Results 21 to 30 of about 426,215 (376)

Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas

Frontiers in Endocrinology, 2021
Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative.
Dieter M. Matlac, Katerina Hadrava Vanova, Nicole Bechmann, S. Richter, J. Folberth, H. Ghayee, Guangbo Ge, Luma Abunimer, R. Wesley, R. Aherrahrou, Margo Dona, Á. Martínez-Montes, Bruna Calsina, M. Merino, M. Schwaninger, P. Deen, Z. Zhuang, J. Neuzil, K. Pacak, H. Lehnert, S. Fliedner   +20 more
semanticscholar   +1 more source

The Synthesis of Succinate‐Dehydrogenase Riboflavin [PDF]

Angewandte Chemie International Edition in English, 1970
Singer and Kearney"], in their early studies, recognized that the flavocoenzyme of mitochondria1 succinate dehydrogenase ("SD-flavin") [**I was a derivative of flavin-adenine-dinucleotide which was covalently bound to the protein. In cooperation with Dr. Singer's team [***I, we have attempted to elucidate the structure of this coenzyme.
Ghisla, Sandro, Hartmann, Ursula, Hemmerich, Peter   +2 more
openaire   +4 more sources

On the need for regulation of succinate dehydrogenase [PDF]

FEBS Letters, 1971
It has been known since 1955 that substrates and competitive inhibitors of succinate dehydrogenase activate the enzyme by a process which is believed to involve a conformation change in the enzyme [ 1, 21. The activation is completely reversible, since on removal of the substrate the activated enzyme rapidly reverts to the unactivated (inactive) form ...
Thomas P. Singer, Thomas P. Singer, M. Gutman, M. Gutman, Edna B. Kearney, Edna B. Kearney   +5 more
openaire   +3 more sources

The Effect of Initial Moisture Content, Packaging and Storage Period on Succinate Dehydrogenase and Cytochrome Oxidase Activity of Soybean Seed

Biotropia: The Southeast Asian Journal of Tropical Biology, 2010
The quality of soybean seed is easily decreased, so that it is difficult to keep them for a long time. The research aims to study the effect of initial moisture content, packaging material and storage period on succinate dehydrogenase and cytochrome ...
Aurellia Tatipata
doaj   +3 more sources

Expedient Discovery for Novel Antifungal Leads Targeting Succinate Dehydrogenase: Pyrazole-4-formylhydrazide Derivatives Bearing a Diphenyl Ether Fragment.

Journal of Agricultural and Food Chemistry, 2020
The pyrazole-4-carboxamide scaffold containing a flexible amide chain has emerged as the molecular skeleton of highly efficient agricultural fungicides targeting succinate dehydrogenase (SDH).
Xiaobin Wang, An Wang, Ling-Ling Qiu, Min Chen, Ai-min Lu, Guohua Li, Chunlong Yang, Wei Xue   +7 more
semanticscholar   +1 more source

Functional and Biogenetical Heterogeneity of the Inner Membrane of Rat-Liver Mitochondria [PDF]

, 1971
Rat liver mitochondria were fragmented by a combined technique of swelling, shrinking, and sonication. Fragments of inner membrane were separated by density gradient centrifugation.
Allmann D. W., Ashwell M., Beattie D. S., Beattie D. S., Brunner G., Burstone M. S., Davis K. A., Delbruck A., Fiske C. H., Folch J., Gear A. R. L., Gear A. R. L., Gear A. R. L., Gelder B. F., Gotterer G. S., Hasegawa E., Hawley E. S., Johnson A. B., Klingenberg M., Kuntzel H., Labbe R. F., Lentz P. E., Neupert W., Neupert W., Novikoff A. B., Ohnishi K., Omura T., Parsons D. F., Parsons D. F., Pette D., Pollak J. K., Pullmann M. E., Raw J., Raw J., Reith A., Schneider W. C., Schuel H., Schumacher H.-H., Sebald W., Sebald W., Seligman A. M., Sies H., Sottocasa G. L., Stoffel W., Strecker H. J., Swick R. W., Szarkowska L., Tabor C. W., Tol A., Vazquez J. J., Yonetani T.   +50 more
core   +1 more source

Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. [PDF]

PLoS Pathogens, 2014
In chronic infection, Mycobacterium tuberculosis bacilli are thought to enter a metabolic program that provides sufficient energy for maintenance of the protonmotive force, but is insufficient to meet the demands of cellular growth.
Travis Hartman, Brian Weinrick, Catherine Vilchèze, Michael Berney, Joanne Tufariello, Gregory M Cook, William R Jacobs   +6 more
doaj   +1 more source

Treatment responses to antiangiogenetic therapy and chemotherapy in nonsecreting paraganglioma (PGL4) of urinary bladder with SDHB mutation: a case report [PDF]

, 2018
Paraganglioma (PGL) is a rare neuroendocrine tumor. Currently, the malignancy is defined as the presence of metastatic spread at presentation or during follow-up.
Aschelter, Am, Capriotti, G, Cerquetti, L, Lardo, P, Marchetti, P, Matarazzo, I, Nardone, Mr, Petrangeli, E, Schiavi, F, Stigliano, A, Toscano, V   +10 more
core   +1 more source

Itaconate and Its Derivatives Repress Early Myogenesis In Vitro and In Vivo

Frontiers in Immunology, 2022
A Krebs cycle intermediate metabolite, itaconate, has gained attention as a potential antimicrobial and autoimmune disease treatment due to its anti-inflammatory effects.
Tae Seok Oh, Damian C. Hutchins, Rabina Mainali, Kevin H. Goslen, Matthew A. Quinn, Matthew A. Quinn   +5 more
doaj   +1 more source

Transcriptional analysis of pqqD and study of the regulation of pyrroloquinoline quinone biosynthesis in Methylobacterium extorquens AM1 [PDF]

, 1995
Methanol dehydrogenase, the enzyme that oxidizes methanol to formaldehyde in gram-negative methylotrophs, contains the prosthetic group pyrroloquinoline quinone (PQQ).
Lidstrom, Mary E., Ramamoorthi, Roopa
core   +2 more sources