Results 1 to 10 of about 215,979 (293)

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

Cell Reports, 2021
Summary: Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate receptor SUCNR1. In the present study, we characterize and compare effects and signaling pathways
Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O’Callaghan, Thue W. Schwartz   +11 more
doaj   +2 more sources

Cellular succinate metabolism and signaling in inflammation: implications for therapeutic intervention

Frontiers in Immunology
Succinate, traditionally viewed as a mere intermediate of the tricarboxylic acid (TCA) cycle, has emerged as a critical mediator in inflammation. Disruptions within the TCA cycle lead to an accumulation of succinate in the mitochondrial matrix.
Hong Huang, Gejing Li, Yini He, Jing Chen, Jianye Yan, Qin Zhang, Liqing Li, Liqing Li, Xiong Cai   +8 more
doaj   +2 more sources

Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages

Metabolites, 2020
Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vast ...
Karl J. Harber, Kyra E. de Goede, Sanne G. S. Verberk, Elisa Meinster, Helga E. de Vries, Michel van Weeghel, Menno P. J. de Winther, Jan Van den Bossche   +7 more
doaj   +2 more sources

Succinate/IL-1β Signaling Axis Promotes the Inflammatory Progression of Endothelial and Exacerbates Atherosclerosis

Frontiers in Immunology, 2022
Inflammation is an important driver of atherosclerosis. Succinate is a new extracellular inflammatory alarm released by activated macrophages. Succinate is sensed by succinate receptor 1 (Sucnr1) and then transferred to effector cells.
Jingwen Xu, Yabing Zheng, Yaqing Zhao, Yujiao Zhang, Huilin Li, An Zhang, Xuehan Wang, Weizong Wang, Yinglong Hou, Jiangrong Wang   +9 more
doaj   +2 more sources

Flexible Thermal Sensitivity of Mitochondrial Oxygen Consumption and Substrate Oxidation in Flying Insect Species

Frontiers in Physiology, 2022
Mitochondria have been suggested to be paramount for temperature adaptation in insects. Considering the large range of environments colonized by this taxon, we hypothesized that species surviving large temperature changes would be those with the most ...
Hichem A. Menail, Hichem A. Menail, Simon B. Cormier, Simon B. Cormier, Mariem Ben Youssef, Lisa Bjerregaard Jørgensen, Jess L. Vickruck, Pier Morin, Luc H. Boudreau, Luc H. Boudreau, Nicolas Pichaud, Nicolas Pichaud   +11 more
doaj   +1 more source

Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish

Frontiers in Molecular Biosciences, 2021
Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang, Dai-xiao Yang, Dai-xiao Yang, Hao Yang, Hao Yang, Hao Yang, Yun-chao Cao, Yun-chao Cao, Yun-chao Cao, Ming Jiang, Ming Jiang, Ming Jiang, Jun Zheng, Bo Peng, Bo Peng, Bo Peng   +15 more
doaj   +1 more source

A Brief Review of Poly (Butylene Succinate) (PBS) and Its Main Copolymers: Synthesis, Blends, Composites, Biodegradability, and Applications

Polymers, 2022
PBS, an acronym for poly (butylene succinate), is an aliphatic polyester that is attracting increasing attention due to the possibility of bio-based production, as well as its balanced properties, enhanced processability, and excellent biodegradability ...
L. Aliotta, M. Seggiani, A. Lazzeri, V. Gigante, P. Cinelli   +4 more
semanticscholar   +1 more source

Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

Antioxidants, 2021
Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)—A specialised peripheral chemoreceptor.
Agnieszka Swiderska, Andrew M. Coney, Abdulaziz A. Alzahrani, Hayyaf S. Aldossary, Nikolaos Batis, Clare J. Ray, Prem Kumar, Andrew P. Holmes   +7 more
doaj   +1 more source

Succinate metabolism and its regulation of host-microbe interactions

Gut microbes, 2023
Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentration of succinate and inflammatory diseases caused by the overreaction of certain immune cells has become a research focus.
Yi Wei, Xi Ma, Jiangchao Zhao, Xiu-qi Wang, Chun-qi Gao   +4 more
semanticscholar   +1 more source

Crc Regulates Succinate-Mediated Repression of Mineral Phosphate Solubilization in Acinetobacter sp. SK2 by Modulating Membrane Glucose Dehydrogenase

Frontiers in Microbiology, 2021
The plant growth-promoting Acinetobacter sp. SK2 isolated from Vigna radiata rhizosphere was characterized for mineral phosphate solubilization (MPS).
Krishna Bharwad, Niharika Ghoghari, Shalini Rajkumar   +2 more
doaj   +1 more source