Results 61 to 70 of about 4,042 (165)

Isosteviol – A new scaffold for the synthesis of carbonic anhydrase II inhibitors

Results in Chemistry
The diterpene isosteviol can easily be synthesized via hydrolysis from stevioside, a renewable resource adding particular utility to its potential for drug synthesis. Of late, there has been an increase in scientific studies focusing on inhibitors of the
Toni C. Denner, Niels V. Heise, René Csuk   +2 more
doaj   +1 more source

Photochemistry of N‐Substituted, N′‐Tosyl Diphenyl Sulfondiimines

Journal of Physical Organic Chemistry, Volume 39, Issue 8, August 2026.
The irradiation of N‐substituted, N′‐tosyl diphenyl sulfondiimines with UV light induces the sequential photorelease of two different nitrenes. ABSTRACT Sulfondiimines are an emerging sulfur(VI) functional group with increasing use in synthesis and medicinal chemistry, yet their photochemical behavior has remained largely unexplored.
Bashar Aziz, Paul Danyi, John P. Carney, Ryan D. McCulla   +3 more
wiley   +1 more source

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.

Bioorganic chemistry (Print), 2019
Herein we report for the first time an efficient synthetic procedure for the preparation of N-aryl-N'-ureido-O-sulfamates (AUSs) as a new class of Carbonic Anhydrase Inhibitors (CAIs).
M. Bozdağ, G. Poli, A. Angeli, E. Lucarini, T. Tuccinardi, L. di Cesare Mannelli, S. Selleri, C. Ghelardini, J. Winum, F. Carta, C. Supuran   +10 more
semanticscholar   +1 more source

Purification and Properties of Polyvinyl Nitrate and Its Compatibility With Solid Oxidizers

Propellants, Explosives, Pyrotechnics, Volume 51, Issue 8, Page 1224-1234, August 2026.
ABSTRACT Polyvinyl nitrate (PVN) is a nitrate‐ester energetic binder that can be produced directly from polyvinyl alcohol—a cheap commodity feedstock—thereby offering potential cost and supply‐chain advantages over binders based on nitrocellulose and other specialty polymers.
Stephen Spice, Monica C. Chandwani, Carole A. Morrison, Colin R. Pulham   +3 more
wiley   +1 more source

A Sulfonative rearrangement of N-aryl sulfamates to para-sulfonyl anilines [PDF]

, 2022
The C(sp2)-aryl sulfonate functional group is widely found in bioactive scaffolds but can often only be accessed under forcing temperatures (>190 °C) and corrosive reaction conditions.
Jones, Alan M; id_orcid, Zhou, Yifei, Alan, Jones, Yifei, Zhou   +3 more
core   +2 more sources

1‐Aryl‐6,7‐Dimethoxy‐3,4‐Dihydroisoquinoline‐2(1H)‐Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Experimental and theoretical studies have disclosed the more relevant structural requirements for effective inhibition and an impressing selectivity toward tumor‐expressed hCA XII isoform over hCA II. Human carbonic anhydrase XII (hCA XII) represents an important pharmacological target for different types of cancer.
Federico Ricci, Anna Di Fiore, Andrea Angeli, Laura De Luca, Francesca Mancuso, Davide Esposito, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto   +8 more
wiley   +1 more source

Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.

European journal of medicinal chemistry, 2019
In the present article, we reviewed the sulfamate-containing compounds reported as bioactive molecules. The possible molecular targets of sulfamate derivatives include steroid sulfatase enzyme, carbonic anhydrases, acyl transferase, and others. Sulfamate
Seyed-Omar Zaraei, Abduelmula R Abduelkarem, Hanan S. Anbar, Sara Kobeissi, Miami Mohammad, Aya Ossama, M. El-Gamal   +6 more
semanticscholar   +1 more source

Coupling Anodic Activity and Stability at Ni‐Based Non‐Oxide Catalysts via Coordinating Alcohol Oxidation and Oxygen Evolution

Advanced Functional Materials, Volume 36, Issue 57, 16 July 2026.
A cooperative and competitive interrelationship between alcohol oxidation (AOR) and water oxidation (OER) was observed on a typical anode catalyst of Ni2P. In situ Raman spectroscopy and electrochemical analyses revealed a specific complementary mechanism between them, in which OER and AOR critically contribute to the activity and stability of anodic ...
Yong Yan, Xinyu Liu, Yuguo Zhao, Hanwen Jian, Huan Zhou, Riyi Zhang, Dong Wang, Peter Schaaf, Lihua Wang, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy.

Bioorganic chemistry (Print), 2018
Herein we report the synthesis of a new series of aromatic sulfamates designed considering the sulfonamide COX-2 selective inhibitors celecoxib and valdecoxib as lead compounds.
A. Nocentini, D. Moi, G. Balboni, S. Salvadori, V. Onnis, C. Supuran   +5 more
semanticscholar   +1 more source

Palladium- and Nickel-Catalyzed Aminations of Aryl Imidazolylsulfonates and Sulfamates

, 2016
A nickel complex derived from dppf, along with NaOt-Bu as the base, allowed for challenging aminations of aryl sulfamates. An improved functional group tolerance is observed in novel palladium-catalyzed aminations of imidazolylsulfonates with rac-BINAP ...
René Sandmann (2202790), Weifeng Song (2216635), Lutz Ackermann (1392253)   +2 more
core   +1 more source