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PLoS ONE, 2020 BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on ...
Felicitas Ehlen +3 more
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Communications Biology, 2020 The subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain disorders, including Parkinsonʼs disease and obsessive compulsive disorder (OCD), for which high-frequency ...
Å. Wallén-Mackenzie +6 more
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Aversion encoded in the subthalamic nucleus [PDF]
, 2020 AbstractActivation of the subthalamic nucleus (STN) is associated with the stopping of ongoing behavior via the basal ganglia. However, we recently observed that optogenetic STN excitation induced a strong jumping/escaping behavior. We hypothesized that STN activation is aversive. To test this, place preference was assessed.
Gian Pietro Serra +6 more
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The role of the subthalamic nucleus in cognition [PDF]
Reviews in the Neurosciences, 2013 Because the complex functions of the basal ganglia have been increasingly studied over the past several decades, the understanding of the role of the subthalamic nucleus (STN) in motor and cognitive functions has evolved. The traditional role in motor function ascribed to the STN, based on its involvement in the cortico-striato-thalamo-cortical motor ...
Kareem A. Zaghloul, David B. Weintraub
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Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease
Movement Disorders, 2020 Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under subthalamic nucleus deep brain stimulation.
Yvan M. Vachez +7 more
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Frontiers in Neuroscience, 2022 The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits.
Aron Emmi +15 more
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Definitions, 2020 The paired, biconvex cluster of neurons located under the thalamus that plays a major role in the motor cortico-basal ganglia-thalamo-cortical circuit. The subthalamic nucleus is primary involved in the control of voluntary movement.
semanticscholar +1 more source
Frontiers in Systems Neuroscience, 2011 Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson’s disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus.
Rachida eAmmari +4 more
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Transcriptional Profile of the Developing Subthalamic Nucleus
eneuro, 2022 AbstractThe subthalamic nucleus (STN) is a small, excitatory nucleus that regulates the output of basal ganglia motor circuits. The functions of the STN and its role in the pathophysiology of Parkinson’s disease are now well established. However, some basic characteristics like the developmental origin and molecular phenotype of neuronal subpopulations
Ema Bokulić +2 more
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The next step for imaging the subthalamic nucleus [PDF]
Brain, 2016 Sir, We read with interest the recently published study by Accolla and colleagues (2016) on brain networks modulated by subthalamic nucleus deep brain stimulation (DBS; Accolla et al. , 2016). In their study, the authors combined neurophysiological recordings with MRI to obtain much needed, more detailed information on the functional organization of ...
Birte U. Forstmann +5 more
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