Results 61 to 70 of about 48,643 (286)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Classical simulation of commuting quantum computations implies collapse of the polynomial hierarchy
, 2010 We consider quantum computations comprising only commuting gates, known as IQP computations, and provide compelling evidence that the task of sampling their output probability distributions is unlikely to be achievable by any efficient classical means ...
Aaronson S. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A Two-Process Model for Control of Legato Articulation Across a Wide Range of Tempos During Piano Performance [PDF]
, 1997 Prior reports indicated a non-linear increase in key overlap times (KOTs) as tempo slows for scales/arpeggios performed at internote intervals (INIs) of I00-1000 ms. Simulations illustrate that this function can be explained by a two-process model.
Bullock, Daniel, Jacobs, J. Pieter
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Energy‐efficient successive‐approximation‐register based capacitive interface for pressure sensors
Electronics Letters, 2015 A novel energy‐efficient 8 bit 2.78 kS/s capacitance‐to‐digital converter (CDC) interface for capacitive pressure sensors is presented. A new direct‐capacitance‐comparison technique (DCCT) is proposed and employed together with a successive approximation register (SAR) algorithm to resolve the sensor capacitance by, directly, comparing it with an on ...
A. Ismail, M. El‐Nafarawi
openaire +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
A Systematic Approach to Determining the Duty Cycle for Regenerative Comparator Used in WSN [PDF]
International Journal of Electronics and Telecommunications, 2019 A low power regenerative comparator is very useful in Successive Approximation Register (SAR) type Analog to Digital Converter (ADC) for a Wireless Sensor Node (WSN).
Dipak S. Marathe, Uday P. Khot
doaj +1 more source