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Subthalamic Nucleus: Neuroanatomical Review [PDF]
Brazilian Neurosurgery, 2017 Discovered in 1865 by Jules Bernard Luys, the subthalamic nucleus is a set of small nuclei located in the diencephalon, inferior to the thalamus and superior to the substantia nigra, that can be visualized in a posterior coronal section.
Marcelo José Silva de Magalhães +9 more
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Architecture of the subthalamic nucleus [PDF]
Communications BiologyThe subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad +1 more
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Unraveling the enigmatic role of the subthalamic nucleus [PDF]
eLifeSubpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
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Nature Communications, 2022 Chemogenetic inactivation of the subthalamic nucleus in monkeys increases spike train variability in the pallidum and prolongs movement time, suggesting its role in stabilizing pallidal spike trains to achieve stable motor control.
Taku Hasegawa +3 more
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Pain in Parkinson's disease and the role of the subthalamic nucleus.
Brain, 2021 Pain is a frequent and poorly treated symptom of Parkinson's disease, mainly due to scarce knowledge of its basic mechanisms. In Parkinson's disease, deep brain stimulation of the subthalamic nucleus is a successful treatment of motor symptoms, but also ...
A. Mostofi +4 more
semanticscholar +5 more sources
Annals of Neurology, 2022 This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson disease.
Gian D Pal +30 more
semanticscholar +1 more source
Principles of gait encoding in the subthalamic nucleus of people with Parkinson’s disease
Science Translational Medicine, 2022 Disruption of subthalamic nucleus dynamics in Parkinson’s disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson’s ...
Yohann Thenaisie +16 more
semanticscholar +1 more source
Neural Regeneration Research, 2023 There are many documented sex differences in the clinical course, symptom expression profile, and treatment response of Parkinson’s disease, creating additional challenges for patient management.
Tian-Shuo Yuan +7 more
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Neural Regeneration Research, 2021 Deep brain stimulation of the bilateral subthalamic nucleus (STN) is a therapeutic option for patients with Parkinson’s disease (PD) in whom medical therapies have been ineffective.
Guo-Xiong Cheng +6 more
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Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms
Biomedical Papers, 2022 Background. In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. Methods.
Jan Bardon +15 more
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