Results 161 to 170 of about 132,532 (337)

Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X‐Band EPR Study

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Paramagnetic ions are distributed throughout the human brain. The increased accumulation of these metals, such as iron and copper, can induce cellular death and the development of neurological diseases. Electron Paramagnetic Resonance (EPR) is a spectroscopic technique capable of detecting these ions in a given biological sample ...
André Avanzine, José Henrique Monteiro de Azevedo, Martina Huber, Fábio Seiji Otsuka, Maria Concepción García Otaduy, Roberta Diehl Rodriguez, Carlos Ernesto Garrido Salmon   +6 more
wiley   +1 more source

Substantia Nigra

, 2009
Jeremy Jones, Francis Deng, Roney Sam
openaire   +2 more sources

NF-κB/c-Rel DNA-binding is reduced in substantia nigra and peripheral blood mononuclear cells of Parkinson's disease patients

, 2023
Vanessa Porrini, Andrea Pilotto, Marika Vezzoli, Annamaria Lanzillotta, Michele Mario Gennari, Sonia Bonacina, Antonella Alberici, Rosanna Turrone, Arianna Bellucci, Angelo Antonini, Alessandro Padovani, Marina Pizzi   +11 more
openalex   +1 more source

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani, Fei Fang, Scott E. Counts, Liangliang Sun   +3 more
wiley   +1 more source

The Hyperpolarization-Activated Current Determines Synaptic Excitability, Calcium Activity and Specific Viability of Substantia Nigra Dopaminergic Neurons [PDF]

, 2017
Carmen Carbone, Alessia Costa, Gustavo Provensi, Guido Mannaioni, Alessio Masi   +4 more
openalex   +1 more source

Unilateral Magnetic Resonance‐Guided Focused Ultrasound (MRgFUS) Pallidothalamic Tractotomy in Parkinson's Disease: Promising Results But Uncertain Target

Movement Disorders, EarlyView.
Mickael Aubignat
wiley   +1 more source

Probing Early α‐Synuclein Oligomers: Insights Into Aggregation Pathways of NACore and preNAC Segments Probed by Trapped Ion‐Mobility Mass Spectrometry and Fluorescence Spectroscopy

PROTEOMICS, EarlyView.
ABSTRACT Misfolding and aggregation of α‐Synuclein (α‐Syn) play a central role in Parkinson's disease (PD), with oligomeric intermediates implicated as key toxic species. Here, we investigate the aggregation of two α‐Syn segments, the NACore (68GAVVTGVTAVA78, WT‐PD1) and the preNAC region (47GVVHGVATVA56, WT‐PD2), using high‐resolution trapped ion ...
Agathe Depraz Depland, Stephanie Mikromanolis, Iuliia Stroganova, Anouk M. Rijs   +3 more
wiley   +1 more source

Multi‐Channel Neural Interface for Neural Recording and Neuromodulation

Small Methods, EarlyView.
This review highlights recent advances in multi‐channel neural interface technologies, covering both high‐resolution electrophysiological recording systems and multifunctional platforms with integrated capabilities. It also discusses innovations in structure and materials for reduced invasiveness, state‐of‐the‐art data analysis, including machine ...
Eunmin Kim, Won Gi Chung, Enji Kim, Myoungjae Oh, Joonho Paek, Taekyeong Lee, Dayeon Kim, Seung Hyun An, Sumin Kim, Jang‐Ung Park   +9 more
wiley   +1 more source

Secondary Degeneration of the Substantia Nigra and Corticospinal Tract after Hemorrhagic Middle Cerebral Artery Infarction: Diffusion-weighted MR Findings

, 2002
Toshibumi Kinoshita, Toshio Moritani, David A. Shrier, Henry Z. Wang, Akio Hiwatashi, Yuji Numaguchi, Per‐Lennart Westesson   +6 more
openalex   +2 more sources

Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models

VIEW, EarlyView.
Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley   +1 more source