Results 11 to 20 of about 10,376,430 (391)

Structural basis for substrate specificity of mammalian neuraminidases.

PLoS ONE, 2014
The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.
Victoria Smutova, Amgad Albohy, Xuefang Pan, Elena Korchagina, Taeko Miyagi, Nicolai Bovin, Christopher W Cairo, Alexey V Pshezhetsky   +7 more
doaj   +2 more sources

Probabilistic approach to predicting substrate specificity of methyltransferases.

PLoS Computational Biology, 2014
We present a general probabilistic framework for predicting the substrate specificity of enzymes. We designed this approach to be easily applicable to different organisms and enzymes.
Teresa Szczepińska, Jan Kutner, Michał Kopczyński, Krzysztof Pawłowski, Andrzej Dziembowski, Andrzej Kudlicki, Krzysztof Ginalski, Maga Rowicka   +7 more
doaj   +2 more sources

Phage-assisted continuous evolution of proteases with altered substrate specificity

Nature Communications, 2017
Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence ...
Michael S. Packer, Holly A. Rees, David R. Liu   +2 more
doaj   +2 more sources

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance COVID-19 is a deadly rampaging infectious disease with over 480 million cases worldwide. Unfortunately, effective therapies remain very limited. Novel antiviral agents are urgently needed to combat this global healthcare crisis.
Yao Zhao, Yan Zhu, Xiang Liu, Zhenming Jin, Yinkai Duan, Qi Zhang, Chengyao Wu, Lu Feng, Xiaoyu Du, Jinyi Zhao, Maolin Shao, Bing Zhang, Xiuna Yang, Lijie Wu, X. Ji, L. Guddat, Kailin Yang, Z. Rao, Haitao Yang   +18 more
semanticscholar   +1 more source

Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. [PDF]

PLoS ONE, 2016
In the present studies, we focused on substrate specificity of tocopherol cyclase, the key enzyme in the biosynthesis of the tocopherols and plastochromanol-8, the main plant lipid antioxidants, with special emphasis on the preference for tocopherols and
Jolanta Dłużewska, Renata Szymańska, Michal Gabruk, Peter B Kós, Beatrycze Nowicka, Jerzy Kruk   +5 more
doaj   +1 more source

Main Structural Targets for Engineering Lipase Substrate Specificity

Catalysts, 2020
Microbial lipases represent one of the most important groups of biotechnological biocatalysts. However, the high-level production of lipases requires an understanding of the molecular mechanisms of gene expression, folding, and secretion processes ...
Samah Hashim Albayati, M. Masomian, Siti Nor Hasmah Ishak, M. Ali, Adam Leow Thean, Fairolniza Mohd. Shariff, N. D. M. Noor, R. Rahman   +7 more
semanticscholar   +1 more source

An atlas of substrate specificities for the human serine/threonine kinome

Nature, 2023
Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson, Tomer M. Yaron, Emily M Huntsman, A. Kerelsky, Junho Song, Amit Regev, Ting Lin, Katarina M Liberatore, Daniel M. Cizin, Benjamin M. Cohen, N. Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, N. Käufer, M. Dorovkov, A. Ryazanov, Y. Takagi, Edward R. Kastenhuber, M. Goncalves, B. Hopkins, O. Elemento, D. Taatjes, A. Maucuer, A. Yamashita, A. Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, R. Linding, J. Blenis, P. Hornbeck, B. Turk, M. Yaffe, L. Cantley   +39 more
semanticscholar   +1 more source

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]

, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Baars, S, Cabedo, H, Donier, E, Garcia-Alonso, L, Gomez-Sanchez, JA, Grijota-Martinez, C, Lakomá, J   +6 more
core   +9 more sources

Substrate specificity of the human proteasome [PDF]

Chemistry & Biology, 2001
Regulated proteolysis by the proteasome is crucial for a broad array of cellular processes, from control of the cell cycle to production of antigens.The rules governing the N-terminal primary and extended substrate specificity of the human 20S proteasome in the presence or absence of 11S proteasome activators (REGalpha/beta and REGgamma) have been ...
Bradley J. Backes, Martin Rechsteiner, Phil B. Alper, Jun Li, Jennifer L. Harris   +4 more
openaire   +2 more sources

Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. [PDF]

PLoS ONE, 2015
Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P ...
Bryan M Zhao, Sarah L Keasey, Joseph E Tropea, George T Lountos, Beverly K Dyas, Scott Cherry, Sreejith Raran-Kurussi, David S Waugh, Robert G Ulrich   +8 more
doaj   +1 more source