Results 251 to 260 of about 132,532 (337)

Age‐Related Alterations in Hippocampal Microstructure Quantified Using High‐Gradient Diffusion MRI (dMRI) in an Unfolded Hippocampal Space

Aging Cell, Volume 25, Issue 1, January 2026.
Using high‐gradient diffusion MRI with the SANDI model and HippUnfold for fine‐scale analysis, we detected localized hippocampal aging changes beyond volumetric/thickness reductions. Subiculum and dentate gyrus exhibit significantly reduced soma density/size and increased extracellular space, highlighting subtle microstructural alterations critical for
Yixin Ma, Hansol Lee, Kwok‐Shing Chan, Laleh Eskandarian, Kyla Gaudet, Qiyuan Tian, Aneri Bhatt, Julianna Gerold, Andrew W. Russo, David H. Salat, Eric C. Klawiter, Susie Y. Huang, Hong‐Hsi Lee   +12 more
wiley   +1 more source

Expression of Genes Encoding Receptors for Classical Neurotransmitters, Neuropeptides and Hormones in the Substantia Nigra, Especially in Dopaminergic Neurons, in Intact Mice and Mouse Models of Parkinson's Disease. [PDF]

Cells
Troshev D, Pavlova E, Bogdanov V, Ugrumov M.   +3 more
europepmc   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Autologous Peripheral Nerve Tissue Grafts Implanted into the Nucleus Basalis of Meynert and Substantia Nigra at the Time of Bilateral Deep Brain Stimulation in Parkinson Disease: A Report of 2 Cases. [PDF]

Neurosurg Pract
Daly SR, Quintero JE, Koehl L, Wallace E, Guduru Z, Gurwell JA, Hines T, Hixson J, Hulou S, Slevin JT, Schmitt FA, Gerhardt GA, van Horne CG.   +12 more
europepmc   +1 more source

Comparison of automated and manual approaches for microglial quantification and classification: A focus on the HALO digital pathology platform

Brain Pathology, Volume 36, Issue 1, January 2026.
The Halo microglial activation module has not been formally validated in the literature. Comparison of this module with established methods revealed varied performance dependent on tissue thickness, highlighting the need for care to be taken when optimising image analysis parameters. Abstract Phenotypic changes in microglia have been linked to multiple
Laura M. Carr, Bianca Guglietti, Ing Chee Wee, Ian F. Musgrave, Sanam Mustafa, Frances Corrigan, Lyndsey E. Collins‐Praino   +6 more
wiley   +1 more source

The effect of cannabinoid type Ⅱ receptor on the excitability of substantia nigra dopaminergic neurons. [PDF]

Front Pharmacol
Zhao S, Liu S, Gong Y, Ma Z.
europepmc   +1 more source

Striatal Nitric Oxide Activity Better Predicts Motor Disability Than Proto‐Oncogenes

European Journal of Neuroscience, Volume 63, Issue 1, January 2026.
The figure summarizes the experimental design in which mice received a single intraperitoneal injection of saline, haloperidol, metoclopramide, or L‐NOARG at different doses. Extrapyramidal (EPS) side effects were assessed using the catalepsy test and the Rota‐rod test.
Sonia Guerrero Prieto, Victor Ricardo C. Torres da Silva, Maria Camila Almeida, Marcela B. Echeverry   +3 more
wiley   +1 more source

High-resolution mapping of substantia nigra in Parkinson's disease using 7 tesla magnetic resonance imaging. [PDF]

NPJ Parkinsons Dis
Madelung CF, Løkkegaard A, Fuglsang SA, Marques MM, Boer VO, Madsen KH, Hejl AM, Meder D, Siebner HR.   +8 more
europepmc   +1 more source

Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPP+‐Induced Parkinson's Disease Model via PPARγ Activation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective and anti‐inflammatory potential of Aesculus hippocastanum (horse chestnut extract, HCE) in an in vitro model of PD.
Sarah Adriana Scuderi, Alessio Ardizzone, Giovanna Casili, Deborah Mannino, Antonio Catalfamo, Marika Lanza, Emanuela Esposito   +6 more
wiley   +1 more source

Multi-neuromeric origin of tyrosine hydroxylase-positive neurons within the substantia nigra and ventral tegmental area. [PDF]

Front Neuroanat
Ferran JL, Lucero-Arteaga F, Ayad A, Kutsenko Y, Alonso A, Do-Couto BR, García-Cabezas MÁ, Tseng KY.   +7 more
europepmc   +1 more source