Results 261 to 270 of about 1,032,066 (371)
Equivalent outcomes of human oocytes after vitrification or slow freezing with a modified rehydration protocol. [PDF]
Papis K+5 more
europepmc +1 more source
The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie+5 more
wiley +1 more source
RELATIVE HUMIDITY AND THE KILLING OF BACTERIA: THE SURVIVAL OF SERRATIA MARCESCENS DEHYDRATED BY CONCENTRATED GLYCEROL AND SUCROSE SOLUTIONS [PDF]
J. B. Bateman, F. E. White
openalex +1 more source
Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts
Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin+9 more
wiley +1 more source
Effects of organic compounds on the macroalgae culture of Aegagropila linnaei
Messyasz Beata+5 more
doaj +1 more source
Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu+11 more
wiley +1 more source
It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng+6 more
wiley +1 more source