Results 121 to 130 of about 71,981 (295)

Peripheral Mononuclear Cell Mitochondrial Function Associates with T‐Cell Cytokines in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is the most common neurodegenerative movement disorder and one of the world's fastest‐growing neurological diseases. Although the exact causes of PD are unknown, mitochondrial dysfunction and inflammation may have significant roles in disease progression.
Fatima Afaar, Priscilla Youssef, Jasmin Galper, Michelle Chua, Glenda M. Halliday, Simon J.G. Lewis, Nicolas Dzamko   +6 more
wiley   +1 more source

Reduction of alpha-synuclein oligomers in preclinical models of Parkinson’s disease by electrical stimulation in vitro and deep brain stimulation in vivo

Brain Stimulation
Background: Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD).
Eun Jung Lee, David Hernán Aguirre-Padilla, Anton Fomenko, Grishma Pawar, Minesh Kapadia, Jimmy George, Andres M. Lozano, Clement Hamani, Lorraine V. Kalia, Suneil K. Kalia   +9 more
doaj  

Decrease of Glutamate Decarboxylase Activity in Substantia Nigra and Caudoputamen following Transient Hyperglycemic Ischemia in the Rat

, 1989
Jaroslava Folbergrová, Maj‐Lis Smith, K Inamura, Bo K. Siesjö   +3 more
openalex   +1 more source

Microstructural Changes in the Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disorders

Movement Disorders, EarlyView.
Abstract Background Excessive daytime sleepiness (EDS) is a disabling symptom of Lewy body disorders (LBD). The hypothalamus is a key sleep–wake regulator and is involved in Lewy pathology, but its contribution to EDS in LBD remains unclear. Objectives To use diffusion‐weighted magnetic resonance imaging (MRI) to detect hypothalamic microstructure and ...
Jesse S. Cohen, Hamsanandini Radhakrishnan, Christopher A. Olm, Sandhitsu R. Das, Philip A. Cook, David A. Wolk, Daniel Weintraub, David J. Irwin, Corey T. McMillan   +8 more
wiley   +1 more source

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

, 1987
M.G. Lacey, Nicola Biagio Mercuri, R. Alan North   +2 more
openalex   +2 more sources

Glial Cell Line‐Derived Neurotrophic Growth Factor Inhibits Apoptotic Death of Postnatal Substantia Nigra Dopamine Neurons in Primary Culture [PDF]

, 1998
Robert E. Burke, Megan Antonelli, David Sulzer   +2 more
openalex   +1 more source

Disease‐Modifying Trials in Treated Parkinson's Disease: “Stable Treated” Does Not Equate with Biological Stability

Movement Disorders, EarlyView.
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian, A. Jon Stoessl, Anthony E. Lang   +2 more
wiley   +1 more source

Study on transcranial sonography in patients with idiopathic rapid eye movement sleep behavior disorder

Chinese Journal of Contemporary Neurology and Neurosurgery, 2016
Objective To investigate the changes of transcranial sonography (TCS) in patients with rapid eye movement sleep behavior disorder (RBD).  Methods Fifteen patients fulfilled the diagnostic criteria of RBD according to International Classification of ...
Xu-dong LI, Shuang XUE, Chun-lei HOU, Shu-hong JIA, Ya-nan QIAO, Zhi ZHOU, Kun WEI, Wen-jing ZHENG, Pei RONG, Jin-song JIAO   +9 more
doaj  

Substantia Nigra Iron Deposition in Lewy Body Disease: A Magnetic Resonance Imaging and Neuropathology Study

Movement Disorders, EarlyView.
Abstract Objective To compare iron deposition in the substantia nigra (SN) as measured with quantitative susceptibility mapping (QSM) on antemortem magnetic resonance imaging (MRI) between individuals with and without Lewy‐related pathology at autopsy. Methods We performed a retrospective cohort study including 54 participants who underwent autopsy and
Patricia Diaz‐Galvan, Scott A. Przybelski, Timothy G. Lesnick, Melissa E. Murray, Aivi Nguyen, Ross R. Reichard, Dennis W. Dickson, Daisuke Ono, Matthew L. Senjem, Christopher G. Schwarz, Jeffrey Gunter, Val Lowe, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff‐Radford, Vijay K. Ramanan, David Jones, Hugo Botha, Erik K. St. Louis, David Knopman, Gregory S. Day, Neill Graff‐Radford, Walter Kremers, Ronald C. Petersen, Clifford R. Jack Jr, Tanis J. Ferman, Bradley F. Boeve, Kejal Kantarci   +28 more
wiley   +1 more source

Autoradiographic localization of neuroleptic and dopamine receptors in the caudate-putamen and substantia nigra: Effects of lesions

, 1980
L. Charles Murrin, Karen Gale, Michael J. Kuhar   +2 more
openalex   +1 more source