Diffusion MRI and α‐Synuclein Seed Amplification Status in Parkinson's Disease
Annals of Neurology, EarlyView.Objective Positive α‐synuclein seed amplification assay (SAA) is a biomarker found in most people with Parkinson's disease (PD). We explored if free‐water (FW) imaging detects microstructural differences in the brains of patients with early PD with SAA+ or SAA– status.
Shannon Y. Chiu +145 more
wiley +1 more source
GABAergic nerve terminals decrease in the substantia nigra following hemitransections of the striatonigral and pallidonigral pathways. [PDF]
, 1980 Glutamic acid decarboxylase (GAD), the enzyme that synthesizes the neurotransmitter, GABA, was immunocytochemically localized in axon terminals as well as in small and medium-sized neurons of the rat substantia nigra. The pattern formed by GAD-containing
Ribak, CE, Roberts, E, Vaughn, JE
core
Learning Contextual Reward Expectations for Value Adaptation [PDF]
, 2018 Substantial evidence indicates that subjective value is adapted to the statistics of reward expected within a given temporal context. However, how these contextual expectations are learned is poorly understood.
Chew, B. +3 more
core +2 more sources
Moving beyond neurophobia to cultivate the neuroquisitive learner
Anatomical Sciences Education, EarlyView.Abstract “Neurophobia,” a pervasive fear of the neurological sciences, poses a significant barrier in medical education, affecting learners and physicians worldwide. Its consequences are far‐reaching, contributing to a limited neurology workforce and diminished confidence among non‐specialists in managing neurological conditions.
Joanna R. Appel +1 more
wiley +1 more source
The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development
MoleculesThis review explores the essential roles of purine metabolism including the catabolic product, uric acid, in the development of dopaminergic neurons of the substantia nigra pars compacta. The high energy requirements of the substantia nigra pars compacta
Lauren N. Mileti, James D. Baleja
doaj +1 more source
Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward [PDF]
, 2011 Dopamine release in cortical and subcortical structures plays a central role in reward-related neural processes. Within this context, dopaminergic inputs are commonly assumed to play an activating role, facilitating behavioral and cognitive operations ...
Böhler, Nico +6 more
core +2 more sources