Results 251 to 260 of about 123,845 (338)

Advancements in understanding substantia nigra hyperechogenicity via transcranial sonography in Parkinson's disease and its clinical implications. [PDF]

Front Neurol
Zhang YY, Jiang XH, Zhu PP, Zhuo WY, Liu LB.   +4 more
europepmc   +1 more source

Nutritionally Responsive PMv DAT Neurons Are Dynamically Regulated During Pubertal Transition

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
The ventral premammillary nucleus of the hypothalamus plays an essential role in the metabolic control of reproduction. Puberty brings large changes to a subpopulation of PMvLepRb cells expressing the dopamine transporter (PMvDAT). DAT gene expression is higher in prepubertal females than in adults and is regulated by leptin in prepubertal females ...
Cristina Sáenz de Miera, Nicole Bellefontaine, Marina A. Silveira, Chelsea N. Fortin, Thais T. Zampieri, Jose Donato Jr, Kevin W. Williams, Cristiano Mendes‐da‐Silva, Laura Heikkinen, Christian Broberger, Renata Frazao, Carol F. Elias   +11 more
wiley   +1 more source

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Advanced Science, Volume 12, Issue 25, July 3, 2025.
Utilizing a stereotaxic injection mouse model and a novel mathematical approach, this study uncovers key subnetworks that drive pathological α‐synuclein (α‐Syn) progression in Parkinson's disease (PD). Remarkably, just 2% of the strongest connections in the connectome are sufficient to predict its spread.
Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng   +16 more
wiley   +1 more source

Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta. [PDF]

Addict Neurosci
Conrad WS, Oriol L, Kollman GJ, Faget L, Hnasko TS.   +4 more
europepmc   +1 more source

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays, Volume 47, Issue 7, July 2025.
Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley   +1 more source

A deep cellular atlas of the human ventral substantia nigra in Parkinson’s identifies a genetic and molecular overlap with Type 2 Diabetes

Volpato V, Menassa DA, Sheshadri P, Giussani S, Rokicki M, Cardo LF, Bafaloukou M, Schalkamp A, Zaremba A, Monzón-Sandoval J, Vinh N, Morgan J, Hu MT, Miners S, Wade-Martins R, Sandor C, Parkkinen L, Webber C.   +17 more
europepmc   +1 more source

The cerebellum directly modulates the substantia nigra dopaminergic activity. [PDF]

Nat Neurosci
Washburn S, Oñate M, Yoshida J, Vera J, Bhuvanasundaram R, Khatami L, Nadim F, Khodakhah K.   +7 more
europepmc   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Immunohistochemical Study of Human Mitochondrial Ferritin in the Substantia Nigra Following Subarachnoid Hemorrhage. [PDF]

Acta Histochem Cytochem
Takahata S, Kato T, Yanagisawa D, Tsubaki H, Hafiz Abu Bakar Z, Mukaisho KI, Itoh Y, Tooyama I.   +7 more
europepmc   +1 more source

GATA Transcription Factors: A Cross‐Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Alpha‐synuclein (α‐syn), a 140 amino acid protein, is abundantly expressed in the central nervous system (CNS) and in the erythrocytes, playing a pivotal role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies.
Francesco Bellomi, Claudia Caturano, Viola Velardi, Romina Mancinelli, Simone Carotti, Giorgio Vivacqua, Francesca Arciprete, Maria Zingariello   +7 more
wiley   +1 more source