Results 91 to 100 of about 6,092 (196)

Lysine Succinylation and Lysine Malonylation in Histones

Molecular & Cellular Proteomics, 2012
Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified by MS/MS of synthetic peptides, HPLC co-elution, and isotopic labeling.
Zhongyu, Xie, Junbiao, Dai, Lunzhi, Dai, Minjia, Tan, Zhongyi, Cheng, Yeming, Wu, Jef D, Boeke, Yingming, Zhao   +7 more
openaire   +2 more sources

Effect of succinylation on the oligometric structure of glycinin.

, 1979
By varying the ratio of succinic anhydride to the protein, glycinin, one of the major fractions of soybean proteins, is succinylated to various levels.
Appu Rao, A. G., Narasinga Rao, M. S.
core   +1 more source

Succinyl Choline

نشریه پرستاری ایران, 1998
This is an associational research which was conducted to evaluate the correlation between plasma level of pseudocholinesterase and duration of succinylcholine induced apnea in patients undergoing general anesthesia in one of the hospitals of Iran medical Sciences University in 1993.
openaire   +1 more source

Influence of added amounts of succinic anhydride on the succinylation lebel for some proteins

, 1997
The relationship between the added amount of succinic anhydride (SA) and the succinylation level of five sample proteins was examined to clarify some effective functions to control the succinylation level.
甲斐, 徳久, Tanoue, Yasuhiro, タノウエ, ヤスヒロ, 永井, 毅, Hamada, Moritsugu, ハマダ, モリツグ, 2865, 浜田, 盛承, Kai, Norihisa, 2863, 田上, 保博, Nagai, Takeshi, 2939, ナガイ, タケシ, カイ, ノリヒサ, 2945   +15 more
core  

SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1

Gynecological Endocrinology
Polycystic ovarian syndrome (PCOS) is a major cause of infertility. Succinylation is involved in disease processes; however, its role in PCOS remains unknown.
Yiwen Zhang, Fangfang He, Ning Cai, Guanmei Chen, Yinyin Wang, Weiwei Bai, Peng Guo   +6 more
doaj   +1 more source

Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism

Journal of Neuroinflammation
The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life.
Xinnan Zhao, Xiaohan Yang, Cong Du, Huimin Hao, Shuang Liu, Gang Liu, Guangyin Zhang, Kai Fan, Jianmei Ma   +8 more
doaj   +1 more source

Influences of different dissolving method of succinic anhydride on the succinylation level of some proteins

, 1999
The influences of different dissolving methods of succinic anhydride (SA) were examined in the succinylation for some proteins. Sample proteins were BSA, casein, egg white albumin, and myofibrillar proteins and sarcoplasmic proteins obtained from fish ...
甲斐, 徳久, Tanoue, Yasuhiro, タノウエ, ヤスヒロ, 永井, 毅, Hamada, Moritsugu, ハマダ, モリツグ, 2865, 浜田, 盛承, Kai, Norihisa, 2863, 田上, 保博, Nagai, Takeshi, 2939, ナガイ, タケシ, カイ, ノリヒサ, 2945   +15 more
core  

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma

Signal Transduction and Targeted Therapy
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized. In this study,
Jun Wu, Jingsheng Yuan, Zijian Liu, Yongjie Zhou, Bo Zhang, Yahong Xu, Qiwen Zeng, Zhenru Wu, Lingxiang Kong, Jiaguo Wang, Bohan Zhang, Jian Yang, Tao Lv, Yujun Shi, Jiayin Yang   +14 more
doaj   +1 more source

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis

Cell Reports
Summary: Tank-binding kinase 1 (TBK1) is a critical signal transducer in the nuclear factor κB (NF-κB) and interferon regulatory factor (IRF) pathways, essential for innate immunity. However, its negative regulation mechanisms remain unclear.
Xuedi Zhang, Chunxiu Ling, Ziying Xiong, Ting Gong, Shuhua Luo, Xiaolei Liu, Lina Zhang, Chaoxiong Liao, Yue Lu, Xiao Huang, Wending Zhou, Shuangnan Zhou, Youtan Liu, Jing Tang   +13 more
doaj   +1 more source

Impact of Lysine Succinylation on the Biology of Fungi

Current Issues in Molecular Biology
Post-translational modifications (PTMs) play a crucial role in protein functionality and the control of various cellular processes and secondary metabolites (SMs) in fungi. Lysine succinylation (Ksuc) is an emerging protein PTM characterized by the addition of a succinyl group to a lysine residue, which induces substantial alteration in the chemical ...
John Adejor, Elisabeth Tumukunde, Guoqi Li, Hong Lin, Rui Xie, Shihua Wang   +5 more
openaire   +3 more sources