Results 71 to 80 of about 4,042 (165)

Engineering Trace‐Amount Electrolyte Additives for Aqueous Zinc Batteries

Advanced Energy Materials, Volume 16, Issue 22, 10 June 2026.
Large‐amount additives primarily modify the bulk electrolyte by coordinating with Zn2+ or reshaping the hydrogen‐bond network, thereby altering the overall solution chemistry. In contrast, trace‐amount additives mainly operate at the electrode–electrolyte interface, regulating Zn deposition through electric double‐layer modulation, interfacial ...
Zhaoxin Li, Jinhua Guo, Longjun Chang, Zhenyu Jiang, Shuchang Liu, Chao Wang, Qi Liu, Baohua Li, Zhiqiang Niu, Qing Li   +9 more
wiley   +1 more source

Computational insights into novel inhibitors: virtual screening of small molecules against human carbonic anhydrase II

Frontiers in Chemistry
Carbonic anhydrases, zinc-based metalloproteins, facilitate the reversible conversion of CO2 into carbonic acid when transported through blood vessels and subsequently regulate the physiological pH.
Sermarajan Arunachalam, Balamurali M. M., Ramachandran Gnanasekaran   +2 more
doaj   +1 more source

Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors.

European journal of medicinal chemistry, 2019
Two new piperazinyl-ureido single ring aryl sulfamate-based inhibitor series were designed against the emerging oncology drug target steroid sulfatase (STS), for which there are existing potent steroidal and non-steroidal agents in clinical trials.
D. Moi, P. Foster, Lucy Rimmer, A. Jaffri, A. Deplano, G. Balboni, V. Onnis, B. Potter   +7 more
semanticscholar   +1 more source

Synthesis of a C‐2 Functionalized l‐Iduronic Acid Derivative as a Candidate Pharmacological Chaperone for MPS II (Hunter Syndrome)

Chemistry – An Asian Journal, Volume 21, Issue 11, 15 June 2026.
A C‐2 functionalized l‐iduronic acid derivative was designed and synthesized as a candidate pharmacological chaperone for iduronate‐2‐sulfatase (IDS), the enzyme involved in the lysosomal storage disease MPS II (Hunter syndrome). The synthesis overcomes significant synthetic challenges associated with manipulations of L‐ido scaffolds.
Vaibhavi Nagendra, Shifaza Mohamed, Nicholas W. See, Norbert Wimmer, Daniel Neumann, Paul J. Trim, Marten Snel, Aidan J. Brock, Jack K. Clegg, Neha S. Gandhi, Kim M. Hemsley, Adeline A. Lau, Vito Ferro   +12 more
wiley   +1 more source

Exudative Retinal Detachments: A Rare Adverse Effect of Topiramate

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Topiramate‐induced multifocal exudative retinal detachment is a rare but potentially vision‐threatening adverse effect. We report a 59‐year‐old woman with idiopathic intracranial hypertension who developed painless bilateral blurry vision and color desaturation 8 days after initiation of topiramate 25 mg twice daily.
Sarah Aljefri, Meshal Alzakari, Bailasan Milibari, Doaa Milibari   +3 more
wiley   +1 more source

Selective Rh(II)‐Catalyzed Intermolecular Oxyamidation and Acid‐Promoted Nucleophilic Cyclization Cascade of Enamides

ChemistryEurope, Volume 4, Issue 6, June 2026.
A structurally diverse series of 1‐amino‐izidine scaffolds was accessed through a cascade process combining rhodium‐catalyzed nitrene‐transfer oxyamidation with subsequent nucleophilic cyclization under acidic conditions, proceeding via an in situ generated iminium intermediate.
Grégory Jestin, Romain Rey‐Rodriguez, Romane Manguin, Pascal Retailleau, Philippe Dauban, Isabelle Gillaizeau   +5 more
wiley   +1 more source

Combination of Betulinic Acid Fragments and Carbonic Anhydrase Inhibitors—A New Drug Targeting Approach

Pharmaceutics
Human carbonic anhydrase IX (hCA IX) is a zinc(II)-dependent metalloenzyme that plays a critical role in the conversion of carbon dioxide and water to protons and bicarbonate.
Matthias Bache, Niels V. Heise, Andreas Thiel, Anne Funtan, Franziska Seifert, Marina Petrenko, Antje Güttler, Sarah Brandt, Thomas Mueller, Dirk Vordermark, Iris Thondorf, René Csuk, Reinhard Paschke   +12 more
doaj   +1 more source

DFT Investigation of Suzuki–Miyaura Reactions with Aryl Sulfamates Using a Dialkylbiarylphosphine-Ligated Palladium Catalyst

Organometallics, 2017
Aryl sulfamates are valuable electrophiles for cross-coupling reactions because they can easily be synthesized from phenols and can act as directing groups for C–H bond functionalization prior to cross-coupling.
Patrick R. Melvin, A. Nova, David Balcells, N. Hazari, M. Tilset   +4 more
semanticscholar   +1 more source

Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Objectives The heart–brain nexus is increasingly recognized as important for human health. Nonetheless, integration of this perspective in research and treatment remains limited in psychiatry, particularly in bipolar disorder (BD). Multisystem vascular imaging may help elucidate mechanisms linking heart and brain health in BD.
Megan Mio, Pao‐Huan Chen, Kody G. Kennedy, Hilary P. Blumberg, David J. Bond, Eric L. Goldwaser, Fabiano A. Gomes, Jody L. Greaney, Tomas Hajek, Susan L. McElroy, Roger S. McIntyre, Abigail Ortiz, Miguel L. Prieto, Elysha Ringin, Louisa G. Sylvia, Shang‐Ying Tsai, Jess G. Fiedorowicz, Benjamin I. Goldstein   +17 more
wiley   +1 more source

Fine-Tuning Strain and Electronic Activation of Strain-Promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs

Journal of the American Chemical Society, 2017
The ability to achieve predictable control over the polarization of strained cycloalkynes can influence their behavior in subsequent reactions, providing opportunities to increase both rate and chemoselectivity.
Eileen G. Burke, Brian Gold, Trish T. Hoang, R. T. Raines, J. Schomaker   +4 more
semanticscholar   +1 more source