Results 21 to 30 of about 31,137 (305)

Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration. [PDF]

PLoS ONE, 2016
Enzyme replacement therapy with intravenous idursulfase (recombinant iduronate-2-sulfatase) is approved for the treatment of Hunter syndrome. Intravenous administration does not, however, treat the neurological manifestations, due to its low central ...
Jou-Ku Chung, Eilish Brown, Bob Crooker, Kathleen J Palmieri, Thomas G McCauley   +4 more
doaj   +1 more source

Increasing productivity of arylsulfatase B-producing cell line by coexpression of formylglycine-generating enzyme

Биопрепараты: Профилактика, диагностика, лечение, 2022
Mucopolysaccharidosis type VI (Maroteaux–Lamy syndrome) is an orphan genetic disease caused by deficiency of the lysosomal enzyme arylsulfatase B (ASB).
S. S. Timonova, K. A. Smolova, D. T. Zaripova, M. S. Pantyushenko, M. A. Koroleva, R. L. Anisimov, R. A. Khamitov, A. A. Piskunov, V. N. Bade   +8 more
doaj   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Novel 3-Substituted 8-Methoxycoumarin Derivatives as Anti-Breast Cancer Drugs

Crystals, 2023
Scientists have been interested in hybrid coumarin derivatives due to their wide clinical anticancer use. Herein, ethyl 8-methoxycoumarin-3-carboxylate (Compound 1) served as the starting material for the synthesis of a series of novel hybrid coumarin ...
Tarfah Al-Warhi, Ola A. Abu Ali, Leena S. Alqahtani, Eman Abo-Elabass, Mohammed El Behery, Atef E. Abd El-Baky, Mohamed Samir A. Zaki, Eman Fayad, Eman M. Radwan   +8 more
doaj   +1 more source

The Development of a Smart Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer Contrast Agent for the Imaging of Sulfatase Activity

Pharmaceuticals, 2023
The molecular imaging of biomarkers plays an increasing role in medical diagnostics. In particular, the imaging of enzyme activity is a promising approach, as it enables the use of its inherent catalytic activity for the amplification of an imaging ...
Ilse M. Welleman, Friederike Reeβing, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Ben L. Feringa, Wiktor Szymanski   +5 more
doaj   +1 more source

Interactions of CFTR and Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) in Prostate Carcinoma. [PDF]

Int J Mol Sci
Bhattacharyya S, Tobacman JK.
europepmc   +3 more sources

A novel thermostable prokaryotic fucoidan active sulfatase PsFucS1 with an unusual quaternary hexameric structure

Scientific Reports, 2021
Fucoidans are sulfated, fucose-rich marine polysaccharides primarily found in cell walls of brown seaweeds (macroalgae). Fucoidans are known to possess beneficial bioactivities depending on their structure and sulfation degree.
M. Mikkelsen, H. T. Cao, T. Roret, Nanna Rhein-Knudsen, J. Holck, Van Thi Thanh Tran, Thuan Thi Nguyen, V. H. Tran, M. Lezyk, Jan Muschiol, T. D. Pham, M. Czjzek, A. Meyer   +12 more
semanticscholar   +1 more source

Steroid Sulfatase Deficiency [PDF]

Pediatric Research, 1977
Placental steroid sulfatase deficiency is a genetic disorder only recently reported in the medical literature. Most documented cases of placental sulfatase deficiency have been marked by delay in onset of labor, lack of cervical dilatation, and relative refractoriness of oxytocic agents and amniotomy. We have studied the placenta, cultured fibroblasts,
L J, Shapiro, L, Cousins, A L, Fluharty, R L, Stevens, H, Kihara   +4 more
openaire   +2 more sources

Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase

ACS Chemical Biology, 2017
Omkar P. Dhamale, Roger Lawrence, Elena Marie Wiegmann, Bhahwal Ali Shah, Kanar Al-Mafraji, William C. Lamanna, Torben Lübke, Thomas Dierks, Geert‐Jan Boons, Jeffrey D. Esko   +9 more
openalex   +3 more sources

Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs. [PDF]

Proceedings of the National Academy of Sciences, 1992
Multiple sulfatase deficiency (MSD) is an inherited lysosomal storage disease characterized by the deficiency of at least seven sulfatases. The basic defect in MSD is thought to be in a post-translational modification common to all sulfatases. In accordance with this concept, RNAs of normal size and amount were detected in MSD fibroblasts for three ...
Rommerskirch, Winfried, Figura, Kurt von
openaire   +3 more sources