Results 41 to 50 of about 8,760 (227)
Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator
Neural Regeneration Research, 2017 The loss of pigmented neurons from the human brain has long been the hallmark of Parkinson's disease (PD). Neuromelanin (NM) in the pre-synaptic terminal of dopamine neurons is emerging as a primary player in the etiology of neurodegenerative disorders ...
Robert L Haining, Cindy Achat-Mendes
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Frontiers in Psychiatry, 2021 Background: Psychiatry is in urgent need of reliable biomarkers. Novel neuromelanin-sensitive magnetic resonance imaging (NM-MRI) sequences provide a time-efficient and non-invasive way to investigate the human brain in-vivo.
Lara Wieland +6 more
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Data in BriefThe current dataset aims to support and enhance the research reliability of neuromelanin regions in the brainstem, such as locus coeruleus (LC), by offering raw neuromelanin-sensitive images.
Tae-Ho Lee +4 more
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Contrast mechanisms associated with neuromelanin‐MRI [PDF]
Magnetic Resonance in Medicine, 2016 PurposeTo investigate the physical mechanisms associated with the contrast observed in neuromelanin MRI.MethodsPhantoms having different concentrations of synthetic melanins with different degrees of iron loading were examined on a 3 Tesla scanner using relaxometry and quantitative magnetization transfer (MT).ResultsConcentration‐dependent T1 and T2 ...
Trujillo P +10 more
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Conductive atomic force microscopy data from substantia nigra tissue
Data in Brief, 2019 Ferritin and neuromelanin are present within the dopamine neurons of the substantia nigra pars compacta (SNc), and ferritin is also distributed in the intercellular regions of those neurons.
Christopher J. Rourk
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Toothed Whales Have Black Neurons in the Blue Spot
Veterinary Sciences, 2022 Neuromelanin (NM) is a dark polymer pigment that is located mostly in the human substantia nigra, and in the locus ceruleus, referred to as “the blue spot”.
Simona Sacchini +8 more
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EPR Investigations of Model Neuromelanins
Acta Physica Polonica A, 2000 The aim of this work was to compare free radical properties of some model neuromelanins obtained from dopamine and its mixture with 5-S-cysteinyldopamine in various molar ratios. The EPR method was used in these investigations; the samples were detected at X and K bands.
Skrzypek, Danuta +2 more
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Schizophrenia, 2023 Abstract Changes in dopamine and fronto-striato-thalamic (FST) circuit functional connectivity are prominent in schizophrenia. Dopamine is thought to underlie connectivity changes, but experimental evidence for this hypothesis is lacking. Previous studies examined the association in some of the connections using positron emission tomography ...
Sunah Choi +8 more
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Frontiers in Neuroimaging, 2023 IntroductionThe brainstem locus coeruleus (LC) influences a broad range of brain processes, including cognition. The so-called LC contrast is an accepted marker of the integrity of the LC that consists of a local hyperintensity on specific Magnetic ...
Alexandre Berger +23 more
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Annals of Neurology, EarlyView.Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng +3 more
wiley +1 more source