Results 1 to 10 of about 660,873 (335)
Structural basis of SIRT7 nucleosome engagement and substrate specificity [PDF]
Nature CommunicationsChromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity ...
Carlos Moreno-Yruela +6 more
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Substrate Specificity of Biofilms Proximate to Historic Shipwrecks [PDF]
Microorganisms, 2023 The number of built structures on the seabed, such as shipwrecks, energy platforms, and pipelines, is increasing in coastal and offshore regions. These structures, typically composed of steel or wood, are substrates for microbial attachment and biofilm ...
Rachel L. Mugge +2 more
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Discovery and substrate specificity engineering of nucleotide halogenases [PDF]
Nature CommunicationsC2′-halogenation has been recognized as an essential modification to enhance the drug-like properties of nucleotide analogs. The direct C2ʹ-halogenation of the nucleotide 2′-deoxyadenosine-5′-monophosphate (dAMP) has recently been achieved using the Fe ...
Jie Ni +4 more
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Structural Analysis and Substrate Specificity of D-Carbamoylase from Pseudomonas [PDF]
BioTechThe synthesis of enantiomeric forms of D-amino acids can be achieved by a two-step “hydantoinase process” based on the sequential catalysis of substrates by specific enzymes, D-carbamoylase and D-hydantoinase. Here, we describe the structural features of
Marina Paronyan +9 more
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Activation and substrate specificity of the human P4-ATPase ATP8B1 [PDF]
Nature Communications, 2023 Asymmetric distribution of phospholipids in eukaryotic membranes is essential for cell integrity, signaling pathways, and vesicular trafficking. P4-ATPases, also known as flippases, participate in creating and maintaining this asymmetry through active ...
Thibaud Dieudonné +9 more
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Substrate specificity mapping of fungal CAZy AA3_2 oxidoreductases [PDF]
Biotechnology for Biofuels and BioproductsBackground Oxidative enzymes targeting lignocellulosic substrates are presently classified into various auxiliary activity (AA) families within the carbohydrate-active enzyme (CAZy) database.
Hongbo Zhao +9 more
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Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
Viruses, 2021 The ongoing COVID-19 pandemic exemplifies the general need to better understand viral infections. The positive single-strand RNA genome of its causative agent, the SARS coronavirus 2 (SARS-CoV-2), encodes all viral enzymes.
Roberto Benoni +5 more
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Profiling of substrate specificity of SARS-CoV 3CL. [PDF]
PLoS ONE, 2010 BACKGROUND: The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-coronavirus is required for autoprocessing of the polyprotein, and is a potential target for treating coronaviral infection.
Chi-Pang Chuck +5 more
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Probing ADAMTS13 substrate specificity using phage display. [PDF]
PLoS ONE, 2015 Von Willebrand factor (VWF) is a large, multimeric protein that regulates hemostasis by tethering platelets to the subendothelial matrix at sites of vascular damage.
Karl C Desch +7 more
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Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. [PDF]
PLoS ONE, 2016 In the present studies, we focused on substrate specificity of tocopherol cyclase, the key enzyme in the biosynthesis of the tocopherols and plastochromanol-8, the main plant lipid antioxidants, with special emphasis on the preference for tocopherols and
Jolanta Dłużewska +5 more
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