Results 61 to 70 of about 3,444 (280)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling

Acta Societatis Botanicorum Poloniae, 2017
Tree saps are nourishing biological media commonly used for beverage and syrup production. Although the nutritional aspect of tree saps is widely acknowledged, the exact relationship between the sap composition, origin, and effect on the metabolic rate ...
Artur Wnorowski, Maciej Bilek, Kinga Stawarczyk, Michał Gostkowski, Marcin Olszewski, Magdalena Wójciak-Kosior, Ireneusz Sowa   +6 more
doaj   +1 more source

Interactions between hydrated cement paste and organic acids: Thermodynamic data and speciation modeling

, 2015
International audienceInteractions of short-chain organic acids with hydrated cement phases affect structure durability in the agro-food and nuclear waste industries but can also be used to modify cement properties.
Bertron, Alexandra, de Windt, Laurent, Escadeillas, Gilles, Larreur-Cayol, S.   +3 more
core   +3 more sources

Squarate desymmetrisation–ozonolysis as an approach to β-substituted-α-ketosuccinates and squalestatin synthesis [PDF]

, 2019
Silylated tertiary alcohols from 1,2-addition of alkyllithiums to dialkyl squarates undergo alkene ozonolysis to give β-substituted-α-keto-β-(silyloxy)succinates. With 3-(triethylsilyloxy)butyllithium the methodology was applied to the 2,8-dioxabicyclo[3.
Harling, DC, Hodgson, David, Sintim, HO, Valade, A   +3 more
core   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Production of dicarboxylic acid platform chemicals using yeasts: focus on succinic acid [PDF]

, 2016
The biotechnological production of biobased dicarboxylic acids has recently become a hot topic in industrial biotechnology, with many investments involved in the development, piloting, and validation at demonstration scale of diverse processes using ...
Carolas, Ana, Ferreira, Bruno Sommer, Figueira, Diogo, Franco-Duarte, Ricardo, Pais, Célia, Sampaio, Paula, Wildner, Jessica   +6 more
core   +1 more source

Robust and Reversible Thermofluorescence in Solvent‐Free Thermoplastic Polyurethane Composites

Advanced Functional Materials, EarlyView.
Thermofluorescent polymer composites with high‐contrast optical outputs are prepared by solvent‐free blending of indenoquinacridone dye into a thermoplastic polyurethane matrix. The temperature‐dependent fluorescence originates from aggregation–dissociation of the dye molecules, regulated by competing hydrogen bonds from the polymer matrix.
Guanghua Yu, Bowen Tian, Jazmine Aiya Marquez, Chia‐Min Hsieh, Qingsheng Wang, Hung‐Jue Sue, Mohammed Al‐Hashimi, Peiran Wei, Lei Fang   +8 more
wiley   +1 more source

Effects of Molecular Designs and Double‐Network Morphologies for Bioadhesive Semiconductors

Advanced Functional Materials, EarlyView.
This study establishes molecular‐to‐mesoscale design rules for bioadhesive semiconducting polymers (BASCs). It identifies how side‐chain length, double‐network formation, and film thickness modulate adhesion strength and electronic performance, providing insight into the rational design of intrinsically adhesive semiconductors for stable and efficient ...
Zhichang Liu, Nan Li, Yuqing Chen, Naisong Shan, Shinya Wai, Jie‐Hao Chen, Aidan Ziaja, Shrayesh N. Patel, Sihong Wang   +8 more
wiley   +1 more source

Cobalt(II) and copper(II) complexes with carboxylic acids, imidazole, and 2-methylimidazole [PDF]

, 2015
The compositions of [MIm(MeIm)x]L complexes synthesized by the reaction of cobalt(II) and copper(II) fumarates ML · nH2O with imidazole (Im) and 2-methylimidazole (MeIm) were determined.
Bukholtseva, E. I., Filippova, M. M., Kurzina, Irina A., Malkov, Victor S., Skorik, N. A.   +4 more
core   +2 more sources