Results 1 to 10 of about 501,183 (359)

Architecture of the subthalamic nucleus [PDF]

Communications Biology
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad, Åsa Wallén-Mackenzie   +1 more
doaj   +3 more sources

Unraveling the enigmatic role of the subthalamic nucleus [PDF]

eLife
Subpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
doaj   +3 more sources

Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia [PDF]

PLoS One. 2012; 7(12): e51530, 2012
Neural activity in the brain of parkinsonian patients is characterized by the intermittently synchronized oscillatory dynamics. This imperfect synchronization, observed in the beta frequency band, is believed to be related to the hypokinetic motor symptoms of the disorder. Our study explores potential mechanisms behind this intermittent synchrony.
Park, Choongseok, Rubchinsky, Leonid
arxiv   +11 more sources

Neurotransmitter and receptor systems in the subthalamic nucleus. [PDF]

Brain Struct Funct, 2023
AbstractThe Subthalamic Nucleus (STh) is a lens-shaped subcortical structure located ventrally to the thalamus, that despite being embryologically derived from the diencephalon, is functionally implicated in the basal ganglia circuits. Because of this strict structural and functional relationship with the circuits of the basal ganglia, the STh is a ...
Emmi A, Campagnolo M, Stocco E, Carecchio M, Macchi V, Antonini A, De Caro R, Porzionato A.   +7 more
europepmc   +5 more sources

Subthalamic nucleus shows opposite functional connectivity pattern in Huntington's and Parkinson's disease. [PDF]

Brain Commun, 2023
Huntington's and Parkinson's disease are two movement disorders representing mainly opposite states of the basal ganglia inhibitory function. Despite being an integral part of the cortico-subcortico-cortical circuitry, the subthalamic nucleus function ...
Evangelisti S, Boessenkool S, Pflanz CP, Basting R, Betts JF, Jenkinson M, Clare S, Muhammed K, LeHeron C, Armstrong R, Klein JC, Husain M, Nemeth AH, Hu MT, Douaud G.   +14 more
europepmc   +3 more sources

In Parkinson’s disease dopaminergic medication and deep brain stimulation of the subthalamic nucleus increase motor, but not reflection and cognitive impulsivity [PDF]

Frontiers in Neuroscience
BackgroundParkinson’s disease is associated with increased impulsivity, which can be divided into several domains: motor (consisting of proactive and reactive subdomains), reflection, and cognitive impulsivity.
Martijn Hendriks, Martijn Hendriks, Saman Vinke, Rok Berlot, Rok Berlot, Mitja Benedičič, Marjan Jahansahi, Maja Trošt, Maja Trošt, Dejan Georgiev, Dejan Georgiev   +10 more
doaj   +2 more sources

Subthalamic Nucleus: Neuroanatomical Review [PDF]

Brazilian Neurosurgery, 2017
Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães, Claudiojanes dos Reis, Juliana Rabelo da Silva Sousa, Victória Souza Marques, Tayná Cardoso Gonçalves, Iara Cristina Vieira Ribeiro, Leide Daiana Silveira Cardoso, Victor Caribé Crosland Guimarães, Frederico Gustavo de Souza Marques, Sarah Dias Pereira   +9 more
doaj   +3 more sources

Dopamine Dysregulation Syndrome and Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease [PDF]

Neurology Research International, 2011
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment in Parkinson's disease that may be very disabling due to the negative impact that compulsive medication use may have on patients' social, psychological, and physical ...
Beatriz De la Casa-Fages, Francisco Grandas   +1 more
doaj   +4 more sources

The subthalamic nucleus in the context of movement disorders [PDF]

Brain, 2003
The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia output. It receives its major afferents from the cerebral cortex, thalamus, globus pallidus externus and brainstem, and projects mainly to both segments of the globus pallidus, substantia nigra, striatum and brainstem.
Clement Hamani
openalex   +4 more sources

Are there three Subdivisions in the primate Subthalamic Nucleus? [PDF]

Frontiers in Neuroanatomy, 2012
The prevailing academic opinion holds that the subthalamic nucleus (STN) consists of three parts, each anatomically distinct and selectively associated with cognitive, emotional, or motor functioning.
Max C Keuken, Max C Keuken, Harry B.M. Uylings, Stefan eGeyer, Andreas eSchäfer, Robert eTurner, Birte U Forstmann, Birte U Forstmann   +7 more
doaj   +7 more sources