Results 31 to 40 of about 81,530 (252)

A molecular signature of lung-resident CD8+ T cells elicited by subunit vaccination

Scientific Reports, 2022
Natural infection as well as vaccination with live or attenuated viruses elicit tissue resident, CD8+ memory T cell (Trm) response. Trm cells so elicited act quickly upon reencounter with the priming agent to protect the host.
Naveenchandra Suryadevara, Amrendra Kumar, Xiang Ye, Meredith Rogers, John V. Williams, John T. Wilson, John Karijolich, Sebastian Joyce   +7 more
doaj   +1 more source

Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice

iScience, 2022
Summary: Efficient delivery of subunit vaccines to dendritic cells (DCs) is necessary to improve vaccine efficacy, because the vaccine antigen alone cannot induce sufficient protective immunity.
Teppei Matsuda, Kazuki Misato, Shigeyuki Tamiya, Yasuhiro Akeda, Ikuhiko Nakase, Etsushi Kuroda, Shokichi Takahama, Motohiro Nonaka, Takuya Yamamoto, Michiko N. Fukuda, Yasuo Yoshioka   +10 more
doaj   +1 more source

Alkaline-extracted influenza subunit vaccine [PDF]

Infection and Immunity, 1976
Treatment of influenza virus concentrates with alkaline solvents releases a major fraction of the viral structural protein content. As determined by polyacrylamide gel electrophoresis, the surface glycoprotein substructures, hemagglutinin and neuraminidase, are the primary solubilized products.
openaire   +2 more sources

Evaluating passive immunity in piglets from sows vaccinated with a PEDV S protein subunit vaccine

Frontiers in Cellular and Infection Microbiology
Porcine epidemic diarrhea virus (PEDV) is a highly contagious virus that causes severe diarrhea and high mortality in neonatal piglets. Current control measures, such as inactivated and live-attenuated vaccines, have limitations in providing complete ...
Jiajia Liu, Jiajia Liu, Guangli Hu, Shengjin Liu, Guangcai Ren, Liguo Gao, Liguo Gao, Zhiqing Zhao, Rui Geng, Dingli Wang, Xiao Shen, Feng Chen, Hanqin Shen, Hanqin Shen   +13 more
doaj   +1 more source

Subunit Recombinant Vaccine Protects against Monkeypox [PDF]

The Journal of Immunology, 2006
Abstract The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response.
Heraud, Jean-Michel, Edghill-Smith, Yvette, Ayala, Victor, Kalisz, Irene, Parrino, Janie, Kalyanaraman, Vaniambadi, Manischewitz, Jody, King, Lisa, Hryniewicz, Anna, Trindade, Christopher, Hassett, Meredith, Tsai, Wen-Po, Venzon, David, Nalca, Aysegul, Vaccari, Monica, Silvera, Peter, Bray, Mike, Graham, Barney, Golding, Hana, Hooper, Jay, Franchini, Genoveffa   +20 more
openaire   +3 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, EarlyView.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

Novel Immunoinformatics Approaches to Design Multi-epitope Subunit Vaccine for Malaria by Investigating Anopheles Salivary Protein

Scientific Reports, 2018
Malaria fever has been pervasive for quite a while in tropical developing regions causing high morbidity and mortality. The causal organism is a protozoan parasite of genus Plasmodium which spreads to the human host by the bite of hitherto infected ...
Rajan Kumar Pandey, Tarun Kumar Bhatt, Vijay Kumar Prajapati   +2 more
doaj   +1 more source

Evaluation of Seasonal Inactivated Influenza Vaccines Prophylactic Efficacy

Эпидемиология и вакцинопрофилактика, 2022
Relevance. Seasonal flu vaccination is still the most effective way to protect against flu viruses and help to reduce the burden of flu illnesses. Another possible benefit is the impact of yearly vaccines on severity of breakthrough infection.
K. V. Zhdanov, K. Kasyanenko, O. V. Mal'cev, N. I. L'vov, D. A. Lioznov, I. I. Lapikov, K. S. Ivanov   +6 more
doaj   +1 more source