Decoding the regulatory networks of Proteus mirabilis under succinic acid stress: a multi-omics approach [PDF]
Frontiers in Cellular and Infection MicrobiologyProteus mirabilis, a major catheter-associated urinary tract infection pathogen, forms antibiotic-resistant crystalline biofilms. Our study demonstrates succinic acid’s multimodal inhibition of P.mirabilis via multi-omics analyses.
Aoyu Yang +9 more
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Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
Pharmaceutical Biology, 2020 Context Succinic acid, extracted from amber, is widely used in cardiovascular therapy. Objective The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study.
Hao Wang +5 more
doaj +2 more sources
Succinic acid improves crop chemical components by regulating soil chemical properties, microbes and metabolites [PDF]
Frontiers in MicrobiologyIntroductionSmall molecule metabolites can act as soil conditioners to improve the soil environment and thereby promote crop growth. Like many other components of root exudates, succinic acid not only contributes to plant growth and stress resistance but
Dian-long Li +9 more
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Succinic Acid: Technology Development and Commercialization
Fermentation, 2017 Succinic acid is a precursor of many important, large-volume industrial chemicals and consumer products. It was once common knowledge that many ruminant microorganisms accumulated succinic acid under anaerobic conditions.
Nhuan P. Nghiem +2 more
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Mechanistic Insights into Succinic Acid as an Adjuvant for Ciprofloxacin in Treating Pseudomonas aeruginosa Growing Within Cystic Fibrosis Airway Mucus [PDF]
MicroorganismsPseudomonas aeruginosa is a major cause of chronic respiratory infections in patients with cystic fibrosis (CF), with biofilm formation contributing to its persistence and antibiotic resistance.
Rosana Monteiro +3 more
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BMC Complementary and Alternative Medicine, 2019 Background Baltic amber teething necklaces have been popularized as a safe and natural alternative to conventional or pharmacological medicines for the management of teething pain. However, claims made by retailers regarding the efficacy and mechanism of
Michael D. Nissen +3 more
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Exploring the mechanism of action of succinic acid in ovarian cancer via single-cell sequencing of the tumor immune microenvironment [PDF]
Frontiers in OncologyBackgroundThe main treatments for ovarian cancer are surgery, chemotherapy, radiotherapy, and targeted therapy. Targeted therapy is a new treatment method that has emerged in recent years and relies on specific molecular targets to treat cancer. Succinic
Jiao Zhao +3 more
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Polymorphism manifestations and aqueous environment influence on the physico-chemical properties of modified succinic acid [PDF]
Известия Саратовского университета. Новая серия: Физика, 2022 Background and Objectives: Succinic acid is widely used in medicine, in particular, in the treatment of cardiological, neurological and endocrinological diseases.
Plastun, Inna L'vovna +3 more
doaj +1 more source
Nature Communications, 2023 Succinic acid (SA) is an important C4-dicarboxylic acid. Microbial production of SA at low pH results in low purification costs and hence good overall process economics.
Zhiyong Cui +8 more
semanticscholar +1 more source
bioRxiv, 2023 As one of the top value-added chemicals, succinic acid has been the focus of numerous metabolic engineering campaigns since the 1990s. However, microbial production of succinic acid at an industrially relevant scale has been hindered by high downstream ...
V. Tran +12 more
semanticscholar +1 more source