Results 111 to 120 of about 17,568 (222)

Florzolotau (18F) retention is linked to neuropsychological performance in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Florzolotau (18F) positron emission tomography visualizes three‐ and four‐repeat tau isoforms. We aimed to evaluate correlation of tau tracer retention with neuropsychological performance across the Alzheimer's disease (AD) continuum and non‐AD tauopathies.
Atsushi Shimizu, Yu Iwabuchi, Shogyoku Bun, Memi Watanabe, Masahito Kubota, Sho Shimohama, Toshiki Tezuka, Keisuke Takahata, Hajime Tabuchi, Morinobu Seki, Yuki Momota, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Shin Kurose, Ryosuke Sakurai, Toshiki Takayama, Yuka Hoshino, Takayuki Hoshino, Natsumi Suzuki, Ayaka Morimoto, Azusa Osumi, Masaru Mimura, Masahiro Jinzaki, Daisuke Ito   +24 more
wiley   +1 more source

Clinical and Biological Determinants of Longitudinal Cognitive Function in Patients With GBA1 Variants and Subthalamic Deep Brain Stimulation

Annals of Neurology, Volume 99, Issue 4, Page 976-988, April 2026.
Objective Whether cognitive decline in patients with Parkinson's disease (PD) carrying GBA1 variants is accelerated after subthalamic deep brain stimulation (STN‐DBS) remains controversial. Clarifying long‐term cognitive outcomes is essential for informed decision making.
Moritz A. Loeffler, Philipp Klocke, Isabel Wurster, Stefanie Lerche, Idil Cebi, Thomas Gasser, Alireza Gharabaghi, Kathrin Brockmann, Daniel Weiss   +8 more
wiley   +1 more source

Oval Subthalamic Nucleus [PDF]

, 2020
openaire   +1 more source

Trick or Treat: Unintentional Cannabis Intoxication From Edibles in a Preschool Child—A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
Case report on a 5‐year‐old female patient presenting with various organic symptoms after consumption of tetrahydrocannabinol (THC)‐containing gummy bears. Icons provided by Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/).
Eileen Heiler, Saskia Wedegärtner, Dennis Nordhoff, Eckard Hamelmann, Janina Soler Wenglein   +4 more
wiley   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya, Kirsteen N. Browning   +1 more
wiley   +1 more source

Using FoxP2 to Distinguish Direct and Indirect Basal Ganglia Pathways for Vocal Learning in Songbirds

Developmental Neurobiology, Volume 86, Issue 2, April 2026.
ABSTRACT The cortico‐basal ganglia pathways that mediate vocal learning in zebra finches (Taeniopygia guttata) are localized in parallel circuits formed by CORE and SHELL subregions. These circuits traverse a specialized region of the basal ganglia essential for vocal learning (Area X), which includes intermixed striatal and pallidal neurons.
Aditi Jagannathan, Mira Nigudkar, Sarah W. Bottjer   +2 more
wiley   +1 more source

The subthalamic nucleus, part II

, 2008
Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation.
Heida, Tjitske, Marani, Enrico, Usunoff, Kamen G.   +2 more
openaire   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Model-based design of subthalamic nucleus neurons using hybrid optimization. [PDF]

J Neurophysiol
Chen H, McIntyre CC.
europepmc   +1 more source

Subthalamic nucleus in patients with Parkinson's disease encodes changes and magnitude of applied force. [PDF]

NPJ Parkinsons Dis
Olson J, Wahid SS, Irwin ZT, Kuhman D, Gonzalez CL, Boolos M, Black S, Guthrie BL, Wichmann T, Walker HC.   +9 more
europepmc   +1 more source