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Architecture of the subthalamic nucleus [PDF]
Communications BiologyThe subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad +1 more
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Unraveling the enigmatic role of the subthalamic nucleus [PDF]
eLifeSubpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
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Nature Communications, 2022 Chemogenetic inactivation of the subthalamic nucleus in monkeys increases spike train variability in the pallidum and prolongs movement time, suggesting its role in stabilizing pallidal spike trains to achieve stable motor control.
Taku Hasegawa +3 more
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Subthalamic Nucleus: Neuroanatomical Review [PDF]
Brazilian Neurosurgery, 2017 Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães +9 more
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Pain in Parkinson’s disease and the role of the subthalamic nucleus
Brain, 2021 Abstract Pain is a frequent and poorly treated symptom of Parkinson’s disease, mainly due to scarce knowledge of its basic mechanisms. In Parkinson’s disease, deep brain stimulation of the subthalamic nucleus is a successful treatment of motor symptoms, but also might be effective in treating pain. However, it has been unclear which type
Peter Brown +5 more
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Neurotransmitter and receptor systems in the subthalamic nucleus. [PDF]
Brain Struct Funct, 2023 AbstractThe Subthalamic Nucleus (STh) is a lens-shaped subcortical structure located ventrally to the thalamus, that despite being embryologically derived from the diencephalon, is functionally implicated in the basal ganglia circuits. Because of this strict structural and functional relationship with the circuits of the basal ganglia, the STh is a ...
Emmi A +7 more
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The subthalamic nucleus, oscillations, and conflict [PDF]
Movement Disorders, 2015 AbstractThe subthalamic nucleus (STN), which is currently the most common target for deep brain stimulation (DBS) for Parkinson's disease (PD), has received increased attention over the past few years for the roles it may play in functions beyond simple motor control.
Kareem A. Zaghloul +3 more
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In Parkinson’s disease dopaminergic medication and deep brain stimulation of the subthalamic nucleus increase motor, but not reflection and cognitive impulsivity [PDF]
Frontiers in NeuroscienceBackgroundParkinson’s disease is associated with increased impulsivity, which can be divided into several domains: motor (consisting of proactive and reactive subdomains), reflection, and cognitive impulsivity.
Martijn Hendriks +10 more
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Are there three Subdivisions in the primate Subthalamic Nucleus? [PDF]
Frontiers in Neuroanatomy, 2012 The prevailing academic opinion holds that the subthalamic nucleus (STN) consists of three parts, each anatomically distinct and selectively associated with cognitive, emotional, or motor functioning.
Max C Keuken +7 more
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The subthalamic nucleus in the context of movement disorders [PDF]
Brain, 2003 The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia output. It receives its major afferents from the cerebral cortex, thalamus, globus pallidus externus and brainstem, and projects mainly to both segments of the globus pallidus, substantia nigra, striatum and brainstem.
Clement Hamani
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