Results 111 to 120 of about 7,622 (205)

SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia

Cell Reports
Summary: Mitochondria-driven histone lysine succinylation is emerging as a critical signaling system that links cellular metabolism to the pathogenesis of diseases, including cancer. Here, we report that a global increase in protein/histone succinylation
Mengqing Gao, Minhui Shi, Hao Ding, Lei Xu, Na Zhao, Li Wang, Shujuan Huang, Hui Jiang, Ekaterina Bourova-Flin, Jianqing Mi, Saadi Khochbin, Domenico Iuso, Xiaoyu Zhu   +12 more
doaj   +1 more source

No wisdom in the crowd: genome annotation at the time of big data - current status and future prospects [PDF]

, 2018
Science and engineering rely on the accumulation and dissemination of knowledge to make discoveries and create new designs. Discovery-driven genome research rests on knowledge passed on via gene annotations.
Danchin, Antoine
core  

Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation

Nature Communications
Gemcitabine combined with cisplatin is the first-line chemotherapy for advanced cholangiocarcinoma, but drug resistance remains a challenge, leading to unsatisfactory therapeutic effect.
Ning Zhang, Linmao Sun, Shuo Zhou, Changyong Ji, Tianming Cui, Qi Chu, Jiareng Ye, Shuhang Liang, Kun Ma, Yufeng Liu, Xianying Li, Xinyu Guo, Weizhi Zhang, Xuetian Gu, Cheng Cheng, Qingrui Zha, Shengwei Tao, Yunguang Zhang, Junhui Chu, Chenghui Wu, Yuchen Zhang, Jiabei Wang, Yao Liu, Lianxin Liu   +23 more
doaj   +1 more source

Potential for utilization of algal biomass for components of the diet in CELSS [PDF]

The major nutritional components of the green algae (Scenedesmus obliquus) grown in a Constant Cell Density Apparatus were determined. Suitable methodology to prepare proteins from which three major undesirable components of these cells (i.e., cell walls,
Kamarei, A. R., Karel, M., Nakhost, Z.
core   +1 more source

Lipophilisation des protéines biocatalysées par des lipases : cas des isolats de protéines de soja [PDF]

, 1997
La lipophilisation par biocatalyse a été effectuée sur des isolats de protéines de soja, riches en lysine. Les réactions ont été conduites à 60 degrés C avec et sans solvant en mettant en oeuvre une lipase fixée (lipozyme) ou libre (lipase S de Rhizopus ...
Graille, Jean, Huc, Alain, Perrier, Eric, Pina, Michel, Roussel, Coralie   +4 more
core  

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

Cell Reports
Summary: Tank-binding kinase 1 (TBK1) is a critical signal transducer in the nuclear factor κB (NF-κB) and interferon regulatory factor (IRF) pathways, essential for innate immunity. However, its negative regulation mechanisms remain unclear.
Xuedi Zhang, Chunxiu Ling, Ziying Xiong, Ting Gong, Shuhua Luo, Xiaolei Liu, Lina Zhang, Chaoxiong Liao, Yue Lu, Xiao Huang, Wending Zhou, Shuangnan Zhou, Youtan Liu, Jing Tang   +13 more
doaj   +1 more source

HAMAP in 2015: updates to the protein family classification and annotation system [PDF]

, 2017
HAMAP (High-quality Automated and Manual Annotation of Proteins—available at http://hamap.expasy.org/) is a system for the automatic classification and annotation of protein sequences. HAMAP provides annotation of the same quality and detail as UniProtKB/
Auchincloss, Andrea H., Baratin, Delphine, Bougueleret, Lydie, Bridge, Alan, Coudert, Elisabeth, Cuche, Béatrice A., deCastro, Edouard, Keller, Guillaume, Pedruzzi, Ivo, Poux, Sylvain, Redaschi, Nicole, Rivoire, Catherine, Xenarios, Ioannis   +12 more
core  

Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation [PDF]

Cell Discovery, 2018
Wang, Yugang, Guo, Yusong R., Xing, Dongming, Tao, Yizhi Jane, Lu, Zhimin   +4 more
openaire   +3 more sources

Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism

Journal of Neuroinflammation
The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life.
Xinnan Zhao, Xiaohan Yang, Cong Du, Huimin Hao, Shuang Liu, Gang Liu, Guangyin Zhang, Kai Fan, Jianmei Ma   +8 more
doaj   +1 more source

Succinyl-coenzyme A: a key metabolite and succinyl group donor in erythropoiesis

Haematologica
Not available.
openaire   +3 more sources