Results 61 to 70 of about 502,362 (345)

Imaging of the human subthalamic nucleus

, 2021
The human subthalamic nucleus (STN) is a small lens shaped iron rich nucleus, which has gained substantial interest as a target for deep brain stimulation surgery for a variety of movement disorders. The internal anatomy of the human STN has not been fully elucidated, and an intensive debate, discussing the level of overlap between putative limbic ...
Alkemade, A., Forstmann, B.U.
openaire   +3 more sources

Is Deep Brain Stimulation a viable treatment for substance-related addiction? [PDF]

Romanian Journal of Neurology, 2019
For the ability to modulate the activity of dysregulated networks Deep Brain Stimulation (DBS) of areas involved in reward system and motivational states may have a potential application in addiction despite risks associated with its invasiveness.
Giusy Guzzi, Angelo Lavano, Serena Marianna Lavano, Rosa Marotta   +3 more
doaj   +1 more source

Brain tissue properties differentiate between motor and limbic basal ganglia circuits [PDF]

, 2014
Despite advances in understanding basic organizational principles of the human basal ganglia, accurate in vivo assessment of their anatomical properties is essential to improve early diagnosis in disorders with corticosubcortical pathology and optimize ...
Accolla, EA, Chowdhury, R, Draganski, B, Dukart, J, Haynes, J-D, Helms, G, Hetzer, S, Kherif, F, Kühn, AA, Lutti, A, Weiskopf, N   +10 more
core   +2 more sources

Dopamine Dysregulation Syndrome and Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Neurology Research International, 2011
Dopamine dysregulation syndrome is a complication of the dopaminergic treatment in Parkinson's disease that may be very disabling due to the negative impact that compulsive medication use may have on patients' social, psychological, and physical ...
Beatriz De la Casa-Fages, Francisco Grandas   +1 more
doaj   +1 more source

Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives

eNeuro, 2017
Over the last decades, extensive basic and clinical knowledge has been acquired on the use of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson’s disease (PD). It is now clear that mechanisms involved in the effects of this therapy are
C. Hamani, G. Florence, H. Heinsen, B. Plantinga, Y. Temel, K. Uludağ, E. Alho, M. Teixeira, E. Amaro, E. Fonoff   +9 more
semanticscholar   +1 more source

Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control [PDF]

Cerebral Cortex Communications, 2020
AbstractPatients with Parkinson’s disease (PD) often experience reductions in the proficiency to inhibit actions. The motor symptoms of PD can be effectively treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN), a key structure in the frontal–striatal network that may be directly involved in regulating inhibitory control. However,
van Wouwe, N.C., Neimat, J.S., van den Wildenberg, W.P.M., Hughes, S.B., Lopez, A.M., Phibbs, F.T., Schall, J.D., Rodriguez, W.J., Bradley, E.B., Dawant, B.M., Wylie, S.A.   +10 more
openaire   +3 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Cortico-basal white matter alterations occurring in Parkinson's disease.

PLoS ONE, 2019
Magnetic resonance imaging studies typically use standard anatomical atlases for identification and analyses of (patho-)physiological effects on specific brain areas; these atlases often fail to incorporate neuroanatomical alterations that may occur with
Bethany R Isaacs, Anne C Trutti, Esther Pelzer, Marc Tittgemeyer, Yasin Temel, Birte U Forstmann, Max C Keuken   +6 more
doaj   +1 more source

Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation

Frontiers in Systems Neuroscience, 2011
High frequency deep-brain stimulation of the subthalamic nucleus (DBS) relieves many of the symptoms of Parkinson's disease in humans and animal models. Although the treatment has seen widespread use, its therapeutic mechanism remains paradoxical. The
Charles J Wilson, Bryce eBeverlin, Theoden I Netoff   +2 more
doaj   +1 more source

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources