Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
Enzyme replacement therapies: What is the best option? [PDF]
, 2018 Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the ...
Barar, Jaleh +4 more
core +2 more sources
The Importance of Steroid Uptake and Intracrine Action in Endometrial and Ovarian Cancers
Frontiers in Pharmacology, 2017 Endometrial and ovarian cancers predominately affect women after menopause, and are more frequently observed in developed countries. These are considered to be hormone-dependent cancers, as steroid hormones, and estrogens in particular, have roles in ...
Tea Lanišnik Rižner +2 more
doaj +1 more source
ACS Sensors, 2019 In this study, on the basis of the biomineralization capability of urease, a facile, one-step, and green synthetic method has been proposed for the fabrication of gold nanoclusters (AuNCs).
Haohua Deng +8 more
semanticscholar +1 more source
The Multiple Sulfatase Deficiency Gene Encodes an Essential and Limiting Factor for the Activity of Sulfatases [PDF]
Cell, 2003 In multiple sulfatase deficiency (MSD), a human inherited disorder, the activities of all sulfatases are impaired due to a defect in posttranslational modification. Here we report the identification, by functional complementation using microcell-mediated chromosome transfer, of a gene that is mutated in MSD and is able to rescue the enzymatic ...
COSMA MP +6 more
openaire +6 more sources
Longitudinal qPCR study of the dynamics of L. crispatus, L. iners, A. vaginae, (sialidase positive) G. vaginalis, and P. bivia in the vagina [PDF]
, 2012 Background: To obtain more detailed understanding of the causes of disturbance of the vaginal microflora (VMF), a longitudinal study was carried out for 17 women during two menstrual cycles.
Cools, Piet +9 more
core +7 more sources
Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling [PDF]
, 2016 The relative roles of SULF1 and SULF2 enzymes in tumour growth are controversial, but short SULF1/SULF2 splice variants predominate in human mammary tumours despite their non-detectable levels in normal mammary tissue. Compared with the normal, the level
Dhoot, G K +3 more
core +1 more source
Post-synthetic regulation of HS structure: the yin and yang of the Sulfs in Cancer
Frontiers in Oncology, 2014 Heparan sulfate (HS) is a complex polysaccharide that takes part in most major cellular processes, through its ability to bind and modulate a very large array of proteins.
Romain R Vives +2 more
doaj +1 more source
Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. [PDF]
PLoS ONE, 2013 The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate ...
Kimberly M Sogi +5 more
doaj +1 more source
Computational analysis of bacterial sulfatases and their modifying enzymes [PDF]
, 1998 The sequence analysis of enzymes that might modify bacterial sulfatases should be useful in the task of identifying the human sulfatase-modifying homologs — enzymes that are defective in the rare inherited disease multi-sulfatase ...
Kolter, Roberto, Schirmer, Andreas
core +1 more source