Results 261 to 270 of about 71,981 (295)
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Evidence for autapses in the substantia nigra
Brain Research, 1980Intracellular recording and intracellular HRP staining were employed to trace the recurrent terminal plexus of cat substantia nigra pars reticulata neurons. Autaptic neurons were labeled. The axon of an autaptic neuron was found to emit a recurrent collateral which distributed 'en passage' and terminal boutons contacting dendrites of the parent cell ...
Athanasios B. Karabelas +1 more
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The role of GABA in the substantia nigra
Nature, 1978STRIATONIGRAL GABAergic fibres are widely believed to exert a tonic inhibitory influence on the dopamine (DA)-containing cells of the substantia nigra (SN), and contraversive and ipsiversive circling behaviour can be explained in terms of a greater or lesser activity of the dopaminergic neurones, respectively1,2. However, the blockade of γ-aminobutyric
T. A. James, M. S. Starr
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Dendritic release of dopamine in the substantia nigra [PDF]
Nature, 1981 Dopamine can be released in the substantia nigra for the dendrites of nigrostriatal dopaminergic neurones, to be involved there in the self-regulation of the dopaminergic cells, to control the release of neurotransmitters from nigral afferent fibres and to influence the activity of nigral non-dopaminergic cells.
André Chéramy +2 more
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Synapses in the rat substantia nigra
Tissue and Cell, 1971The composition and organization of the input to the rat substantia nigra were studied with the electron microscope. Four distinct types of synaptic boutons were described. The first contained small (381 A), clear synaptic vesicles. The second type contained the small, clear vesicles and several large, dense-core vesicles.
Robert L. Gulley, Morris Smithberg
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Neuromelanin of the Human Substantia Nigra: An Update
Neurotoxicity Research, 2013Dopaminergic neurons of the substantia nigra selectively degenerate over the course of Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain, accumulating the dark pigment neuromelanin over a lifetime. The massive presence of neuromelanin in these brain areas has long been suspected as a key factor involved in the ...
Zucca FA +6 more
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The substantia nigra of the rat: A golgi study
Journal of Comparative Neurology, 1977AbstractThree variants of the Golgi method were employed to examine the cell types, their dendritic fields and organization and azonal trajectories within the substantia nigra of albino and hooded rats. In both sagittal and coronal sections, large, medium and small neurons were classified on the basis of soma size, extent of dendritic fields and ...
Philip M. Groves +2 more
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Uptake of Acetylcholinesterase by Neurons in the Substantia Nigra
European Journal of Neuroscience, 1995AbstractIt is known that acetylcholinesterase is secreted by the dopaminergic neurons of the substantia nigra and has a subsequent action independent of cholinergic transmission. Although non‐cholinergic actions of this protein have been demonstrated, the subsequent fate of acetylcholinesterase is unknown.
B. G. M. Dickie +3 more
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GABAergic synaptic interactions in the substantia nigra
Brain Research, 1993The substantia nigra receives a strong GABAergic input from the ipsilateral striatum and globus pallidus. Nigral GABAergic synaptic interactions have been described in the pars compacta (SNC) and pars reticulata (SNR) but not in the pars lateralis (SNL). The SNR and particularly the SNL are the nodal points of the GABAergic nigrotectal pathway.
B. A. Flumerfelt +2 more
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Death in the substantia nigra: a motor tragedy
Expert Review of Neurotherapeutics, 2007It is well known that the death of dopaminergic neurons of the substantia nigra pars compacta (SNc) is the pathological hallmark of Parkinson's disease (PD), the second most common and disabling condition in the expanding elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and ...
ESPOSITO E +2 more
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Hyperechogenicity of the Substantia Nigra in Parkinson's Disease
Journal of Neuroimaging, 2007ABSTRACTSubstantia nigra (SN) was assessed by transcranial sonography (TCS) in 47 Parkinson's disease (PD) patients and in 39 healthy volunteers. A semiquantitative echogenicity scale was created with arbitrary values ranging from 1 to 5, zones with grade ≥3 and larger than 0.19 cm2 were recorded as hyperechogenic SN.
David Školoudík +3 more
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