Results 11 to 20 of about 810,832 (336)

Do Amino Acid Antiporters Have Asymmetric Substrate Specificity?

Biomolecules, 2023
Amino acid antiporters mediate the 1:1 exchange of groups of amino acids. Whether substrate specificity can be different for the inward and outward facing conformation has not been investigated systematically, although examples of asymmetric transport ...
Gregory Gauthier-Coles, Stephen J. Fairweather, Angelika Bröer, Stefan Bröer   +3 more
doaj   +1 more source

Insights into the mechanism of substrate specificity in a novel PL15_3 subfamily oligo-alginate lyase VBAly15A. [PDF]

Appl Environ Microbiol
Tang Y, Song Z, Xu X, Li Y, Wang L.
europepmc   +2 more sources

Substrate specificity of rat brain ceramidase

Journal of Lipid Research, 2002
In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of substrate
Samer El Bawab, Julnar Usta, Patrick Roddy, Zdzislaw M. Szulc, Alicja Bielawska, Yusuf A. Hannun   +5 more
doaj   +1 more source

Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases

Nature Communications, 2021
Pinoresinol–lariciresinol reductases (PLRs) are enzymes involved in the lignan biosynthesis. Here, crystal structures of three PLRs in the apo, substrate-bound and product-bound states, and accompanying mutagenesis provide insight into PLRs catalytic ...
Ying Xiao, Kai Shao, Jingwen Zhou, Lian Wang, Xueqi Ma, Di Wu, Yingbo Yang, Junfeng Chen, Jingxian Feng, Shi Qiu, Zongyou Lv, Lei Zhang, Peng Zhang, Wansheng Chen   +13 more
doaj   +1 more source

Substrate specificity of human ceramide kinase

Journal of Lipid Research, 2005
Previous studies in our laboratory have established ceramide kinase (CERK) as a critical mediator of eicosanoid synthesis. To date, CERK has not been well characterized in vitro.
Dayanjan S. Wijesinghe, Autumn Massiello, Preeti Subramanian, Zdzislaw Szulc, Alicja Bielawska, Charles E. Chalfant   +5 more
doaj   +1 more source

Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate

Biomolecules, 2020
The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis.
Giacomo Parisi, Ida Freda, Cécile Exertier, Cristina Cecchetti, Elena Gugole, Gabriele Cerutti, Lucia D’Auria, Alberto Macone, Beatrice Vallone, Carmelinda Savino, Linda Celeste Montemiglio   +10 more
doaj   +1 more source

Evolution of substrate specificity in a retained enzyme driven by gene loss. [PDF]

, 2017
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that ...
Babnigg, Gyorgy, Barona-Gómez, Francisco, Carrillo-Tripp, Mauricio, Edirisinghe, Janaka N, Endres, Michael, Henry, Christopher S, Joachimiak, Andrzej, Juárez-Vázquez, Ana Lilia, Medina-Ruíz, Sofía, Michalska, Karolina, Noda-García, Lianet, Santoyo-Flores, Julián, Ton-That, Hung, Verduzco-Castro, Ernesto A, Wu, Chenggang   +14 more
core   +1 more source

Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit [PDF]

, 2011
The volatile compounds that constitute the fruit aroma of ripe tomato (Solanum lycopersicum) are often sequestered in glycosylated form. A homology-based screen was used to identify the gene SlUGT5, which is a member of UDP-glycosyltransferase 72 family ...
Alba, Baldwin, Birtic, Bowles, Brazier-Hicks, Brazier-Hicks, Brazier-Hicks, Buttery, Chervin, Fleuriet, Fukuchi-Mizutani, Gachon, Hansen, Hefner, Jones, Jones, Jugdé, Kino, Lairson, Lairson, Lanot, Lanot, Li, Lim, Loutre, Lunkenbein, Marlatt, Morris, Ortiz-Serrano, Pang, Ross, Sali, Schuettelkopf, Shimoda, Smart, Song, Syahrani, Tikunov, Wang, Witte, Yoon, Zanor   +41 more
core   +2 more sources

Comparative Studies on Retroviral Proteases: Substrate Specificity

Viruses, 2010
Exogenous retroviruses are subclassified into seven genera and include viruses that cause diseases in humans. The viral Gag and Gag-Pro-Pol polyproteins are processed by the retroviral protease in the last stage of replication and inhibitors of the HIV-1
József Tözsér
doaj   +1 more source

Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R [PDF]

, 2000
Background: Vaccinia virus gene B1R encodes a erine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection.
Beaud, G., Brown, N.G., Hardie, G., Leader, D.P., Morrice, D.N.   +4 more
core   +3 more sources