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Locus coeruleus degeneration is associated with cortical tau deposition and cognitive decline in older adults at familial risk of Alzheimer's disease. [PDF]
Alzheimers DementAbstract INTRODUCTION The locus coeruleus (LC) is among the first sites of tau pathology in Alzheimer's disease (AD) and may seed neocortical tau. METHODS We used longitudinal neuromelanin‐sensitive MRI to assess LC integrity in vivo in a cohort of cognitively unimpaired older adults with familial risk of AD in relation to tau and amyloid positron ...
Wearn A +14 more
europepmc +2 more sources
Tomography, 2021 The presence of a swallow-tail sign in the nigrosome-1 with hyperintense signal shown on the susceptibility-weighted imaging (SWI) has been shown to be sensitive in detecting the abnormal iron deposits in this area.
Tzu-Wei Lee +8 more
doaj +1 more source
Quantitative profiling of the human substantia nigra proteome from laser-capture microdissected FFPE tissue [PDF]
, 2020 Laser-capture microdissection (LCM) allows the visualization and isolation of morphologically distinct subpopulations of cells from heterogeneous tissue specimens.
Griesser, Eva +5 more
core +3 more sources
Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging
European Journal of Histochemistry, 2021 Neuromelanin (NM) is a dark polymer pigment produced in certain populations of catecholaminergic neurons in the brain. It is present in various areas of the human brain, most often in the substantia nigra (SN) pars compacta and the locus coeruleus, the ...
Dmitrii E. Korzhevskii +5 more
doaj +1 more source
Chinese Journal of Magnetic Resonance, 2023 Three-dimensional (3D) gradient recalled echo (GRE) sequence with magnetization transfer (MT) can simultaneously image neuromelanin and magnetic susceptibility.
CHEN Mengying +5 more
doaj +1 more source
Locus coeruleus complex of the family Delphinidae [PDF]
, 2018 The locus coeruleus (LC) is the largest catecholaminergic nucleus and extensively projects to widespread areas of the brain and spinal cord. The LC is the largest source of noradrenaline in the brain.
Arbelo, Manuel +6 more
core +2 more sources
Frontiers in Bioengineering and Biotechnology, 2019 Neuromelanin is present in the cathecolaminergic neuron cells of the substantia nigra and locus coeruleus of the midbrain of primates. Neuromelanin plays a role in Parkinson's disease (PD).
Ri Xu, Francesca Soavi, Clara Santato
doaj +1 more source
Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]
, 2013 The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti +53 more
core +2 more sources
Parkinson's disease: autoimmunity and neuroinflammation [PDF]
, 2016 Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO +9 more
core +1 more source
A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy
BMC Neurology, 2020 Background Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders.
Rita Moiron Simões +12 more
doaj +1 more source