Results 1 to 10 of about 21,077 (167)

Unraveling the enigmatic role of the subthalamic nucleus [PDF]

eLife
Subpopulations of neurons in the subthalamic nucleus have distinct activity patterns that relate to the three hypotheses of the Drift Diffusion Model.
Qianli Yang
doaj   +2 more sources

Architecture of the subthalamic nucleus [PDF]

Communications Biology
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain stimulation (DBS). STN-DBS is today applied as treatment in Parkinson´s disease, dystonia, essential tremor,
Asheeta A. Prasad, Åsa Wallén-Mackenzie   +1 more
doaj   +2 more sources

Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease

Neural Regeneration Research, 2023
There are many documented sex differences in the clinical course, symptom expression profile, and treatment response of Parkinson’s disease, creating additional challenges for patient management.
Tian-Shuo Yuan, Ying-Chuan Chen, De-Feng Liu, Ruo-Yu Ma, Xin Zhang, Ting-Ting Du, Guan-Yu Zhu, Jian-Guo Zhang   +7 more
doaj   +1 more source

Dexmedetomidine depresses neuronal activity in the subthalamic nucleus during deep brain stimulation electrode implantation surgery

BJA Open, 2022
Background: Micro-electrode recordings are often necessary during electrode implantation for deep brain stimulation of the subthalamic nucleus. Dexmedetomidine may be a useful sedative for these procedures, but there is limited information regarding its ...
Corey Amlong, Deborah Rusy, Robert D. Sanders, Wendell Lake, Aeyal Raz   +4 more
doaj   +1 more source

Effects of bilateral subthalamic nucleus deep brain stimulation on motor symptoms in Parkinson’s disease: a retrospective cohort study

Neural Regeneration Research, 2021
Deep brain stimulation of the bilateral subthalamic nucleus (STN) is a therapeutic option for patients with Parkinson’s disease (PD) in whom medical therapies have been ineffective.
Guo-Xiong Cheng, Shu-Bin Yin, Ying-Hao Yang, Yuan-Hu Hu, Chih-Yang Huang, Qian-Ming Yao, Wei-Jen Ting   +6 more
doaj   +1 more source

Subthalamic Nucleus Degeneration As A Dark Cause of Parkinson’s Disease Due to Subarachnoid Hemorrhage: A Preliminary Experimental Study

Journal of Contemporary Medicine, 2023
Background: Although the subtahalamic nucleus degeneration has been accused of Parkinson’s disease, the obscure roles of subtalamic nucleus degeneration induced by subarachnoid hemorrhages has not been adequately studied.
Mehmet Hakan Şahin, Mete Zeynal
doaj   +1 more source

Deep brain stimulation electrode position impact on parkinsonian non-motor symptoms

Biomedical Papers, 2022
Background. In this study we evaluated the impact of location of deep brain stimulation electrode active contact in different parts of the subthalamic nucleus on improvement of non-motor symptoms in patients with Parkinson's disease. Methods.
Jan Bardon, Sandra Kurcova, Monika Chudackova, Pavel Otruba, David Krahulik, Martin Nevrly, Petr Kanovsky, Jana Zapletalova, Jan Valosek, Petr Hlustik, Miroslav Vastik, Marketa Vecerkova, Lenka Hvizdosova, Katerina Mensikova, Egon Kurca, Stefan Sivak   +15 more
doaj   +1 more source

Dysconnectivity of the parafascicular nucleus in Parkinson's disease: A dynamic causal modeling analysis

Neurobiology of Disease, 2023
Background: Recent animal model studies have suggested that the parafascicular nucleus has the potential to be an effective deep brain stimulation target for Parkinson's disease.
Lili Chen, Junyan Sun, Linlin Gao, Junling Wang, Jinghong Ma, Erhe Xu, Dongling Zhang, Liang Li, Tao Wu   +8 more
doaj   +1 more source

Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson's disease.

PLoS ONE, 2020
BackgroundIn addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on ...
Felicitas Ehlen, Bassam Al-Fatly, Andrea A Kühn, Fabian Klostermann   +3 more
doaj   +1 more source

Subacute alpha frequency (10Hz) subthalamic stimulation for emotional processing in Parkinson's disease

Brain Stimulation, 2023
Background: Psychiatric comorbidities are common in Parkinson's disease (PD) and may change with high-frequency stimulation targeting the subthalamic nucleus.
Linbin Wang, Jun Li, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon   +5 more
doaj   +1 more source