Results 131 to 140 of about 129,849 (338)

Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo‐hMSCs) may reduce neuroinflammation and improve motor symptoms. Objectives To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo‐hMSCs in improving motor symptoms in patients
Mya C. Schiess, Jessika Suescun, Juan D. Martinez‐Lemus, Charles Green, Tia S. Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B. Satani, Jerome G. Saltarrelli, Christopher Adams, Marie‐Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M. Rodarte, Sean I. Savitz, Timothy M. Ellmore   +15 more
wiley   +1 more source

A New Phenotype–Genotype Correlation for FIG4 and Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki   +4 more
wiley   +1 more source

Patient‐Derived Neurons Exhibit α‐Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein–Associated Neurodegeneration

Movement Disorders, EarlyView.
Abstract Background Mitochondrial membrane protein–associated neurodegeneration (MPAN) from the neurodegeneration with brain iron accumulation (NBIA) family is a rare neurodegenerative disease marked by α‐synuclein aggregation, brain iron accumulation, and midbrain dopaminergic neuron degeneration.
Leonie M. Heger, Leonie Kertess, Clara Kaufhold, Francesco Gubinelli, Aida Cardona‐Alberich, Gamze Özata, Stephan A. Müller, Sarah K. Tschirner, Oliver Stehling, Martina Schifferer, Camille Peron, Valeria Tiranti, Roland Lill, Arcangela Iuso, Luigi Zecca, Michael Strupp, Wolfgang Oertel, Stefan F. Lichtenthaler, Lena F. Burbulla   +18 more
wiley   +1 more source

INHIBITION OF THALAMIC AND HYPOTHALAMIC SOMATOSENSORY EVOKED POTENTIALS BY STIMULATION OF SUBSTANTIA NIGRA AND ITS MODIFICATION BY MORPHINE AND METHOTRIMEPRAZINE (LEVOMEPROMAZINE)

, 1976
Hiroshi Kuromi, Masamichi Satoh, Hiroshi Takagi   +2 more
openalex   +1 more source

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease [PDF]

, 1992
E. Sofić, Klaus W. Lange, K. A. Jellinger, P. Riederer   +3 more
openalex   +1 more source

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α‐synuclein (aSyn), are linked to rare familial forms of PD. Objective Our goal was to assess the clinical presentation and the biological effects of a novel K58N ...
Mohammed Al‐Azzani, Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre, Michael Zech, Kevin Sicking, Alain Ibáñez de Opakua, Vidyashree Jayanthi, Leslie Amaral, Aishwarya Agarwal, Aswathy Chandran, Susana R. Chaves, Juliane Winkelmann, Claudia Trenkwalder, Maike Schwager, Silke Pauli, Ulf Dettmer, Claudio O. Fernández, Janin Lautenschläger, Markus Zweckstetter, Ruben Fernandez‐Busnadiego, Brit Mollenhauer, Tiago Fleming Outeiro   +24 more
wiley   +1 more source

The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2019
Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress.
Toraj Mohammad zamani, Ahmadreza Movahedi, Elahe Arab ameri   +2 more
doaj  

High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons

Cells
Pacemaking activity in substantia nigra dopaminergic neurons is generated by the coordinated activity of a variety of distinct somatodendritic voltage- and calcium-gated ion channels. We investigated whether these functional interactions could arise from
Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Pouey   +6 more
doaj   +1 more source

HISTOLOGICAL STUDIES ON THE INTRANUCLEAR INCLUSIONS OF THE MELANIN-PIGMENTED NERVE CELLS IN THE SUBSTANTIA NIGRA AND THE NUCLEUS LOCI CAERULEI

, 1970
Shigemi Anraku, CHISHIN MIURA, Hironori Mori, Toshiaki Fukutomi   +3 more
openalex   +2 more sources

An Unusual Motor OFF in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Shreyashi Jha, Mandar S. Jog
wiley   +1 more source