Subthalamic nucleus high-frequency stimulation restores altered electrophysiological properties of cortical neurons in parkinsonian rat. [PDF]
PLoS ONE, 2013 Electrophysiological recordings performed in parkinsonian patients and animal models have confirmed the occurrence of alterations in firing rate and pattern of basal ganglia neurons, but the outcome of these changes in thalamo-cortical networks remains ...
Bertrand Degos +3 more
doaj +1 more source
Coupled effects of channels and synaptic dynamics in stochastic modelling of healthy and Parkinson's-disease-affected brains [PDF]
arXiv, 2021 Our brain is a complex information processing network in which the nervous system receives information from the environment to quickly react to incoming events or learns from experience to sharp our memory. In the nervous system, the brain states translate collective activities of neurons interconnected via synaptic connections. In this paper, we study
arxiv
Mean-field modeling of the basal ganglia-thalamocortical system. II. Dynamics of parkinsonian oscillations [PDF]
J. Theor. Biol. 257:664-688 (2009), 2018 Neuronal correlates of Parkinson's disease (PD) include a slowing of the electroencephalogram (EEG) and enhanced synchrony at 3-7 and 7-30 Hz in the basal ganglia, thalamus, and cortex. This study describes the dynamics of a physiologically based mean-field model of the basal ganglia-thalamocortical system, and shows how it accounts for key ...
arxiv +1 more source
Movement Disorders, 2016 A novel neurostimulation system allows steering current in horizontal directions by combining segmented leads and multiple independent current control.
F. Steigerwald +4 more
semanticscholar +1 more source
Phase matters: A role for the subthalamic network during gait. [PDF]
PLoS ONE, 2018 The role of the subthalamic nucleus in human locomotion is unclear although relevant, given the troublesome management of gait disturbances with subthalamic deep brain stimulation in patients with Parkinson's disease.
Gabriele Arnulfo +9 more
doaj +1 more source
Deep brain stimulation for movement disorder treatment: Exploring frequency-dependent efficacy in a computational network model [PDF]
arXiv, 2020 A large scale computational model of the basal ganglia (BG) network is proposed to describes movement disorder including deep brain stimulation (DBS). The model of this complex network considers four areas of the basal ganglia network: the subthalamic nucleus (STN) as target area of DBS, globus pallidus, both pars externa and pars interna (GPe-GPi ...
arxiv
A Multiple Kernel Learning Approach for Human Behavioral Task Classification using STN-LFP Signal [PDF]
, 2016 Deep Brain Stimulation (DBS) has gained increasing attention as an effective method to mitigate Parkinsons disease (PD) disorders. Existing DBS systems are open-loop such that the system parameters are not adjusted automatically based on patients behavior. Classification of human behavior is an important step in the design of the next generation of DBS
arxiv +1 more source
Local vs. volume conductance activity of field potentials in the human subthalamic nucleus.
Journal of Neurophysiology, 2017 Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume ...
O. Marmor +8 more
semanticscholar +1 more source
Frontiers in Integrative Neuroscience, 2012 Accurately describing the spiking patterns of neurons in the subthalamic nucleus of patients suffering from Parkinson’s disease is important for understanding the pathogenesis of the disease and for achieving the maximum therapeutic benefit from deep ...
Uri eEden +3 more
doaj +1 more source
Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease. [PDF]
PLoS ONE, 2012 The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 ...
Filip Růžička +5 more
doaj +1 more source