Results 11 to 20 of about 10,558,845 (278)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase

Viruses, 2021
The ongoing COVID-19 pandemic exemplifies the general need to better understand viral infections. The positive single-strand RNA genome of its causative agent, the SARS coronavirus 2 (SARS-CoV-2), encodes all viral enzymes.
Roberto Benoni, Petra Krafcikova, Marek R. Baranowski, Joanna Kowalska, Evzen Boura, Hana Cahová   +5 more
doaj   +1 more source

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance COVID-19 is a deadly rampaging infectious disease with over 480 million cases worldwide. Unfortunately, effective therapies remain very limited. Novel antiviral agents are urgently needed to combat this global healthcare crisis.
Yao Zhao, Yan Zhu, Xiang Liu, Zhenming Jin, Yinkai Duan, Qi Zhang, Chengyao Wu, Lu Feng, Xiaoyu Du, Jinyi Zhao, Maolin Shao, Bing Zhang, Xiuna Yang, Lijie Wu, X. Ji, L. Guddat, Kailin Yang, Z. Rao, Haitao Yang   +18 more
semanticscholar   +1 more source

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]

, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Baars, S, Cabedo, H, Donier, E, Garcia-Alonso, L, Gomez-Sanchez, JA, Grijota-Martinez, C, Lakomá, J   +6 more
core   +9 more sources

Profiling of substrate specificity of SARS-CoV 3CL. [PDF]

PLoS ONE, 2010
BACKGROUND: The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-coronavirus is required for autoprocessing of the polyprotein, and is a potential target for treating coronaviral infection.
Chi-Pang Chuck, Lin-Tat Chong, Chao Chen, Hak-Fun Chow, David Chi-Cheong Wan, Kam-Bo Wong   +5 more
doaj   +1 more source

The Substrate Specificity of Pantethinase [PDF]

European Journal of Biochemistry, 1973
The substrate specificty of pantethinase, the mammalian enzyme which has been isolated from horse kidney cortex, has been studied. The real substrate has been found to be pantetheine in the reduced form, and the involvement of one or more—SH groups of the enzyme is also considered.A number of other compounds, chemically related to pantetheine, has also
Rosei Ma, Luisa Bellussi, Elena Del Grosso, Doriano Cavallini, Silvestro Duprè   +4 more
openaire   +3 more sources

Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. [PDF]

PLoS ONE, 2016
In the present studies, we focused on substrate specificity of tocopherol cyclase, the key enzyme in the biosynthesis of the tocopherols and plastochromanol-8, the main plant lipid antioxidants, with special emphasis on the preference for tocopherols and
Jolanta Dłużewska, Renata Szymańska, Michal Gabruk, Peter B Kós, Beatrycze Nowicka, Jerzy Kruk   +5 more
doaj   +1 more source

Probing ADAMTS13 substrate specificity using phage display. [PDF]

PLoS ONE, 2015
Von Willebrand factor (VWF) is a large, multimeric protein that regulates hemostasis by tethering platelets to the subendothelial matrix at sites of vascular damage.
Karl C Desch, Colin Kretz, Andrew Yee, Robert Gildersleeve, Kristin Metzger, Nidhi Agrawal, Jane Cheng, David Ginsburg   +7 more
doaj   +1 more source

Main Structural Targets for Engineering Lipase Substrate Specificity

Catalysts, 2020
Microbial lipases represent one of the most important groups of biotechnological biocatalysts. However, the high-level production of lipases requires an understanding of the molecular mechanisms of gene expression, folding, and secretion processes ...
Samah Hashim Albayati, M. Masomian, Siti Nor Hasmah Ishak, M. Ali, Adam Leow Thean, Fairolniza Mohd. Shariff, N. D. M. Noor, R. Rahman   +7 more
semanticscholar   +1 more source

An atlas of substrate specificities for the human serine/threonine kinome

Nature, 2023
Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson, Tomer M. Yaron, Emily M Huntsman, A. Kerelsky, Junho Song, Amit Regev, Ting Lin, Katarina M Liberatore, Daniel M. Cizin, Benjamin M. Cohen, N. Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E. van Vlimmeren, Nicole Andrée-Busch, N. Käufer, M. Dorovkov, A. Ryazanov, Y. Takagi, Edward R. Kastenhuber, M. Goncalves, B. Hopkins, O. Elemento, D. Taatjes, A. Maucuer, A. Yamashita, A. Degterev, Mohamed Uduman, Jingyi Lu, Sean D. Landry, Bin Zhang, Ian Cossentino, R. Linding, J. Blenis, P. Hornbeck, B. Turk, M. Yaffe, L. Cantley   +39 more
semanticscholar   +1 more source

Substrate specificity of the human proteasome [PDF]

Chemistry & Biology, 2001
Regulated proteolysis by the proteasome is crucial for a broad array of cellular processes, from control of the cell cycle to production of antigens.The rules governing the N-terminal primary and extended substrate specificity of the human 20S proteasome in the presence or absence of 11S proteasome activators (REGalpha/beta and REGgamma) have been ...
Bradley J. Backes, Martin Rechsteiner, Phil B. Alper, Jun Li, Jennifer L. Harris   +4 more
openaire   +2 more sources