Results 1 to 10 of about 218,507 (292)

Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention

Frontiers in Immunology
Succinate, traditionally viewed as a mere intermediate of the tricarboxylic acid (TCA) cycle, has emerged as a critical mediator in inflammation. Disruptions within the TCA cycle lead to an accumulation of succinate in the mitochondrial matrix.
Hong Huang, Gejing Li, Yini He, Jing Chen, Jianye Yan, Qin Zhang, Liqing Li, Liqing Li, Xiong Cai   +8 more
doaj   +2 more sources

Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets

Gut Microbes, 2022
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown.
Xihong Zhou, Yonghui Liu, Xia Xiong, Jingqing Chen, Wenjie Tang, Liuqin He, Zhigang Zhang, Yulong Yin, Fengna Li   +8 more
doaj   +2 more sources

Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages

Metabolites, 2020
Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vast ...
Karl J. Harber, Kyra E. de Goede, Sanne G. S. Verberk, Elisa Meinster, Helga E. de Vries, Michel van Weeghel, Menno P. J. de Winther, Jan Van den Bossche   +7 more
doaj   +2 more sources

Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish

Frontiers in Nutrition, 2022
Succinate is widely used in the food and feed industry as an acidulant, flavoring additive, and antimicrobial agent. This study investigated the effects of dietary succinate on growth, energy budget, nutritional metabolism, protein succinylation, and gut
Qianwen Ding, Qianwen Ding, Chenyao Lu, Qiang Hao, Qingshuang Zhang, Yalin Yang, Rolf Erik Olsen, Einar Ringo, Chao Ran, Zhen Zhang, Zhigang Zhou   +10 more
doaj   +2 more sources

Succinate in innate immunity: linking metabolic reprogramming to immune modulation [PDF]

Frontiers in Immunology
Succinate is an essential metabolite in the tricarboxylic acid (TCA) cycle. In mitochondria, succinate holds a unique position connecting the TCA cycle and the electron transport chain (ETC), thereby providing a shortcut path for adenosine triphosphate ...
Reham Atallah, Juergen Gindlhuber, Akos Heinemann   +2 more
doaj   +2 more sources

Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway [PDF]

Pediatric Discovery
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disorder that frequently affects premature infants, and its pathogenesis is closely related to macrophage polarization.
Sha Liu, Fang‐Ling Tang, Xiao‐Lin Yan, Xiao‐Chen Liu, Qing Ai, Lu‐Quan Li, Lei Bao   +6 more
doaj   +2 more sources

Flexible Thermal Sensitivity of Mitochondrial Oxygen Consumption and Substrate Oxidation in Flying Insect Species

Frontiers in Physiology, 2022
Mitochondria have been suggested to be paramount for temperature adaptation in insects. Considering the large range of environments colonized by this taxon, we hypothesized that species surviving large temperature changes would be those with the most ...
Hichem A. Menail, Hichem A. Menail, Simon B. Cormier, Simon B. Cormier, Mariem Ben Youssef, Lisa Bjerregaard Jørgensen, Jess L. Vickruck, Pier Morin, Luc H. Boudreau, Luc H. Boudreau, Nicolas Pichaud, Nicolas Pichaud   +11 more
doaj   +1 more source

Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish

Frontiers in Molecular Biosciences, 2021
Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang, Dai-xiao Yang, Dai-xiao Yang, Hao Yang, Hao Yang, Hao Yang, Yun-chao Cao, Yun-chao Cao, Yun-chao Cao, Ming Jiang, Ming Jiang, Ming Jiang, Jun Zheng, Bo Peng, Bo Peng, Bo Peng   +15 more
doaj   +1 more source

Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

Antioxidants, 2021
Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)—A specialised peripheral chemoreceptor.
Agnieszka Swiderska, Andrew M. Coney, Abdulaziz A. Alzahrani, Hayyaf S. Aldossary, Nikolaos Batis, Clare J. Ray, Prem Kumar, Andrew P. Holmes   +7 more
doaj   +1 more source

A Brief Review of Poly (Butylene Succinate) (PBS) and Its Main Copolymers: Synthesis, Blends, Composites, Biodegradability, and Applications

Polymers, 2022
PBS, an acronym for poly (butylene succinate), is an aliphatic polyester that is attracting increasing attention due to the possibility of bio-based production, as well as its balanced properties, enhanced processability, and excellent biodegradability ...
L. Aliotta, M. Seggiani, A. Lazzeri, V. Gigante, P. Cinelli   +4 more
semanticscholar   +1 more source