Results 1 to 10 of about 1,720 (167)

Silver Catalyzed Site-Selective C(sp³)−H Bond Amination of Secondary over Primary C(sp³)−H Bonds [PDF]

Molecules, 2022
Sulfamates are widespread in numerous pharmacologically active molecules. In this paper, Silver/Bathophenanthroline catalyzed the intramolecular selective amination of primary C(sp3)−H bonds and secondary C(sp3)−H bonds of sulfamate esters, to produce ...
Luzhen Jiao, Dawei Teng, Zixuan Wang, Guorui Cao   +3 more
doaj   +2 more sources

Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A β-class carbonic anhydrase (CA, EC 4.2.1.1) present in the genome of the Monogenean platyhelminth Gyrodactylus salaris, a fish parasite, GsaCAβ, has been investigated for its inhibitory effects with a panel of sulphonamides and sulfamates, some of ...
Ashok Aspatwar, Alessandro Bonardi, Heidi Aisala, Ksenia Zueva, Craig R Primmer, Jaakko Lumme, Seppo Parkkila, Claudiu T. Supuran   +7 more
doaj   +2 more sources

Sulfamates and Their Therapeutic Potential [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
J. Winum, SCOZZAFAVA, ANDREA, J. Montero, SUPURAN, CLAUDIU TRANDAFIR   +3 more
openaire   +4 more sources

Arylsulfonamido-alkyl-sulfamates act as inhibitors of bovine carbonic anhydrase II

European Journal of Medicinal Chemistry Reports
A small library of arylsulfonamido-alkyl sulfamates was prepared by a two-step synthesis from readily available starting materials. The compounds were tested for their ability to inhibit bovine carbonic anhydrase II.
Toni C. Denner, Niels V. Heise, René Csuk   +2 more
doaj   +2 more sources

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis.
Claudiu T. Supuran
doaj   +2 more sources

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. [PDF]

PLoS Pathogens
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates.
Stanley C Xie, Chia-Wei Tai, Craig J Morton, Liting Ma, Shih-Chung Huang, Sergio Wittlin, Yawei Du, Yongbo Hu, Con Dogovski, Mina Salimimarand, Robert Griffin, Dylan England, Elisa de la Cruz, Ioanna Deni, Tomas Yeo, Anna Y Burkhard, Josefine Striepen, Kyra A Schindler, Benigno Crespo, Francisco J Gamo, Yogesh Khandokar, Craig A Hutton, Tayla Rabie, Lyn-Marié Birkholtz, Mufuliat T Famodimu, Michael J Delves, Judith Bolsher, Karin M J Koolen, Rianne van der Laak, Anna C C Aguiar, Dhelio B Pereira, Rafael V C Guido, Darren J Creek, David A Fidock, Lawrence R Dick, Stephen L Brand, Alexandra E Gould, Steven Langston, Michael D W Griffin, Leann Tilley   +39 more
doaj   +2 more sources

Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target. [PDF]

PLoS Pathogens
Malaria poses an enormous threat to human health. With ever-increasing resistance to currently deployed antimalarials, new targets and starting point compounds with novel mechanisms of action need to be identified.
Nutpakal Ketprasit, Chia-Wei Tai, Vivek Kumar Sharma, Yogavel Manickam, Yogesh Khandokar, Xi Ye, Con Dogovski, David H Hilko, Craig J Morton, Anne-Sophie C Braun, Michael G Leeming, Bagale Siddharam, Gerald J Shami, Pushpangadan Indira Pradeepkumar, Santosh Panjikar, Sally-Ann Poulsen, Michael D W Griffin, Amit Sharma, Leann Tilley, Stanley C Xie   +19 more
doaj   +2 more sources

Rearrangement of Arylsulfamates and Sulfates to Para-Sulfonyl Anilines and Phenols [PDF]

Molecules
The C(sp2)-aryl sulfonate functional group is found in bioactive molecules, but their synthesis can involve extreme temperatures (>190 °C or flash vacuum pyrolysis) and strongly acidic reaction conditions.
Yifei Zhou, Alan M. Jones
doaj   +2 more sources

Computational insights into novel inhibitors: virtual screening of small molecules against human carbonic anhydrase II [PDF]

Frontiers in Chemistry
Carbonic anhydrases, zinc-based metalloproteins, facilitate the reversible conversion of CO2 into carbonic acid when transported through blood vessels and subsequently regulate the physiological pH.
Sermarajan Arunachalam, Balamurali M. M., Ramachandran Gnanasekaran   +2 more
doaj   +2 more sources

An attempt to prepare sulfonyl analogues of fotemustine: unexpected rearrangement to sulfamate during nitrosation step. [PDF]

RSC Adv, 2023
Aouf Z, Boughaba S, Sayad R, Lebreton J, Mathe-Allainmat M, Aouf NE.   +5 more
europepmc   +3 more sources