Results 61 to 70 of about 31,137 (305)

Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship [PDF]

Human Molecular Genetics, 2005
Sulfatases catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates. Several human inherited diseases are caused by the deficiency of individual sulfatases, while in patients with multiple sulfatase deficiency mutations in the Sulfatase Modifying Factor 1 (SUMF1) gene cause a defect in the post-translational modification of a ...
SARDIELLO M., ANNUNZIATA I., ROMA G., BALLABIO, ANDREA   +3 more
openaire   +3 more sources

SUMF1 enhances sulfatase activitiesin vivoin five sulfatase deficiencies [PDF]

Biochemical Journal, 2007
Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. The catalytic activity of sulfatases resides in a unique formylglycine residue in their active site generated by the post-translational ...
FRALDI, ALESSANDRO, A. Biffi, A. Lombardi, I. Visigalli, S. Pepe, SETTEMBRE, CARMINE, E. Nusco, AURICCHIO, ALBERTO, L. Naldini, BALLABIO, ANDREA, M. P. C.o.s.m.a.   +10 more
openaire   +4 more sources

Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle [PDF]

, 2014
peer-reviewedBackground Negative energy balance (NEB), an altered metabolic state, occurs in early postpartum dairy cattle when energy demands to support lactation exceed energy intake.
Fatima, Attia, Morris, Dermot G., O'Boyle, Padraig, Seoighe, Cathal, Waters, Sinead M.   +4 more
core   +1 more source

A Novel Sulfatase for Acesulfame Degradation in Wastewater Treatment Plants as Evidenced from Shinella Strains

bioRxiv
The artificial sweetener acesulfame is a persistent pollutant in wastewater worldwide. So far, only a few bacterial isolates were recently found to degrade acesulfame efficiently.
Yu Liu, T. Rohwerder, M. L. Bonatelli, Theda von Postel, S. Kleinsteuber, L. Adrian, Chang Ding   +6 more
semanticscholar   +1 more source

Identification and characterization of a glycosulfatase-encoding gene cluster in Bifidobacterium breve UCC2003 [PDF]

, 2016
Bifidobacteria constitute a specific group of commensal bacteria, typically found in the gastrointestinal tract (GIT) of humans and other mammals. Bifidobacterium breve strains are numerically prevalent among the gut microbiota of many healthy breast-fed
Egan, Muireann, Jiang, Hao, O'Connell Motherway, Mary, Oscarson, Stefan, van Sinderen, Douwe   +4 more
core   +1 more source

Impact of elosulfase alfa in patients with morquio A syndrome who have limited ambulation: An open-label, phase 2 study. [PDF]

, 2017
Efficacy and safety of elosulfase alfa enzyme replacement therapy (ERT) were assessed in an open-label, phase 2, multi-national study in Morquio A patients aged ≥5 years unable to walk ≥30 meters in the 6-min walk test.
Berger, Kenneth I, Burton, Barbara K, Decker, Celeste, Geberhiwot, Tarekegn, Harmatz, Paul R, Hendriksz, Christian J, Jameson, Elisabeth, Jester, Andrea, Mengel, Eugen, Muschol, Nicole, Sisic, Zlatko, Treadwell, Marsha   +11 more
core   +1 more source

Cloning and Characterization of a Novel N-Acetyl-D-galactosamine-4-O-sulfate Sulfatase, SulA1, from a Marine Arthrobacter Strain

Marine Drugs
Sulfation is gaining increased interest due to the role of sulfate in the bioactivity of many polysaccharides of marine origin. Hence, sulfatases, enzymes that control the degree of sulfation, are being more extensively researched.
Monica Daugbjerg Christensen, Leila Allahgholi, Javier A. Linares-Pastén, Ólafur Friðjónsson, Hörður Guðmundsson, Varsha Kale, Roya R. R. Sardari, Guðmundur Ó. Hreggviðsson, Eva Nordberg Karlsson   +8 more
doaj   +1 more source

Determination of desulpho-glucosinolates in bolting stems of Chinese kale by liquid chromatography-mass spectrometry

浙江大学学报. 农业与生命科学版, 2008
The crude glucosinolates (GSs) were extracted from bolting stems of Chinese kale (Brassica alboglabra) and purified by a column packed with DEAE Sephadex A-25. The desulpho-glucosinolates were obtained after desulfurizing of GSs by sulfatase.
LA Gui-xiao, FANG Ping, LI Ya-juan, WANG Yue   +3 more
doaj   +1 more source

Multiple sulfatase deficiency with neonatal manifestation. [PDF]

, 2014
Multiple Sulfatase Deficiency (MSD; OMIM 272200) is a rare autosomal recessive inborn error of metabolism caused by mutations in the sulfatase modifying factor 1 gene, encoding the formylglycine-generating enzyme (FGE), and resulting in tissue ...
Ballabio, A., Bernasconi, S., Braibanti, S., Frattini, D., Gabrielli, O., Galeazzi, T., Garavelli, L., Gargano, G., Gelmini, C., Iori, A., Iughetti, L., Ivanovski, I., Melli, N., Padella, L., Pedori, S., Pepe, S., Rosato, S., Santoro, L., Superti-Furga, A., Wischmeijer, A., Zampini, L.   +20 more
core   +1 more source

Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. [PDF]

PLoS ONE, 2013
The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate ...
Kimberly M Sogi, Zev J Gartner, Mark A Breidenbach, Mason J Appel, Michael W Schelle, Carolyn R Bertozzi   +5 more
doaj   +1 more source