Results 71 to 80 of about 433,622 (361)

Succinate detection in glomus jugulare paraganglioma on MRS as a marker for SDHB mutation

Otolaryngology Case Reports, 2020
Succinate dehydrogenase gene mutation (SDH) is known as a cause of familial paraganglioma, and the dysfunction of SDH leads to the accumulation of succinate in the cell.
Shotaro Naganawa, Aristides A. Capizzano, Yoshiaki Ota, John Kim, Ashok Srinivasan, Toshio Moritani   +5 more
doaj   +1 more source

Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]

, 2018
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona, Barrett, Michael P., Goodyear, Carl S., Pountain, Andrew W., Rattigan, Kevin M., Regnault, Clement, Vincent, Isabel M.   +6 more
core   +3 more sources

The Synthesis of Succinate‐Dehydrogenase Riboflavin [PDF]

Angewandte Chemie International Edition in English, 1970
Singer and Kearney"], in their early studies, recognized that the flavocoenzyme of mitochondria1 succinate dehydrogenase ("SD-flavin") [**I was a derivative of flavin-adenine-dinucleotide which was covalently bound to the protein. In cooperation with Dr. Singer's team [***I, we have attempted to elucidate the structure of this coenzyme.
Ghisla, Sandro, Hartmann, Ursula, Hemmerich, Peter   +2 more
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Succinate Dehydrogenase–Deficient Paraganglioma of the Prostate

Annals of Internal Medicine: Clinical Cases, 2023
Paragangliomas emerging in unusual locations may represent a diagnostic pitfall. We report clinical, genetic, imaging, and histopathologic features of succinate dehydrogenase–deficient paraganglioma arising within the prostate gland.
Gabriela Szuman, Lama Amer, Robert Hamilton, Ur Metser, Sylvia L. Asa, Ozgur Mete, Shereen Ezzat   +6 more
doaj   +1 more source

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression [PDF]

, 2018
The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated.
Avolio, Carlo, Bellanti, Francesco, Blonda, Maria, di Bello, Giorgia, Facciorusso, Antonio, Iannelli, Giuseppina, Iuliano, Luigi, Poli, Giuseppe, Serviddio, Gaetano, Tamborra, Rosanna, Vendemiale, Gianluigi, Villani, Rosanna   +11 more
core   +2 more sources

A highly malignant succinate dehydrogenase A‑deficient renal cell carcinoma with bone metastasis misdiagnosed as hereditary leiomyomatosis and renal cell carcinoma: A case report. [PDF]

Oncol Lett
Dai Z, Wang X, Zhang Y, Qiu Y, Liu J.
europepmc   +3 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

Nature Communications
A prevalent side-reaction of succinate dehydrogenase oxidizes malate to enol-oxaloacetate (OAA), a metabolically inactive form of OAA that is a strong inhibitor of succinate dehydrogenase. We purified from cow heart mitochondria an enzyme (OAT1) with OAA
Anthony J. Zmuda, Xiaojun Kang, Katie B. Wissbroecker, Katrina Freund Saxhaug, Kyle C. Costa, Adrian D. Hegeman, Thomas D. Niehaus   +6 more
doaj   +1 more source

Trace-gas metabolic versatility of the facultative methanotroph Methylocella silvestris [PDF]

, 2014
The climate-active gas methane is generated both by biological processes and by thermogenic decomposition of fossil organic material, which forms methane and short-chain alkanes, principally ethane, propane and butane1, 2. In addition to natural sources,
A Crombie, AR Theisen, B Gilbert, C Anthony, CJ Marx, CM Reddy, D Mackay, EL Johnson, FD Mango, G Etiope, G Etiope, G Etiope, G Etiope, H Barrios, IR McDonald, J Colby, J Heider, J Sambrook, JD Semrau, JG Leahy, K Tamura, KU Hinrichs, MJ Green, MT Rahman, N Hamamura, NA Patel, NV Coleman, NV Coleman, OU Mason, P Guerlava, RB Cooley, SD Prior, SG Osborn, SN Dedysh, T Furuya, T Kotani, T Kotani, VJ Patel, W Ashraf, WS Reeburgh, Y Chen   +40 more
core   +1 more source