Results 21 to 30 of about 215,979 (293)

Succinate metabolism: a promising therapeutic target for inflammation, ischemia/reperfusion injury and cancer

Frontiers in Cell and Developmental Biology, 2023
Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA) cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing to energy production in fundamental mitochondrial metabolic pathways ...
Wenhui Zhang, Ren Lang
semanticscholar   +1 more source

Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels

Frontiers in Aging, 2022
Blue light (BL) is becoming increasingly prevalent in artificial illumination, raising concerns about its potential health hazard to humans. In fact, there is evidence suggesting that acute BL exposure may lead to oxidative stress and death of retinal ...
Jun Yang, Yujuan Song, Alexander D. Law, Conner J. Rogan, Kelsey Shimoda, Danijel Djukovic, Jeffrey C. Anderson, Doris Kretzschmar, David A. Hendrix, David A. Hendrix, Jadwiga M. Giebultowicz   +10 more
doaj   +1 more source

Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke

Redox Biology, 2023
Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury.
Amin Mottahedin, H. Prag, Andreas Dannhorn, R. Mair, C. Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J. Lee, N. Burger, D. Kulaveerasingam, Margaret M. Huang, S. Pluchino, L. Peruzzotti-Jametti, Richard Goodwin, C. Frezza, M. P. Murphy, T. Krieg   +16 more
semanticscholar   +1 more source

Succinate signaling attenuates high-fat diet-induced metabolic disturbance and intestinal barrier dysfunction.

Pharmacological Research, 2023
Succinate is a vital signaling metabolite produced by the host and gut microbiota. Succinate has been shown to regulate host metabolic homeostasis and inhibit obesity-associated inflammation in macrophages by engaging its cognate receptor, SUCNR1 ...
Xuan Li, Guowen Huang, Yanan Zhang, Yuting Ren, Ruofan Zhang, Weiyun Zhu, Kaifan Yu   +6 more
semanticscholar   +1 more source

The succinated proteome [PDF]

Mass Spectrometry Reviews, 2013
AbstractThe post‐translational modifications (PTMs) of cysteine residues include oxidation, S‐glutathionylation, S‐nitrosylation, and succination, all of which modify protein function or turnover in response to a changing intracellular redox environment.
Merkley, Eric D., Metz, Thomas O., Smith, Richard D., Baynes, John W., Frizzell, Norma   +4 more
openaire   +3 more sources

In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment

Journal of Integrative Bioinformatics, 2021
Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic ...
Man Mei Yen, Mohamad Mohd Saberi, Choon Yee Wen, Ismail Mohd Arfian   +3 more
doaj   +1 more source

Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets

Gut Microbes, 2022
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown.
Xihong Zhou, Yonghui Liu, Xia Xiong, Jingqing Chen, Wenjie Tang, Liuqin He, Zhigang Zhang, Yulong Yin, Fengna Li   +8 more
doaj   +1 more source

Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate

Microbiome, 2022
Succinate is produced by both human cells and by gut bacteria and couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate is elevated in patients with obesity and type 2 diabetes and is linked to numerous ...
Isabel Huber-Ruano, Enrique Calvo, J. Mayneris‐Perxachs, M-Mar Rodríguez-Peña, V. Ceperuelo-Mallafré, Lídia Cedó, C. Núñez-Roa, Joan Miro-Blanch, M. Arnoriaga-Rodríguez, Aurélie Balvay, Claire Maudet, P. García-Rovés, Oscar Yanes, Sylvie Rabot, G. Grimaud, A. De Prisco, A. Amoruso, J. Fernández-Real, J. Vendrell, Sonia Fernández-Veledo   +19 more
semanticscholar   +1 more source

Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo

Frontiers in Immunology, 2022
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects.
Tae Seok Oh, Damian C. Hutchins, Rabina Mainali, Kevin H. Goslen, Matthew A. Quinn, Matthew A. Quinn   +5 more
doaj   +1 more source

Nanofiltration of Succinic Acid in Strong Alkaline Conditions

Membranes, 2019
Nanofiltration is considered to be an appropriate separation technique in the production of bio-based materials. For the utilization of process streams from the viscose-fiber production, understanding the separation behavior of organic compounds in ...
Klaus Schlackl, Richard Herchl, Wolfgang Samhaber   +2 more
doaj   +1 more source