Results 241 to 250 of about 76,030 (307)

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, Volume 36, Issue 2, March 2026.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

Multi-neuromeric origin of tyrosine hydroxylase-positive neurons within the substantia nigra and ventral tegmental area. [PDF]

Front Neuroanat
Ferran JL, Lucero-Arteaga F, Ayad A, Kutsenko Y, Alonso A, Do-Couto BR, García-Cabezas MÁ, Tseng KY.   +7 more
europepmc   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease. [PDF]

Exp Neurol
Miranda NC, Aquino YC, Macedo TO, Oliveira LM, Albernaz-Mariano KA, Munhoz CD, Ramirez JM, Moreira TS, Takakura AC.   +8 more
europepmc   +1 more source

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan, Maija Corey, Alicia Gibbons, Mahati Rayadurgam, Neha Reddy, Pavithra Ramesh, Sonia Sharma   +6 more
wiley   +1 more source

Spatial variations and precise location of substantia nigra hyperechogenicity in Parkinson's disease using TCS-MR fusion imaging. [PDF]

NPJ Parkinsons Dis
Hou C, Zhang W, Li HB, Li S, Nie F, Wang XM, He W.   +6 more
europepmc   +1 more source

Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra. [PDF]

J Neurochem
Fitzgerald JC, Sun Y, Reinecke F, Bauer E, Garaschuk O, Kahle PJ, Pfeiffer F.   +6 more
europepmc   +1 more source

Reply: “Leigh Syndrome Due to the Variant c.1019T>C in COX15”

Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 847-848, March 2026.
Haya S. AlFaris, Sangeetha Yoganathan, Marcus N. Callister, Liali Aljouda, Vivek Pai, Pradeep Krishnan, Andrea LeBlanc Miller, Christos Ganos, Carolina Gorodetsky   +8 more
wiley   +1 more source

Efficacy and safety assessment of homotopical transplantation of iPSCs-derived midbrain organoids into the substantia nigra of Parkinsonian rats. [PDF]

Bioeng Transl Med
Zheng X, Chen J, Huang Z, Zhang Y, Zhou L.   +4 more
europepmc   +1 more source

Beyond Pathology: α‐Synuclein Homeostasis and Three Principles to Guide Research

Movement Disorders Clinical Practice, Volume 13, Issue 3, Page 668-672, March 2026.
Alberto J. Espay, Andrew J. Lees
wiley   +1 more source