Results 51 to 60 of about 433,622 (361)

Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases

Cancers, 2020
Simple Summary Although the dysfunction of the succinate dehydrogenase complex in mitochondria leads to cancer and other diseases due to aberrant metabolic reactions and signaling pathways, it is not well known how the succinate dehydrogenase complex is ...
Cerena Moreno, Ruben Mercado Santos, R. Burns, Wen Cai Zhang   +3 more
semanticscholar   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Multistationary and Oscillatory Modes of Free Radicals Generation by the Mitochondrial Respiratory Chain Revealed by a Bifurcation Analysis [PDF]

, 2012
The mitochondrial electron transport chain transforms energy satisfying cellular demand and generates reactive oxygen species (ROS) that act as metabolic signals or destructive factors.
Mark F. Schumaker, Mark Friedman, Marta Cascante, Massimo Trucco, Philip E. Bourne, Tatyana V. Votyakova, Vitaly A. Selivanov   +6 more
core   +5 more sources

Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode

Pest Management Science, 2020
Succinate dehydrogenase inhibitors (SDHIs) have played a crucial role in disease control to protect cereals as well as fruit and vegetables for more than a decade.
P. Desbordes, B. Essigmann, S. Gary, Oliver Gutbrod, Michael Maue, Hans-Georg Schwarz   +5 more
semanticscholar   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene [PDF]

, 2001
The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential ...
Attardi, Giuseppe, Bai, Yidong, Chan, Elisa, Chomyn, Anne, Hájek, Petr, Matsuno-Yagi, Akemi, Seo, Byoung Boo, Yagi, Takao   +7 more
core   +1 more source

Cross-resistance in <i>Alternaria brassicicola</i> from naturally infested broccoli seeds against two succinate dehydrogenase inhibitor fungicides. [PDF]

Appl Environ Microbiol
Kaur N, Malik AA, Cerritos-Garcia DG, Koch Bach RA, Everhart S, Dutta B.   +5 more
europepmc   +2 more sources

A myzozoan-specific protein is an essential membrane-anchoring component of the succinate dehydrogenase complex in Toxoplasma parasites. [PDF]

Open Biol
Zwahlen SM, Hayward JA, Maguire CS, Qin AR, van Dooren GG.   +4 more
europepmc   +3 more sources

A novel mutation in the succinate dehydrogenase subunit D gene in siblings with the hereditary paraganglioma–pheochromocytoma syndrome

SAGE Open Medical Case Reports, 2014
Germline mutations in the succinate dehydrogenase complex subunit D gene are now known to be associated with hereditary paraganglioma–pheochromocytoma syndromes.
Chaithra Prasad, Gerard J Oakley, Linwah Yip, Christopher Coyne, Balasubramanya Rangaswamy, Sanjay B Dixit   +5 more
doaj   +1 more source

Inhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids [PDF]

, 2003
Copyright © 2003 Elsevier Ireland Ltd. All rights reserved.The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e ...
Arrabaça, João Daniel, Barreto, Maria do Carmo, Pavão, Maria Leonor, Pinto, Ruy Eugénio   +3 more
core   +1 more source