Results 261 to 270 of about 123,845 (338)

Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains. [PDF]

NPJ Parkinsons Dis
Ermini F, Low VF, Song JJ, Tan AYS, Faull RLM, Dragunow M, Curtis MA, Dominy SS.   +7 more
europepmc   +1 more source

Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy

Glia, Volume 73, Issue 7, Page 1502-1519, July 2025.
Main Points During ageing, the complexity of astrocyte morphology peaks at adulthood then declines. In Tau22 transgenic mice, tau accumulates in astrocytes with age. Tauopathy is associated with simpler initial morphology followed by the appearance of a cluster of complex cells at advanced stage.
Emma Augustin, Tatiana Vinasco‐Sandoval, Miriam Riquelme‐Perez, Damien Plassard, Mylène Gaudin, Gwenaëlle Aurégan, Julien Mitja, Sueva Bernier, Charlène Joséphine, Fanny Petit, Caroline Jan, Anne‐Sophie Hérard, Marie‐Claude Gaillard, Agathe Launay, Emilie Faivre, Luc Buée, Anne‐Laurence Boutillier, David Blum, Alexis‐Pierre Bemelmans, Gilles Bonvento, Karine Cambon   +20 more
wiley   +1 more source

Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model. [PDF]

Zool Res
Ma XZ, Jia GR, Li MY, Zhang SH, Wang ZX, Song N, Liu YJ, Xie JX.   +7 more
europepmc   +1 more source

Neuropathological Correlates of Volume and Shape of Deep Gray Matter Structures in Community‐Based Older Adults

Human Brain Mapping, Volume 46, Issue 10, July 2025.
The present study revealed the independent effects of age‐related neuropathologies on both the volume and shape of multiple deep gray matter structures by combining ex vivo MRI and detailed pathology data in a large number of community‐based older adults. Mixed pathologies are very common and the present study disentangles their effects.
Khalid Saifullah, Nazanin Makkinejad, Md Tahmid Yasar, Arnold M. Evia, Sue E. Leurgans, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +7 more
wiley   +1 more source

Bibliometric analysis of global research trends in magnetic resonance imaging studies of substantia nigra in Parkinson's disease (2001-2024). [PDF]

Front Aging Neurosci
Jiang M, Deng X, Qiu Z, Li J, Song Z, Chen X, Chen R, Huang X, Cui X, Fu Y.   +9 more
europepmc   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source

Diagnostic utility of 7T neuromelanin imaging of the substantia nigra in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Lakhani DA, Zhou X, Tao S, Patel V, Wen S, Okromelidze L, Greco E, Lin C, Westerhold EM, Straub S, Wszolek ZK, Tipton PW, Uitti RJ, Grewal SS, Middlebrooks EH.   +14 more
europepmc   +1 more source

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Janus H. Magnussen
wiley   +1 more source

Automatic substantia nigra segmentation with Swin-Unet in susceptibility- and T2-weighted imaging: application to Parkinson disease diagnosis. [PDF]

Quant Imaging Med Surg
Wang T, Wang Y, Zhu H, Liu Z, Chen YC, Wang L, Duan S, Yin X, Jiang L.   +8 more
europepmc   +1 more source