Results 41 to 50 of about 10,379 (219)

Impact of antimalarial resistance and COVID-19 pandemic on malaria care among pregnant women in Northern Uganda (ERASE): protocol of a prospective observational study

BMC Infectious Diseases, 2022
Background Uganda accounts for 5% of all malaria cases and deaths reported globally and, in endemic countries, pregnancy is a risk factor for both acquisition of P. falciparum infection and development of severe malaria.
Francesco Vladimiro Segala, Francesco Di Gennaro, Jerry Ictho, Mariangela L’Episcopia, Emmanuel Onapa, Claudia Marotta, Elda De Vita, James Amone, Valentina Iacobelli, Joseph Ogwang, Giovanni Dall’Oglio, Benedict Ngole, Rita Murri, Lameck Olal, Massimo Fantoni, Samuel Okori, Giovanni Putoto, Carlo Severini, Peter Lochoro, Annalisa Saracino   +19 more
doaj   +1 more source

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster‐Randomised Trial

Maternal &Child Nutrition, Volume 21, Issue 4, October 2025.
Globally nearly 40% of children under 5 years old are anaemic, which affects their ability to grow and develop. A cluster randomised trial was conducted in 60 communities in Southern Mali to evaluate the added impact of home fortification with micronutrient powders, delivered alongside seasonal malaria chemoprevention, on anaemia, malaria infection ...
Niélé H. Diarra, Yahia Dicko, Natalie Roschnik, Modibo Bamadio, Michael Boivin, Yvonne Griffiths, Rebecca Jones, Sham Lal, Helen Moestue, Hamidou Niangaly, Lauren Pisani, Renion Saye, Kalifa Sidibe, Karla Smuts, Nia‐An Philippe Thera, Josselin Thuilliez, Hans Verhoef, Moussa Sacko, Siân E. Clarke   +18 more
wiley   +1 more source

The Efficacy of Zinc Supplementation Alone or in Combination for Improving Pregnancy and Infant Outcomes: A Systematic Review and Meta‐Analysis

Journal of Evidence-Based Medicine, Volume 18, Issue 3, September 2025.
ABSTRACT Objective To evaluate zinc supplementation's efficacy in pregnancy, addressing gaps in previous reviews regarding high‐risk subgroups and combination therapies. Methods Systematic review of six databases through March 27, 2025 for randomized controlled trials (RCTs) on prenatal zinc supplementation. Risk of bias was assessed using the Cochrane
Sha Diao, Yuan Feng, Xue Peng, Dan Liu, Liang Huang, Linan Zeng, Lingli Zhang   +6 more
wiley   +1 more source

Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy

Emerging Infectious Diseases, 2010
For monitoring efficacy of sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy, data obtained from studies of children seemed inadequate. High prevalence of triple and quadruple mutants in the dihydropteroate synthase
Philippe Deloron, Gwladys Bertin, Valérie Briand, Achille Massougbodji, Michel Cot   +4 more
doaj   +1 more source

Concentration–Response Analysis of the Combination of Pyronaridine and Piperaquine on Corrected QT Interval From a Randomized, Double‐Blind, Placebo‐Controlled Study in Healthy Adults of African Sub‐Saharan Origin

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT A novel oral combination of the long‐acting antimalarials pyronaridine (PYR) and piperaquine (PQP) has potential for malaria chemoprevention. This single‐center randomized, double‐blind, placebo‐controlled study assessed the effects of PYR and PQP alone and when co‐administered on Fridericia‐corrected QT interval (QTcF).
Mathieu Felices, Isabelle Borghini‐Fuhrer, Nada Abla, Stephan Chalon   +3 more
wiley   +1 more source

A Novel Inhibitor against the Bromodomain Protein 1 of the Malaria Pathogen Plasmodium Falciparum

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
This article presents the development of a first‐in‐class inhibitor targeting the bromodomain protein PfBDP1 in Plasmodium falciparum, the deadliest variant of the malaria‐causing Plasmodium parasites. Through structure‐based drug design, the inhibitor interactions were characterized via X‐ray crystallography and isothermal titration calorimetry ...
Marius Amann, Robin Warstat, Kay Kristin Rechten, Philip Theuer, Magdalena Schustereder, Sophie Clavey, Bernhard Breit, Oliver Einsle, Martin Hügle, Michaela Petter, Stefan Günther   +10 more
wiley   +1 more source

Dairy goat sulfadoxine depletion trial in milk and diagnostic accuracy of the Charm Rapid One Step Assay (ROSA) SULF test

JDS Communications
In Canada, currently no antibiotics are approved for use in lactating dairy goats. Trimethoprim sulfadoxine is indicated for the treatment of bacterial pneumonia, enteric and septicemic colibacillosis and salmonellosis, infectious pododermatitis, and ...
Miranda Hawley, Joe Smith, Kaitlyn Lawson, Jocelyn Jansen, Rex Crawford, Afolakemi Adeniji, Cathy Bauman   +6 more
doaj   +1 more source

A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women. [PDF]

PLoS ONE, 2007
New anti-malarial regimens are urgently needed in sub-Saharan Africa because of the increase in drug resistance. We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for treatment of malaria ...
Linda Kalilani, Innocent Mofolo, Marjorie Chaponda, Stephen J Rogerson, Alisa P Alker, Jesse J Kwiek, Steven R Meshnick   +6 more
doaj   +1 more source

Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism

Advanced Science, Volume 12, Issue 19, May 22, 2025.
By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini, Sabrina Mechaussier, Carolina Campos Pina, Monica Morais, Olivier Postal, Philippe Jean, Typhaine Dupont, Amrit Singh‐Estivalet, Shéhanie Udugampolage, Cyril Scandola, Elisabeth Verpy, Baptiste Libé‐Philippot, Talya C. Inbar, Joanna Schwenkgrub, Carla Maria Barbosa Spinola, Raphaël Etournay, Aziz El‐Amraoui, Brice Bathellier, Adeline Mallet, Sedigheh Delmaghani, Fabrice Giraudet, Christine Petit, Boris Gourévitch, Paul Avan, Nicolas Michalski   +24 more
wiley   +1 more source

Miniaturized green liquid‐phase sample pre‐concentration methods for pharmaceutical drugs assessment in wastewater

Water and Environment Journal, Volume 39, Issue 2, Page 143-167, May 2025.
Abstract Microextraction methods such as hollow fibre‐liquid phase microextraction (HF‐LPME), dispersive liquid–liquid microextraction (DLLME), single‐drop microextraction (SDME) and ultrasound‐assisted emulsification microextraction (USAEME) have become prominent for analysing pharmaceuticals in wastewater. HF‐LPME, particularly the three‐phase system,
Bavuyile Magqira, Precious Mahlambi
wiley   +1 more source