Results 21 to 30 of about 20,006 (291)

Efficacy of Corticosteroids and Intravenous Immunoglobulins in a Patient with Toxic Epidermal Necrolysis Secondary to Sulfadoxine: A Case Report and Literature Review

Reports, 2023
Toxic epidermal necrolysis (TEN) is a rare life-threatening mucocutaneous reaction characterized by epidermal detachment. Treatment success relies on early diagnosis, rapid withdrawal of the causative drug and supportive care.
Alba Escolà-Rodríguez, Ángel Marcos-Fendian, Carla Bastida, Javier Gil Lianes, Pedro Castro, José Manuel Mascaró, Dolors Soy Muner   +6 more
doaj   +1 more source

Molecular Markers for Sulfadoxine/Pyrimethamine and Chloroquine Resistance in Plasmodium falciparum in Thailand

Korean Journal of Parasitology, 2022
Drug resistance is an important problem hindering malaria elimination in tropical areas. Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes confer resistance to antifolate drug ...
Jiraporn Kuesap, Nutnicha Suphakhonchuwong, Lertluk Kalawong, Natthaya Khumchum   +3 more
semanticscholar   +1 more source

Chloroquine and Sulfadoxine–Pyrimethamine Resistance in Sub-Saharan Africa—A Review

Frontiers in Genetics, 2021
Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease.
A. Roux, Leah Maharaj, O. Oyegoke, Oluwasegun P. Akoniyon, M. Adeleke, R. Maharaj, Moses Okpeku   +6 more
semanticscholar   +1 more source

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 2008 to 2017

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionAfter being used vigorously for the previous two decades to treat P. falciparum, chloroquine and sulfadoxine-pyrimethamine were replaced in 2009 with an artemisinin-based combination therapy (artesunate-sulfadoxine-pyrimethamine) in an effort
Sabyasachi Das, Sabyasachi Das, Satyajit Tripathy, Ankita Das, Meenakshi Kumari Sharma, Ayan Nag, Amiya Kumar Hati, Somenath Roy   +7 more
doaj   +1 more source

Antimalarial drug sulfadoxine induces gametocytogenesis in Plasmodium berghei. [PDF]

Malar J
Background The spread of antimalarial drug resistance parasites is a major obstacle in eliminating malaria in endemic areas. This increases the urgency for developing novel antimalarial drugs with improved profiles to eliminate both sensitive and ...
Azmi WA, Rizki AFM, Shidiq A, Djuardi Y, Artika IM, Siregar JE.   +5 more
europepmc   +2 more sources

Impact of dhps mutations on sulfadoxine-pyrimethamine protective efficacy and implications for malaria chemoprevention. [PDF]

Nat Commun
Sulfadoxine-pyrimethamine (SP) is recommended for perennial malaria chemoprevention in young children in high burden areas across Africa. Mutations in the dihydropteroate synthase (dhps) gene (437 G/540E/581 G) associated with sulfadoxine resistance vary
Mousa A, Cuomo-Dannenburg G, Thompson HA, Bell DJ, D'Alessandro U, Gosling R, Nahum A, Barnes KI, Raman J, Workmann L, Foo YS, Flegg JA, Hocke EF, Hansson H, Chopo-Pizarro A, Beshir KB, Alifrangis M, Chico RM, Sutherland CJ, Okell LC, Roper C.   +20 more
europepmc   +2 more sources

Low prevalence of highly sulfadoxine‐resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin

Malaria Journal, 2021
Background In 2004, in response to high levels of treatment failure associated with sulfadoxine-pyrimethamine (SP) resistance, Benin changed its first-line malaria treatment from SP to artemisinin-based combination therapy for treatment of uncomplicated ...
S. S. Svigel, A. Adéothy, Augustin Kpemasse, Ernest Houngbo, A. Sianou, Ramani Saliou, M. Patton, Fortuné Dagnon, Eric S. Halsey, Alexis Tchévoédé, V. Udhayakumar, N. Lucchi   +11 more
semanticscholar   +1 more source

Chloroquine and Sulfadoxine Derivatives Inhibit ZIKV Replication in Cervical Cells

Viruses, 2020
Despite the severe morbidity caused by Zika fever, its specific treatment is still a challenge for public health. Several research groups have investigated the drug repurposing of chloroquine.
Audrien Alves Andrade de Souza, Lauana Ribas Torres, Lyana Rodrigues Pinto Lima Capobianco, Vanessa Salete de Paula, Cynthia Machado Cascabulho, Kelly Salomão, Maria da Gloria Bonecini-Almeida, Maria de Lourdes Garcia Ferreira, Nubia Boechat, Luiz Carlos da Silva Pinheiro, Elen Mello de Souza   +10 more
doaj   +1 more source

Decreasing burden of malaria in pregnancy in Malawian women and its relationship to use of intermittent preventive therapy or bed nets. [PDF]

PLoS ONE, 2010
The World Health Organization recommends insecticidal bednets and intermittent preventive treatment to reduce malaria in pregnancy. Longitudinal data of malaria prevalence and pregnancy outcomes are valuable in gauging the impact of these antimalarial ...
Gaoqian Feng, Julie A Simpson, Ebbie Chaluluka, Malcolm E Molyneux, Stephen J Rogerson   +4 more
doaj   +1 more source

Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in Africa: a systematic analysis of national trends

BMJ Global Health, 2020
Introduction The rising burden of drug resistance is a major challenge to the global fight against malaria. We estimated national Plasmodium falciparum resistance to sulfadoxine-pyrimethamine (SP) across Africa, from 2000 to 2020.
F. Amimo, B. Lambert, A. Magit, J. Sacarlal, M. Hashizume, K. Shibuya   +5 more
semanticscholar   +1 more source