Results 11 to 20 of about 10,438,012 (377)
The Substrate Specificity of Sirtuins.
Annual Review of Biochemistry, 2016 Sirtuins are NAD+-dependent enzymes universally present in all organisms, where they play central roles in regulating numerous biological processes. Although early studies showed that sirtuins deacetylated lysines in a reaction that consumes NAD+, more recent studies have revealed that these enzymes can remove a variety of acyl-lysine modifications ...
Poonam Bheda +3 more
semanticscholar +4 more sources
Substrate Specificity of Hexokinases
Journal of Biological Chemistry, 1961 Charles F. Lange, Paul M. Kohn
openalex +4 more sources
Profiling of substrate specificity of SARS-CoV 3CL. [PDF]
PLoS ONE, 2010 BACKGROUND: The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-coronavirus is required for autoprocessing of the polyprotein, and is a potential target for treating coronaviral infection.
Chi-Pang Chuck +5 more
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The Substrate Specificity of Pantethinase [PDF]
European Journal of Biochemistry, 1973 The substrate specificty of pantethinase, the mammalian enzyme which has been isolated from horse kidney cortex, has been studied. The real substrate has been found to be pantetheine in the reduced form, and the involvement of one or more—SH groups of the enzyme is also considered.A number of other compounds, chemically related to pantetheine, has also
Rosei Ma +4 more
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Tocopherol Cyclases-Substrate Specificity and Phylogenetic Relations. [PDF]
PLoS ONE, 2016 In the present studies, we focused on substrate specificity of tocopherol cyclase, the key enzyme in the biosynthesis of the tocopherols and plastochromanol-8, the main plant lipid antioxidants, with special emphasis on the preference for tocopherols and
Jolanta Dłużewska +5 more
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Probing ADAMTS13 substrate specificity using phage display. [PDF]
PLoS ONE, 2015 Von Willebrand factor (VWF) is a large, multimeric protein that regulates hemostasis by tethering platelets to the subendothelial matrix at sites of vascular damage.
Karl C Desch +7 more
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Main Structural Targets for Engineering Lipase Substrate Specificity
Catalysts, 2020 Microbial lipases represent one of the most important groups of biotechnological biocatalysts. However, the high-level production of lipases requires an understanding of the molecular mechanisms of gene expression, folding, and secretion processes ...
Samah Hashim Albayati +7 more
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An atlas of substrate specificities for the human serine/threonine kinome
Nature, 2023 Protein phosphorylation is one of the most widespread post-translational modifications in biology^ 1 , 2 . With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of serine and threonine phosphorylation have so far been identified, and ...
Jared L. Johnson +39 more
semanticscholar +1 more source
Substrate specificity of the human proteasome [PDF]
Chemistry & Biology, 2001 Regulated proteolysis by the proteasome is crucial for a broad array of cellular processes, from control of the cell cycle to production of antigens.The rules governing the N-terminal primary and extended substrate specificity of the human 20S proteasome in the presence or absence of 11S proteasome activators (REGalpha/beta and REGgamma) have been ...
Bradley J. Backes +4 more
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Substrate specificity of rat brain ceramidase
Journal of Lipid Research, 2002 In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of substrate
Samer El Bawab +5 more
doaj +1 more source