Results 21 to 30 of about 218,507 (292)

In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment

open access: yesJournal of Integrative Bioinformatics, 2021
Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic ...
Man Mei Yen   +3 more
doaj   +1 more source

Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo

open access: yesFrontiers in Immunology, 2022
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects.
Tae Seok Oh   +5 more
doaj   +1 more source

Nanofiltration of Succinic Acid in Strong Alkaline Conditions

open access: yesMembranes, 2019
Nanofiltration is considered to be an appropriate separation technique in the production of bio-based materials. For the utilization of process streams from the viscose-fiber production, understanding the separation behavior of organic compounds in ...
Klaus Schlackl   +2 more
doaj   +1 more source

Cancer-derived extracellular succinate: a driver of cancer metastasis

open access: yesJournal of Biomedical Sciences, 2022
Succinate is a tricarboxylic acid (TCA) cycle intermediate normally confined to the mitochondrial matrix. It is a substrate of succinate dehydrogenase (SDH). Mutation of SDH subunits (SDHD and SDHB) in hereditary tumors such as paraganglioma or reduction
C. Kuo, Jing-Yiing Wu, Kenneth K. Wu
semanticscholar   +1 more source

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

open access: yesNature, 2014
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and stroke.
Edward T. Chouchani   +28 more
semanticscholar   +1 more source

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

open access: yesNature Communications, 2021
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear.
Xiao-Hui Wang   +12 more
semanticscholar   +1 more source

Multi-Omics Unravels Metabolic Alterations in the Ileal Mucosa of Neonatal Piglets Receiving Total Parenteral Nutrition

open access: yesMetabolites, 2023
Total parenteral nutrition (TPN) is life-saving therapy for the pediatric patients with intestinal failure (IF) who cannot tolerate enteral nutrition (EN).
Junkai Yan   +4 more
doaj   +1 more source

Mitochondrial respiration after combined action of dehydration and low temperature in pea seedlings

open access: yesBiologia Plantarum, 2019
The impact of the individual and combined action of dehydration and low temperature on the respiratory activity of mitochondria isolated from epicotyls of pea (Pisum sativum L.) seedlings was investigated. These organelles were isolated immediately after
I.P. Generozova   +2 more
doaj   +1 more source

Tetrahydrocurcumin Derivatives Enhanced the Anti-Inflammatory Activity of Curcumin: Synthesis, Biological Evaluation, and Structure–Activity Relationship Analysis

open access: yesMolecules, 2023
Tetrahydrocurcumin, the most abundant curcumin transformation product in biological systems, can potentially be a new alternative therapeutic agent with improved anti-inflammatory activity and higher bioavailability than curcumin.
Yisett González   +8 more
doaj   +1 more source

Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

open access: yesBiomedicines, 2022
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism.
Paule Bénit   +6 more
doaj   +1 more source

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