Results 51 to 60 of about 8,760 (227)

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates [PDF]

, 2016
Accumulation of alpha-synuclein (α-syn) in Lewy bodies and neurites of midbrain dopamine neurons is diagnostic for Parkinson’s disease (PD), leading to the proposal that PD is a toxic gain-of-function synucleinopathy.
D. Eugene Redmond, Fredric P. Manfredsson, Jack W. Lipton, Kathy Steece-Collier, Timothy J. Collier   +4 more
core   +2 more sources

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Black pancreatic neuro-endocrine tumor: A rare finding

Medical Journal of Dr. D.Y. Patil University, 2015
Pigmented lesions most commonly encountered in any organ are due to deposition of melanin in primary or metastatic malignant melanoma. Other less common pigments are lipofuscin and neuromelanin.
Shailja Puri Wahal, Neha Mohindroo, Shobla Mohindroo   +2 more
doaj   +1 more source

The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI [PDF]

, 2016
High field magnetic resonance imaging (MRI)-based delineation of the substantia nigra (SN) and visualization of its inner cellular organization are promising methods for the evaluation of morphological changes associated with neurodegenerative diseases ...
AI Blazejewska, C Mänz, D Mattes, DH Adler, DH Kwon, DW Chakeres, E Reiter, E Shibata, ES Manova, FA Zucca, H Benveniste, J Langley, K Schmierer, L Zecca, L Zecca, M Cosottini, M Cosottini, M Eapen, M Sasaki, M Sasaki, M Unser, MS Bolding, NI Keren, P Damier, RJ Dawe, S Baudrexel, S Kitao, S Lehéricy, S Lehéricy, ST Schwarz, Y Zhang   +30 more
core   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. [PDF]

, 2016
The ability to assess the distribution and extent of tau pathology in Alzheimer's disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies.
Aigbirhio, Franklin I, Allinson, Kieren SJ, Arnold, Robert, Bevan-Jones, W Richard, Borchert, Robin J, Cope, Thomas E, Fryer, Tim D, Hong, Young T, Jones, P Simon, Mak, Elijah, O'Brien, John T, Passamonti, Luca, Rowe, James B, Sami, Saber, Su, Li, Surendranathan, Ajenthan, Vázquez Rodríguez, Patricia, Williamson, David   +17 more
core   +1 more source

Assessing midbrain neuromelanin and its relationship to reward learning in anorexia nervosa: Stage 1 of a registered report

Brain and Behavior
Introduction Anorexia nervosa (AN) is a debilitating and potentially chronic eating disorder, characterized by low hedonic drive toward food, which has been linked with perturbations in both reward processing and dopaminergic activity.
Stuart B. Murray, Joel P. Diaz‐Fong, Vienna W. T. Mak, Jamie D. Feusner   +3 more
doaj   +1 more source

Structural anomaly in the reticular formation in narcolepsy type 1, suggesting lower levels of neuromelanin

NeuroImage: Clinical, 2019
The aim of this study was to investigate structural changes in the brain stem of adolescents with narcolepsy, a disorder characterized by excessive daytime sleepiness, fragmented night-time sleep, and cataplexy.
Natasha Morales Drissi, Marcel Warntjes, Alexander Wessén, Attila Szakacs, Niklas Darin, Tove Hallböök, Anne-Marie Landtblom, Helena Gauffin, Maria Engström   +8 more
doaj   +1 more source

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice [PDF]

, 2010
BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Auburger, Georg, Bockhart, Vanessa, Bonin, Michael, Calabresi, Paolo, Double, Kay L., Fernández-Ruiz, Javier, García-Arencibia, Moisés, Gerlach, Manfred, Gispert, Suzana, Kurz, Alexander, Lastres-Becker, Isabel, Liss, Birgit, Lüddens, Hartmut, Nuber, Silke, Schlaudraff, Falk, Tantucci, Michela, Tozzi, Alessandro, Wüllner, Ullrich   +17 more
core   +1 more source

Quantitative Assessment of Visible Nigrosome‐1 in Patients with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The nigrosome‐1 (N1) sign on susceptibility‐weighted imaging (SWI) typically disappears in Parkinson's disease (PD), though some patients can show uni−/bilaterally preserved N1. Objective Investigating whether visible nigrosomes in PD patients differ from those of healthy subjects (HC). Methods Forty‐eight PD and 35 HC underwent 3 T‐
Maria Eugenia Caligiuri, Ilaria Chimento, Marida De Maria, Emma Biondetti, Jolanda Buonocore, Valerio Riccardo Aquila, Maria Celeste Bonacci, Emanuele Tinelli, Umberto Sabatini, Aldo Quattrone, Andrea Quattrone   +10 more
wiley   +1 more source