Results 141 to 147 of about 587 (147)

Quantitative Dynamics of Proteome, Acetylome, and Succinylome during Stem-Cell Differentiation into Hepatocyte-like Cells

Journal of Proteome Research, 2018
Stem-cell differentiation is a complex biological process controlled by a series of functional protein clusters and signaling transductions, especially metabolism-related pathways. Although previous studies have quantified the proteome and phosphoproteome for stem-cell differentiation, the investigation of acylation-mediated regulation is still absent.
Zekun Liu, Qing-bin Zhang, Chen Bu, Dawei Wang, Kai Yu, Zhixue Gan, Jianfeng Chang, Zhongyi Cheng, Zexian Liu   +8 more
openaire   +2 more sources

Quantitative proteome and lysine succinylome analyses provide insights into metabolic regulation in breast cancer

Breast Cancer, 2018
Breast cancer, the most common invasive cancer and cause of cancer-related death in women worldwide, is a multifactorial, complex disease, and many molecular players and mechanisms underlying the complexity of its clinical behavior remain unknown.To explore the molecular features of breast cancer, quantitative proteome and succinylome analyses in ...
Chenchen, Liu, Ying, Liu, Lei, Chen, Mingjun, Zhang, Wei, Li, Huaidong, Cheng, Bo, Zhang   +6 more
openaire   +2 more sources

Lysine succinylome analysis of MRSA reveals critical roles in energy metabolism and virulence

Letters in Applied Microbiology
Abstract Methicillin-resistant Staphylococcus aureus’s (MRSA) resistance poses a global health challenge. This study investigates lysine succinylation in MRSA using proteomics and bioinformatics approaches to uncover metabolic and virulence mechanisms, with the goal of identifying novel therapeutic targets.
Xiangqin, Zhu, Hui, Min, Yishan, Tang, Min, Gao   +3 more
openaire   +2 more sources

Systematic identification of mitochondrial lysine succinylome in silkworm ( Bombyx mori ) midgut during the larval gluttonous stage

Journal of Proteomics, 2018
Lysine succinylation is a newly identified protein post-translational modification (PTM) of lysine residues. Increasing evidences demonstrate that this modification is prevalent in mitochondria and regulates many vital cellular processes, especially metabolism. Here, we determined the succinylome of the silkworm (Bombyx mori) midgut mitochondria during
Jine, Chen, Fengbo, Li, Yan, Liu, Weifeng, Shen, Xin, Du, Lihua, He, Zhiqi, Meng, Xianliang, Ma, Yongqiang, Wang   +8 more
openaire   +2 more sources

Succinylome Analysis Reveals the Involvement of Lysine Succinylation in the Extreme Resistance of Deinococcus radiodurans

PROTEOMICS, 2019
AbstractIncreasing evidence shows that the succinylation of lysine residues mainly regulates enzymes involved in the carbon metabolism pathway, in both prokaryotic and eukaryotic cells. Deinococcus radiodurans is one of the most radioresistant organisms on earth and is famous for its robust resistance.
Congli Zhou, Jingli Dai, Huizhi Lu, Zijing Chen, Miao Guo, Yuan He, Kaixuan Gao, Tong Ge, Jiayu Jin, Liangyan Wang, Bing Tian, Yuejin Hua, Ye Zhao   +12 more
openaire   +2 more sources

Quantitative Global Proteome and Lysine Succinylome Analyses Reveal the Effects of Energy Metabolism in Renal Cell Carcinoma

PROTEOMICS, 2018
AbstractIn light of the increasing incidence of renal cell carcinoma (RCC), its molecular mechanisms have been comprehensively explored in numerous recent studies. However, few studies focus on the influence of multi‐factor interactions during the occurrence and development of RCC. This study aims to investigate the quantitative global proteome and the
Naiwen, Zhang, Ruxu, Gao, Jianyu, Yang, Yuyan, Zhu, Zhe, Zhang, Xiaolong, Xu, Jianfeng, Wang, Xiankui, Liu, Zeliang, Li, Zhenhua, Li, Daxin, Gong, Jun, Li, Jianbin, Bi, Chuize, Kong   +13 more
openaire   +2 more sources

Novel high-resolution ion mobility mass spectrometry for site-specific quantification of the sirtuin-5 regulated kidney succinylome

Abstract Protein post-translational modifications (PTMs) dynamically regulate essential biological and cellular processes. Lysine succinylation changes the amino acid charge, potentially affecting protein structures and functions, and dysregulation of protein succinylation may lead to metabolic disorders.
Birgit Schilling, Leonard Rorrer, Lauren Royer, Anne Silva-Barbosa, Katherine Pfister, Eric Goetzman, Sunder Sims-Lucas, Daniel DeBord, Joanna Bons   +8 more
openaire   +1 more source