Results 1 to 10 of about 20,006 (291)

Assessment of the Teratogenic Effect of Sulfadoxine-Pyrimethamine on the Chicken Embryo

Journal of Toxicology, 2022
Background. The sulfadoxine-pyrimethamine combination is a product used in the intermittent preventive treatment (IPT) of malaria in pregnant women in our country. To date, there is very little data on the teratogenic effect of this product. This study proposed to evaluate the teratogenic effect of sulfadoxine-pyrimethamine on chicken embryos. Methods.
Rachida Moussa Tari, Aboudoulatif Diallo, Emmanuelle Kouame, Phénix Assogba, Essotolom Badjabaissi, Lawson-Evi Povi, Batomayena Bakoma, Yao Potchoo, Kokou Tona   +8 more
doaj   +4 more sources

A roadmap for understanding sulfadoxine-pyrimethamine in malaria chemoprevention. [PDF]

Parasitology
Sulfadoxine-pyrimethamine (SP) is the standard of care for Plasmodium falciparum malaria chemoprevention among pregnant women, infants, and children. However, SP’s antimalarial effectiveness is potentially threatened by resistant parasites. Developing alternative chemoprevention products and other prevention products, such as vaccines and monoclonal ...
Masserey T, Braunack-Mayer L, Miller RS, Möhrle JJ, Penny MA.   +4 more
europepmc   +3 more sources

Artesunate-, sulfadoxine-, and pyrimethamine-induced cardiotoxicity

BLDE University Journal of Health Sciences, 2016
Here, we report oral artesunate, sulphadoxine and pyrimethamine (sp) induced cardio toxicity case in a female patient. Artesunate is a highly efficacious and relatively safe antimalarial drug. Common adverse reactions to artemisinin derivatives are mild i.e. nausea, vomiting, anorexia and dizziness which are seen in majority of the patients.
Shafiqa Aslam, Divya Goel, Rani Walia, Akshay Sadhotra   +3 more
openaire   +4 more sources

Spectrophotometric Estimation of Sulfadoxine in Pharmaceutical Preparations

Journal of Chemistry, 2010
Four simple, sensitive, accurate and rapid visible spectrophotometric methods (A, B, C and D) have been developed for the estimation of sulfadoxine in pharmaceutical preparations. They are based on the diazotization of sulfadoxine with sodium nitrite and hydrochloric acid followed by coupling with N‐(1‐naphthyl) ethylenediamine dihydrochloride (Method ...
Madhurjya Neog, Dipti Dabhi, Vipul Prajapati, Sangita Sharma, Hiren Patel   +4 more
openaire   +3 more sources

Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum

PLoS Pathogens, 2010
The Thailand-Cambodia border is the epicenter for drug-resistant falciparum malaria. Previous studies have shown that chloroquine (CQ) and pyrimethamine resistance originated in this region and eventually spread to other Asian countries and Africa. However, there is a dearth in understanding the origin and evolution of dhps alleles associated with ...
Steven R. Meshnick, Venkatachalam Udhayakumar, Naman K. Shah, Sinuon Muth, Pharath Lim, William O. Rogers, Chansuda Wongsrichanalai, Rithy Sem, Andrea M. McCollum, Frederick Ariey, Tauqeer Alam, Thierry Fandeur, Sumiti Vinayak, John W. Barnwell, Tonya Mixson-Hayden, Ananias A. Escalante   +15 more
openaire   +6 more sources

Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria [PDF]

Cochrane Database of Systematic Reviews, 2004
Artemisinin-based combination treatments are strongly advocated, but supplies are limited. Sulfadoxine combined with amodiaquine is an alternative non-artemisinin combination.To compare sulfadoxine-pyrimethamine plus amodiaquine (SP plus AQ) with sulfadoxine-pyrimethamine plus artesunate (SP plus AS) for treating uncomplicated Plasmodium falciparum ...
Bukirwa H, Critchley JA
openaire   +4 more sources

Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar). [PDF]

Thorax, 1989
A patient developed eosinophilic peripheral pulmonary infiltrates while receiving malaria prophylaxis with sulfadoxine-pyrimethamine (Fansidar). Withdrawal of Fansidar and treatment with corticosteroids led to rapid recovery. No exacerbation occurred after cessation of corticosteroids.
J. Holzschuh, Peter A. Berg, P. T. Daniel   +2 more
openaire   +3 more sources

Sulfadoxine-pyrimethamine for uncomplicated falciparum malaria: Sulfadoxine-pyrimethamine is not working in Malawi [PDF]

BMJ, 2004
EDITOR—The paper by Plowe et al entitled “Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria” might be better titled “Sustained lack of efficacy of sulfadoxine-pyrimethamine….”1 By the start of the study period five years ago, molecular genotyping showed that Plasmodium falciparum in Malawi had already ...
openaire   +2 more sources

Pharmacokinetic Properties of Sulfadoxine-Pyrimethamine in Pregnant Women [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were given a single dose of ...
Karunajeewa, H., Salman, S., Mueller, I., Baiwog, F., Gomorrai, P., Law, I., Page-Sharp, Madhu, Rogerson, S., Siba, P., Ilett, K., Davis, T.   +10 more
openaire   +4 more sources

Antimalarial efficacy of sulfadoxine–pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine–pyrimethamine in Bundi Bugyo, western Uganda [PDF]

Tropical Medicine & International Health, 2004
SummaryWe report below an in vivo antimalarial efficacy study conducted in 2002 in Bundi Bugyo, a district of western Uganda housing a large displaced population. We tested sulfadoxine–pyrimethamine (SP), amodiaquine (AQ) and the combination chloroquine plus SP (CQ + SP).
Francesco Checchi, Suna Balkan, Gerardo Priotto, Derryck Klarkowski, Eric Kwezi, Nathan Bakyaita, Elisa Ardizzoni, Cara S. Kosack, Jean-Paul Guthmann, Alan Brockman, Patrice Piola   +10 more
openaire   +3 more sources