Results 1 to 10 of about 10,379 (219)

Deciphering the Impact of Mutations on PfDHPS Active Site and Sulfadoxine Binding: Structural Insights from Molecular Dynamics Simulations [PDF]

Molecules
The antimalarial combination of sulfadoxine–pyrimethamine is used as a preventive treatment in pregnant women and children in Africa. Sulfadoxine inhibits the Plasmodium falciparum dihydropteroate synthase (PfDHPS), but resistance has emerged through ...
Emilie Guémas, Sandie Ménard, Nicolas Jeanne, Georges Landa, Antoine Berry, Marie Brut   +5 more
doaj   +4 more sources

Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum

PLoS Pathogens, 2010
The Thailand-Cambodia border is the epicenter for drug-resistant falciparum malaria. Previous studies have shown that chloroquine (CQ) and pyrimethamine resistance originated in this region and eventually spread to other Asian countries and Africa ...
Sumiti Vinayak, Naman K Shah, Pharath Lim   +2 more
exaly   +5 more sources

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention [PDF]

Nature Communications
Sulfadoxine-pyrimethamine (SP) is recommended for perennial malaria chemoprevention in young children in high burden areas across Africa. Mutations in the dihydropteroate synthase (dhps) gene (437 G/540E/581 G) associated with sulfadoxine resistance vary
Andria Mousa, Gina Cuomo-Dannenburg, Hayley A. Thompson, David J. Bell, Umberto D’Alessandro, Roly Gosling, Alain Nahum, Karen I. Barnes, Jaishree Raman, Lesley Workmann, Yong See Foo, Jennifer A. Flegg, Emma Filtenborg Hocke, Helle Hansson, Ana Chopo-Pizarro, Khalid B. Beshir, Michael Alifrangis, R. Matthew Chico, Colin J. Sutherland, Lucy C. Okell, Cally Roper   +20 more
doaj   +4 more sources

Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo [PDF]

Journal of Toxicology, 2022
Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product.
Rachida Moussa Tari, Aboudoulatif Diallo, Emmanuelle Kouame, Phénix Assogba, Essotolom Badjabaissi, Lawson-Evi Povi, Batomayena Bakoma, Yao Potchoo, Kokou Tona   +8 more
doaj   +2 more sources

Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. [PDF]

PLoS Medicine
BackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Abel Kakuru, Jimmy Kizza, Miriam Aguti, Harriet Adrama, John Ategeka, Peter Olwoch, Miriam Nakalembe, Joaniter I Nankabirwa, Bishop Opira, Nida Ozarslan, Anju Ranjit, Erin Dela Cruz, Tamara D Clark, Michelle E Roh, Stephanie L Gaw, Prasanna Jagannathan, Philip J Rosenthal, Moses R Kamya, Grant Dorsey   +18 more
doaj   +2 more sources

Dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy: a systematic review and individual participant data meta-analysisResearch in context [PDF]

EClinicalMedicine
Summary: Background: High-grade Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in east and southern Africa has prompted trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an ...
Michelle E. Roh, Julie R. Gutman, Maxwell Murphy, Jenny Hill, Mywayiwawo Madanitsa, Abel Kakuru, Hellen C. Barsosio, Simon Kariuki, John P.A. Lusingu, Frank Mosha, Richard Kajubi, Moses R. Kamya, Don Mathanga, Jobiba Chinkhumba, Miriam K. Laufer, Eulambius Mlugu, Appolinary A.R. Kamuhabwa, Eleni Aklillu, Omary Minzi, Roland Nnaemeka Okoro, Ado Danazumi Geidam, John David Ohieku, Meghna Desai, Prasanna Jagannathan, Grant Dorsey, Feiko O. ter Kuile   +25 more
doaj   +2 more sources

Audit of failure rate of sulfadoxine/pyrimetham combined with chloroquine to treat falciparum malaria at single fourteen-day follow-up

South African Family Practice, 2002
Objective: To assess the failure rate of the present first line treatment regime for uncomplicated falciparum malaria of sulfadoxine/pyrimethamine combined with chloroquine. Design: A before-after study. Setting: Ndumo Clinic, Ingwavuma District, South
C.H. Vaughan Williams, C. La Cock, G.F.J. Henry, A.J. Ross   +3 more
doaj   +3 more sources

Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso [PDF]

Antimicrobial Agents and Chemotherapy, 2015
Issaka Zongo, Paul Jm Milligan, Brian Greenwood   +2 more
exaly   +2 more sources

Efficacy of Corticosteroids and Intravenous Immunoglobulins in a Patient with Toxic Epidermal Necrolysis Secondary to Sulfadoxine: A Case Report and Literature Review

Reports, 2023
Toxic epidermal necrolysis (TEN) is a rare life-threatening mucocutaneous reaction characterized by epidermal detachment. Treatment success relies on early diagnosis, rapid withdrawal of the causative drug and supportive care.
Alba Escolà-Rodríguez, Ángel Marcos-Fendian, Carla Bastida, Javier Gil Lianes, Pedro Castro, José Manuel Mascaró, Dolors Soy Muner   +6 more
doaj   +1 more source

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 2008 to 2017

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort
Sabyasachi Das, Sabyasachi Das, Satyajit Tripathy, Ankita Das, Meenakshi Kumari Sharma, Ayan Nag, Amiya Kumar Hati, Somenath Roy   +7 more
doaj   +1 more source