Results 71 to 80 of about 6,092 (196)

Identification of Lysine Succinylation Substrates and the Succinylation Regulatory Enzyme CobB in Escherichia coli

Molecular & Cellular Proteomics, 2013
Lysine succinylation is a newly identified protein post-translational modification pathway present in both prokaryotic and eukaryotic cells. However, succinylation substrates and regulatory enzyme(s) remain largely unknown, hindering the biological study of this modification.
Gozde, Colak, Zhongyu, Xie, Anita Y, Zhu, Lunzhi, Dai, Zhike, Lu, Yi, Zhang, Xuelian, Wan, Yue, Chen, Yoon H, Cha, Hening, Lin, Yingming, Zhao, Minjia, Tan   +11 more
openaire   +2 more sources

Proteome-wide analyses reveal diverse functions of protein acetylation and succinylation modifications in fast growing stolons of bermudagrass (Cynodon dactylon L.)

BMC Plant Biology, 2022
Background Bermudagrass (Cynodon dactylon L.) is an important warm-season turfgrass species with well-developed stolons, which lay the foundation for the fast propagation of bermudagrass plants through asexual clonal growth.
Bing Zhang, Zhuoting Chen, Qixue Sun, Jianxiu Liu   +3 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. [PDF]

, 2020
Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial encephalomyopathy of unknown pathomechanism.
He, W, Carroll, Christopher J., Euro, L, Parisi, Alice, He, Wenjuan, Euro, Liliya, Moco, Sofia, Suomalainen, A, Verdin, E, Nishida, Y, Christen, Stefan, Locasale, Jason W., Carroll, CJ, Østergaard, E, Thevenet, J, Richard, Joy, Meyer, JG, Pällijeff, P, Richard, J, Isohanni, Pirjo, Østergaard, Elsebet, Gut, P, Isohanni, P, Newman, John C., Newman, JC, Liu, Xiaojing, Moco, S, Ostergaard, Elsebet, Minassian, BA, Pallijeff, Pieti, Liu, X, Parisi, A, Alkhater, RA, Alkhater, Reem A., Locasale, JW, Schilling, Birgit, Meyer, Jesse G., Nishida, Yuya, Rardin, MJ, Minassian, Berge A., Verdin, Eric, Jackson, Christopher B., Thevenet, Jonathan, Civiletto, G, Schilling, B, Civiletto, Gabriele, Gut, Philipp, Suomalainen, Anu, Matilainen, Sanna, Jackson, CB, Rardin, Matthew J., Matilainen, S, Christen, S   +52 more
core   +1 more source

Homo‐/Heterodimeric Substrates Bias the Type and Multiplicity of Hydroxamic Acid Chelators Assembled by a NIS Synthetase DesD

Chemistry – A European Journal, Volume 32, Issue 32, 24 August 2026.
Chemoenzymatic reactions using the siderophore synthetase DesD from Salinispora tropica and hydroxamic acid substrates (native, non‐native) with different multiplicities (monomer, dimer) and components (homo‐/heterodimer) followed different reaction trajectories, which biased the architectures of the chelator major products and indicated DesD contains ...
Callum A. Rosser, Todd E. Markham, Rachel Codd   +2 more
wiley   +1 more source

First Succinyl-Proteome Profiling of Extensively Drug-Resistant Mycobacterium tuberculosis Revealed Involvement of Succinylation in Cellular Physiology

, 2016
Protein lysine succinylation, an emerging protein post-translational modification widespread among eukaryotic and prokaryotic cells, represents an important regulator of cellular processes.
Qinqin Huang (1696423), Longxiang Xie (1696417), Qiming Li (1466779), Mengmeng Xu (1696420), Mingliang Zhou (172233), Shudan Chen (341235), Jianping Xie (550373), Jie Zeng (315334), Wei Liu (20030)   +8 more
core   +2 more sources

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Regulation of urea cycle by reversible high-stoichiometry lysine succinylation

The post-translational modification lysine succinylation is implicated in the regulation of various metabolic pathways. However, its biological relevance remains uncertain due to methodological difficulties in determining high-impact succinylation sites.
Kwok, Ryan, Zhang, Ran, Xie, Xueshu, Wei, Lei, Bons, Joanna, Carrico, Chris, Rose, Jacob, Schilling, Birgit, Meyer, Jesse G., Riley, Rebeccah, Kumaar, Prasanna Vadhana Ashok, He, Wenjuan, Nishida, Yuya, Fang, Jingqi, Verdin, Eric, Locasale, Jason W., Zhang, Yini, Liu, Xiaojing   +17 more
core   +1 more source

Quantitative Succinyl-Proteome Profiling of Camellia sinensis cv. ‘Anji Baicha’ During Periodic Albinism

Scientific Reports, 2017
Lysine succinylation is a novel dynamic and evolutionarily conserved post-translational modification (PTM) that regulates various biological processes. ‘Anji Baicha’ is an albino tea variety that exhibits temperature-based variability of leaf colour and ...
Yan-Xia Xu, Chen-Jia Shen, Jian-Qiang Ma, Wei Chen, Juan Mao, Yan-Yan Zhou, Liang Chen   +6 more
doaj   +1 more source

Comprehensive analysis of the succinylome in Vero cells infected with peste des petits ruminants virus Nigeria 75/1 vaccine strain

BMC Veterinary Research
Background Peste des petits ruminants virus (PPRV) is currently the only member of the Morbillivirus caprinae species within the genus Morbillivirus of the family Paramyoxviridae.
Xuelian Meng, Xueliang Zhu, Xiangwei Wang, Rui Zhang, Zhidong Zhang, Yuefeng Sun   +5 more
doaj   +1 more source