Results 61 to 70 of about 12,106 (297)
Algorithms, 2017 In order to relieve traffic congestion, irregularly-shaped bridges have been widely used in urban overpasses. However, the analysis on modal characteristics of irregularly-shaped bridges is not exhaustive, and the effect of design parameters on modal ...
Hanbing Liu +4 more
doaj +1 more source
Synthesis and properties of new chiral heterocyclic peptide mimetics
, 2008 The synthesis of tetrahydrofuran C(alpha)-tetrasubstituted amino acids (TAAs) and their effect on the conformation in small peptides are reported. The synthesis starts from the protein amino acid methionine, which is protected at the C and N terminus and
Maity, Prantik
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Substructure synthesis method for simulating large molecular complexes [PDF]
Proceedings of the National Academy of Sciences, 2002 This paper reports a computational method for describing the conformational flexibility of very large biomolecular complexes using a reduced number of degrees of freedom. It is called the substructure synthesis method, and the basic concept is to treat the motions of a given structure as a collection of those of an assemblage of substructures.
Dengming, Ming +3 more
openaire +2 more sources
Torsional vibration analysis of automotive drivelines [PDF]
, 1997 One of the most important source of noise and vibrations associated with vehicles is the vibration of driveline systems. Such phenomena are subjectively associated with customer complaints.
Rabeih, El-Adl Mohammed Aly
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Substructure Synthesis Method using Dynamic Reduction [PDF]
Substructure Synthesis Method using Dynamic Reduction analysis on structures. In these days, it is a very common method for not only a simple vibration analysis but also the optimization of structures. However, when we apply that method for the
김성우
core
, 2016 A convergent synthesis of quinolone 2 (key substructure of the protease inhibitor BILN 2061) was developed via palladium-catalyzed carbonylation of 2-iodo-5-methoxyaniline (4) with thiazolylacetylene ...
Nizar Haddad (1392799) +2 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source