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Architecture of the subthalamic nucleus
Communications BiologyThe subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad +1 more
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Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease
Science Translational Medicine, 2022 Disruption of subthalamic nucleus dynamics in Parkinson’s disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson’s ...
Yohann Thenaisie +16 more
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Definitions, 2020 The paired, biconvex cluster of neurons located under the thalamus that plays a major role in the motor cortico-basal ganglia-thalamo-cortical circuit. The subthalamic nucleus is primary involved in the control of voluntary movement.
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Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance [PDF]
Journal of Neuroscience, 2018 Considerable evidence suggests a role of beta-band oscillations in voluntary movements. However, most of the studies linking beta power to motor performance are based on data averaged across trials that ignore the fast dynamics of oscillatory activity ...
Flavie Torrecillos +10 more
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Computational Modeling of Ultrasonic Subthalamic Nucleus Stimulation [PDF]
IEEE Transactions on Biomedical Engineering, 2018 To explore the potential of ultrasonic modulation of plateau-potential generating subthalamic nucleus neurons (STN), by modeling their interaction with continuous and pulsed ultrasonic waves.A computational model for ultrasonic stimulation of the STN is created by combining the Otsuka-model with the bilayer sonophore model.
Thomas Tarnaud +3 more
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Subthalamic Nucleus: Neuroanatomical Review [PDF]
Brazilian Neurosurgery, 2017 Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães +9 more
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Nature Communications, 2022 Chemogenetic inactivation of the subthalamic nucleus in monkeys increases spike train variability in the pallidum and prolongs movement time, suggesting its role in stabilizing pallidal spike trains to achieve stable motor control.
Taku Hasegawa +3 more
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Unraveling the enigmatic role of the subthalamic nucleus [PDF]
eLifeSubpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
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Annals of Neurology, 2022 This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson disease.
Gian D Pal +30 more
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