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Subthalamic Nucleus: Neuroanatomical Review [PDF]

open access: yesBrazilian Neurosurgery, 2017
Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães   +9 more
doaj   +4 more sources

Architecture of the subthalamic nucleus [PDF]

open access: yesCommunications Biology
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad   +1 more
doaj   +4 more sources

Unraveling the enigmatic role of the subthalamic nucleus [PDF]

open access: yeseLife
Subpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
doaj   +4 more sources

Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia

open access: yesNature Communications, 2022
Chemogenetic inactivation of the subthalamic nucleus in monkeys increases spike train variability in the pallidum and prolongs movement time, suggesting its role in stabilizing pallidal spike trains to achieve stable motor control.
Taku Hasegawa   +3 more
doaj   +2 more sources

Pain in Parkinson's disease and the role of the subthalamic nucleus.

open access: yesBrain, 2021
Pain is a frequent and poorly treated symptom of Parkinson's disease, mainly due to scarce knowledge of its basic mechanisms. In Parkinson's disease, deep brain stimulation of the subthalamic nucleus is a successful treatment of motor symptoms, but also ...
A. Mostofi   +4 more
semanticscholar   +5 more sources

Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects in GBA Mutation Carriers

open access: yesAnnals of Neurology, 2022
This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson disease.
Gian D Pal   +30 more
semanticscholar   +1 more source

Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease

open access: yesScience Translational Medicine, 2022
Disruption of subthalamic nucleus dynamics in Parkinson’s disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson’s ...
Yohann Thenaisie   +16 more
semanticscholar   +1 more source

Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease

open access: yesNeural Regeneration Research, 2023
There are many documented sex differences in the clinical course, symptom expression profile, and treatment response of Parkinson’s disease, creating additional challenges for patient management.
Tian-Shuo Yuan   +7 more
doaj   +1 more source

Effects of bilateral subthalamic nucleus deep brain stimulation on motor symptoms in Parkinson’s disease: a retrospective cohort study

open access: yesNeural Regeneration Research, 2021
Deep brain stimulation of the bilateral subthalamic nucleus (STN) is a therapeutic option for patients with Parkinson’s disease (PD) in whom medical therapies have been ineffective.
Guo-Xiong Cheng   +6 more
doaj   +1 more source

Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms

open access: yesBiomedical Papers, 2022
Background. In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. Methods.
Jan Bardon   +15 more
doaj   +1 more source

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