Results 31 to 40 of about 8,760 (227)
npj Parkinson's Disease, 2022 MRI was suggested as a promising method for the diagnosis and assessment of Parkinson’s Disease (PD). We aimed to assess the sensitivity of neuromelanin-MRI and T2* with radiomics analysis for detecting PD, identifying individuals at risk, and evaluating
Dafna Ben Bashat +11 more
doaj +1 more source
Automated Neuromelanin Imaging as a Diagnostic Biomarker for Parkinson's Disease [PDF]
, 2015 Published onlineWe aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method of the SNc and locus coeruleus (LC) volumes based on neuromelanin (NM)-sensitive MRI (NM-MRI) in patients with idiopathic (iPD) and ...
Adler +46 more
core +3 more sources
Cells, 2019 Parkinson’s disease is associated with an increased risk of melanoma (and vice versa). Several hypotheses underline this link, such as pathways affecting both melanin and neuromelanin.
Dieter Leupold +9 more
doaj +1 more source
Bright light exposure reduces TH-positive dopamine neurons: Implications of light pollution in Parkinson\u27s disease epidemiology [PDF]
, 2013 This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra.
Aliosi, Gabriella +14 more
core +2 more sources
Antioxidants, 2023 Investigations of the effect of antioxidants on idiopathic Parkinson’s disease have been unsuccessful because the preclinical models used to propose these clinical studies do not accurately represent the neurodegenerative process of the disease ...
Juan Segura-Aguilar, Bengt Mannervik
doaj +1 more source
Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology. [PDF]
, 2013 This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra.
Allison W. Willis, +13 more
core +1 more source
Frontiers in Neuroscience, 2022 ObjectiveNeuromelanin-sensitive magnetic resonance imaging (NM-MRI) technique was used to detect the changes of the locus coeruleus (LC) signals in Alzheimer’s disease patients (AD), and to analyze its correlation with cognitive function.Materials and ...
Meng Li +10 more
doaj +1 more source
Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease [PDF]
, 2017 open4siAging is the biggest risk factor for developing many neurodegenerative disorders, including idiopathic Parkinson's disease (PD). PD is still an incurable disorder and the available medications are mainly directed to the treatment of symptoms in ...
core +1 more source
Encapsulation of a reactive core in neuromelanin [PDF]
Proceedings of the National Academy of Sciences, 2006 Melanin pigments are found widely in animals and plants (1). Melanin's most conspicuous presence is on the surface of the body, where it serves to protect underlying tissues from harmful UV radiation and to camouflage the organism from enemies. Two chemically distinct types of melanin pigments are produced in the melanocytes of mammals and birds: the ...
openaire +2 more sources
Dopamine Oxidation and Autophagy
Parkinson's Disease, 2012 The molecular mechanisms involved in the neurodegenerative process of Parkinson's disease remain unclear. Currently, there is a general agreement that mitochondrial dysfunction, α-synuclein aggregation, oxidative stress, neuroinflammation, and impaired ...
Patricia Muñoz +3 more
doaj +1 more source