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Neuromelanin, iron and MRI measurements in midbrain tissues of Parkinson’s and Alzheimer’s subjects [PDF]

Frontiers in Aging Neuroscience
BackgroundIn Parkinson’s disease, decreased neuromelanin and increased Fe concentrations derive from the loss of neuromelanin-containing neurons in the substantia nigra, which is spared in Alzheimer’s disease.
Fabio A. Zucca, Clifford M. Cassidy, Clifford M. Cassidy, Michela Sturini, Lauri Tuominen, Fulvio Adorni, Victoria Cheung, Luigi Casella, David Sulzer, David Sulzer, Gianni Pezzoli, Gianni Pezzoli, Ioannis U. Isaias, Ioannis U. Isaias, Guillermo Horga, Guillermo Horga, Luigi Zecca, Luigi Zecca   +17 more
doaj   +2 more sources

SN/VTA neuromelanin signal is associated with subclinical paranoia irrespective of familial risk for psychosis [PDF]

Schizophrenia
Subclinical paranoia is present in the relatives of patients with psychosis but it is also relatively common in the general population. Dopamine neurotransmission is increased in people with psychosis and is linked with positive symptoms, such as ...
Rami Hamati, Nour Kanaa, Bianca Chidiac, Synthia Guimond, Clifford Cassidy, Lauri Tuominen   +5 more
doaj   +2 more sources

Melanin and Neuromelanin in Humans: Insights Across Health, Aging, Diseases, and Unexpected Aspects of Fungal Melanogenesis [PDF]

Biomolecules
Melanin pigments are ubiquitous biopolymers across diverse life forms and play multifaceted roles in cellular defense and environmental adaptation. The specialized neuromelanin in human brains accumulates mainly within catecholaminergic neurons of the ...
Kathleen Hatch, Erin K. Murphy, Radamés J. B. Cordero, Diego Iacono   +3 more
doaj   +2 more sources

The Enigma of Neuromelanin: How Animal Models Can Help Researchers to Understand the Link Between Pigments and Neurodegeneration [PDF]

Biomedicines
Neuromelanin granules (NMGs) are the characteristic hallmark of the human substantia nigra pars compacta (SNpc). Although especially NMG-containing neurons are affected by neurodegeneration in Parkinson’s disease (PD), the complex biology of NMGs is not ...
Svenja Esser, Maximilian Hausherr, Katrin Marcus-Alic   +2 more
doaj   +2 more sources

Exposure to Mitochondrial Toxins: An In Vitro Study of Energy Depletion and Oxidative Stress in Driving Dopaminergic Neuronal Death in MN9D Cells [PDF]

Toxics
Mitochondrial dysfunction is a key contributor to neurodegeneration, particularly in Parkinson’s disease (PD), where dopaminergic neurons being highly metabolically active are vulnerable to oxidative stress and bioenergetic failure.
Oluwatosin Adefunke Adetuyi, Kandatege Wimalasena   +1 more
doaj   +2 more sources

Neuromelanin-targeted 18F-P3BZA PET/MR imaging of the substantia nigra in rhesus macaques [PDF]

EJNMMI Research
Background Neuromelanin is mostly located in dopaminergic neurons in the substantia nigra (SN) pars compacta, and can be detected by magnetic resonance imaging (MRI). It is a promising imaging-base biomarker for neurological diseases.
Hongyan Feng, Ning Tu, Ke Wang, Xiaowei Ma, Zhentao Zhang, Zhongchun Liu, Zhen Cheng, Lihong Bu   +7 more
doaj   +2 more sources

Absolute quantification of neuromelanin in formalin-fixed human brains using absorbance spectrophotometry.

PLoS ONE, 2023
Parkinson's disease is characterised by a visual, preferential degeneration of the pigmented neurons in the substantia nigra. These neurons are pigmented by neuromelanin which decreases in Parkinson's disease.
Dipshay Avi Chand, Miriam Scadeng, Birger Victor Dieriks   +2 more
doaj   +1 more source

Quantitative iron–neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification

Frontiers in Aging Neuroscience, 2023
BackgroundNeuromelanin- and iron-sensitive MRI studies in Parkinson's disease (PD) are limited by small sample sizes and lack detailed clinical correlation.
Septian Hartono, Septian Hartono, Robert Chun Chen, Robert Chun Chen, Thomas Welton, Thomas Welton, An Sen Tan, Weiling Lee, Peik Yen Teh, Celeste Chen, Wenlu Hou, Wei Ping Tham, Ee Wei Lim, Kumar M. Prakash, Yao-Chia Shih, Yao-Chia Shih, Kuan Jin Lee, Louis C. S. Tan, Louis C. S. Tan, Eng King Tan, Eng King Tan, Ling Ling Chan, Ling Ling Chan   +22 more
doaj   +1 more source

Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase

Antioxidants, 2022
Glutathione is an important antioxidant that plays a crucial role in the cellular protection against oxidative stress and detoxification of electrophilic mutagens, and carcinogens.
Juan Segura-Aguilar, Patricia Muñoz, Jose Inzunza, Mukesh Varshney, Ivan Nalvarte, Bengt Mannervik   +5 more
doaj   +1 more source

An investigation of neuromelanin distribution in substantia nigra and locus coeruleus in patients with Parkinson’s disease using neuromelanin-sensitive MRI

BMC Neurology, 2023
Loss of neuromelanin in the midbrain is known in Parkinson’s disease(PD), which can now be directly detected by neuromelanin-sensitive MRI(NM-MRI). This case-control study was to investigate the distribution of neuromelanin in the substantia nigra(SN ...
Qiang Liu, Pan Wang, Chenghe Liu, Feng Xue, Qian Wang, Yuqing Chen, Ruihua Hou, Teng Chen   +7 more
doaj   +1 more source