Results 151 to 160 of about 129,849 (338)
Biallelic Variants in SLC27A3 Cause a Complex Form of Neurodegeneration with Brain Iron Accumulation
Movement Disorders, EarlyView.Abstract Background Complex lipid metabolism is one of the main biological pathways disrupted in neurodegeneration with brain iron accumulation (NBIA). SLC27A3 gene encodes for the very long‐chain acyl‐CoA synthetase 3, an acyl‐CoA ligase that activates long and very long‐chain fatty acids.
Lorena Travaglini +8 more
wiley +1 more source
Histochemical study on catecholamine of substantia nigra of the brain
, 1977 Yoshihumi Yokoyama
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Altered Dopamine Metabolism and Response to Treatment with Levodopa/Carbidopa in MCT8 Deficiency
Movement Disorders, EarlyView.Abstract Background Allan‐Herndon‐Dudley syndrome (AHDS)/monocarboxylate transporter 8 (MCT8) deficiency is a rare X‐linked encephalopathy caused by SLC16A2 variants, impairing thyroid hormone (TH) transport into the brain. This leads to early central nervous system (CNS) TH deficiency, affecting brain maturation.
Fabio Bruschi +12 more
wiley +1 more source
D1 agonist-induced excitation of substantia nigra pars reticulata neurons: mediation by D1 receptors on striatonigral terminals via a pertussis toxin-sensitive coupling pathway [PDF]
, 1994 LP Martin, BL Waszczak
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Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, EarlyView.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
Vessel segmentation for χ$$ \chi $$‐separation in quantitative susceptibility mapping
Magnetic Resonance in Medicine, EarlyView.Abstract Purpose χ$$ \chi $$‐separation is an advanced quantitative susceptibility mapping (QSM) method that is designed to generate paramagnetic (χpara$$ {\chi}_{para} $$) and diamagnetic (|χdia|$$ \mid {\chi}_{dia}\mid $$) susceptibility maps, reflecting the distribution of iron and myelin in the brain.
Taechang Kim +7 more
wiley +1 more source
Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. [PDF]
, 1993 Theo Hagg, Silvio Varon
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